re Vascular Parameters Associated with Walking Impairment in Patients with Claudication

Author(s)

da Silva, Gustavo Oliveira ^[1] ; Correia, Marilia de Almeida ^[1] ; Mesquita de Oliveira, Paulo Longano ^[1] ; Farah, Breno Quintella ^{[2, 3]} ; Vianna, Lauro C. ^[4] ; Puech-Leao, Pedro ^[5] ; Wolosker, Nelson ^[6] ; Cucato, Gabriel Grizzo ^[7] ; Ritti-Dias, Raphael Mendes ^[1]

Affiliation

^[1] Nave de Julho Univ, Sao Paulo, SP - Brazil

^[2] Rural Fed Univ Pernambuco, Phys Educ Dept, Recife, PE - Brazil

^[3] Fed Univ Pernambuco UFPE, Grad Program Phys Educ, Recife, PE - Brazil

^[4] Univ Brasilia, Fac Phys Educ, NeuroVASQ Integrat Physiol Lab, Brasilia, DF - Brazil

^[5] Univ Sao Paulo, Hosp Clin, Fac Med, Sao Paulo, SP - Brazil

^[6] Hosp Israelita Albert Einstein, Sao Paulo, SP - Brazil

^[7] Northumbria Univ, Newcastle Upon Tyne, Tyne & Wear - England

• Document type: Journal article
• Source: ANNALS OF VASCULAR SURGERY; v. 77, p. 31-37, NOV 2021.
• Web of Science Citations: 0

Abstract

Background: The mechanisms underlying functional impairments in symptomatic PAD patients are controversial and poorly understood. Endothelial dysfunction and arterial stiffness have been proposed as potential mechanisms related to functional impairment in symptomatic PAD patients, however, more studies are needed to confirm these associations. Objective: To analyze the association between vascular function and walking impairment in patients with peripheral arterial disease (PAD) and symptoms of claudication. Methods: This was a cross-sectional study that included 68 patients with symptomatic PAD. All patients underwent an objective (Six-minute walk test {[}6MWT], 4-meter walk test) and a subjective (Walking Impairment Questionnaire {[}WIQ]) measurement of walking impairment. Vascular parameters measured were pulse-wave velocity (PWV) and flow-mediated dilation (FMD). Multiple linear regression was performed to investigate the association among walking impairment variables with vascular function parameters. Results: No significant associations between the claudication onset distance (PWV: b=.060, P = 0.842; FMD: b=-.192, P = 0.456), 6MWT (PWV: b=.007, P = 0..975; FMD: b=.090, P = 0.725), WIQ distance (PWV: b=.337, P = 0.117; FMD: b=-.025, P = 0.895) WIQ speed (PWV: b=.320, P = 0.181; FMD: b=-.028, P = 0.497), WIQ stairs (PWV: b=.256, P = 0.204; FMD: b=.228, P = 0.230), 4-meter usual walk (PWV: b=-.421, P = 0.107; FMD: b= -.338, P = 0.112), 4-meter fast walk (PWV: b=-.496, P = 0.063; FMD: b=-.371, P = 0.086) and vascular function were found. Conclusions: In symptomatic PAD patients, vascular function is not associated to walking impairment, even when adjusting for comorbid conditions and diabetes. (AU)

• FAPESP's process: 19/05221-1 - Acute effects of breaks in sedentary behaviorwith isometric exercise on adult cardiovascular health indicators
• Grantee: Gustavo Oliveira da Silva
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 16/16425-9 - Effects of handgrip isometric training on blood pressure, endothelial function and cardiac autonomic modulation in patients with peripheral artery disease: a randomized controlled study.
• Grantee: Raphael Mendes Ritti Dias
• Support Opportunities: Regular Research Grants