Comparison between connective tissue graft and xenogeneic acellular dermal matrix to treat single gingival recession: A data reanalysis of randomized clinical trials

Author(s)

Viana Miguel, Manuela Maria ; Ferreira Ferraz, Lais Fernanda ; Rossato, Amanda ; Faria Cintra, Tuana Mendonca ; Mathias-Santamaria, Ingrid Fernandes ; Santamaria, Mauro Pedrine

• Document type: Journal article
• Source: Journal of Esthetic and Restorative Dentistry; v. N/A, p. 10-pg., 2022-06-07.

Abstract

Objectives There are few studies comparing xenogeneic acellular dermal matrixes (XDMs) with connective tissue graft (CTG) to treat single gingival recession (GR). The present study involved a reanalysis of previous studies and comparison of CTG or XDM to treat single RT1/GR. Materials and methods Fifty patients from three previous randomized clinical trials treated either by CTG (n = 25) or XDM (n = 25) were evaluated after 6-month. Clinical, patient-centered, and esthetic parameters were assessed. Pearson's correlation and regression analyses were also performed. Results Greater recession reduction (RecRed), percentage of root coverage (%RC), and complete root coverage (CRC) were observed in the CTG group (p <= 0.02). Gingival thickness (GT) and keratinized tissue width (KTW) gains were higher in the CTG group. The CTG group showed better esthetic at 6-month. Logistic analyses reported that GT([OR] = 1.647(3)) and papilla height (PH) (OR = 8.20) are predictors of CRC. GT*XDM interaction was a negative predictor of CRC (OR = 7.105(-5)). GT at baseline acted as a predictor of RecRed in both groups (p = 0.03). The XDM graft impacted RecRed and %RC negatively. Baseline PH was a predictor of %RC for both grafts. Conclusion CTG was superior for treating RT1/GR, providing better root coverage outcomes and tissue gains over time. GT, PH, and graft type were classified as predictors of CRC. Clinical significance CTG presented better outcomes to treat single RT1 gingival recession when compared to the XDM. (AU)

• FAPESP's process: 21/00588-4 - Comparison between the use of connective tissue graft and porcine acellular dermal matrix associated with coronally advanced flap to treat single gingival recessions: reanalysis of data from two randomized clinical studies
• Grantee: Tuana Mendonça Faria Cintra
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 12/14595-3 - The influence of low intensity laser therapy (LILT) in connective tissue graft for root coverage: a randomized-controlled clinical trial
• Grantee: Mauro Pedrine Santamaria
• Support Opportunities: Regular Research Grants
• FAPESP's process: 14/00119-0 - Evaluation of two different types of flap associated with connective tissue graft in the treatment of gingival recession: randomized clinical trial
• Grantee: Felipe Lucas da Silva Neves
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 18/03284-3 - Comparison between porcine acellular dermal matrix (Mucoderm®) versus connective tissue graft in the treatment of multiple gingival recessions associated with non-carious cervical lesion partially restored: randomized clinical trial
• Grantee: Amanda Rossato
• Support Opportunities: Scholarships in Brazil - Master