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Comparison between the use of connective tissue graft and porcine acellular dermal matrix associated with coronally advanced flap to treat single gingival recessions: reanalysis of data from two randomized clinical studies

Grant number: 21/00588-4
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): June 01, 2021
Effective date (End): February 28, 2023
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal Investigator:Mauro Pedrine Santamaria
Grantee:Tuana Mendonça Faria Cintra
Host Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Estadual Paulista (UNESP). Campus de São José dos Campos. São José dos Campos , SP, Brazil


Gingival recession (GR) is a prevalent issue correlated to aesthetic demands and dentin hypersensitivity (DH). The association between coronally advanced flap (CAF) and the subepithelial connective tissue graft (CTG) is considered the gold standard to treat a single GR. This technique promotes higher root coverage predictably, as well as long-term stability. However, the autogenous graft is directly associated with morbidity and patient discomfort after the surgical procedure. Therefore, biomaterials have been developed with the aim to substitute CTG, as, for example, a xenogeneic acellular dermal matrix (XDM). This tridimensional matrix presents features that favor its use in mucogingival surgeries due to CTG similar behavior. Despite the Literature demonstrating XDM use in peri-implant mucosa and multiple gingival recession, low evidence in the long term is present toward XDM use in single defects. Moreover, previous clinical characteristics and surgery undergoes may directly influence root coverage procedures outcomes. The study of independent clinical predictors can forward the patient to therapy that will provide a better prognosis. Thus, the aim of the present study is to compare the use of the XDM versus CTG by the CAF technique for the treatment of single gingival recessions RT1. In addition, evaluate independent clinical predictors which may directly affect root coverage procedure outcomes. For this, 25 single gingival recession per group (50 single gingival recession in total) will be evaluated in the baseline, 6 months, 1 year, and 2 years, by clinical parameters, as recession reduction, complete root coverage, root coverage percent, tissue keratin gain and, tissue thickness; patient-centered parameters and aesthetics. In addition, will be verified predictors clinical variables for root coverage success by logistic and linear regression, as well as possible associations among the cited parameters by correlation analysis. (AU)

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