| Full text | |
| Author(s): |
Rebello, Keila
;
Moura, Luciana Monteiro
;
Arantes Bueno, Ana Paula
;
Picon, Felipe Almeida
;
Pan, Pedro Mario
;
Gadelha, Ary
;
Miguel, Euripedes Constatino
;
Bressan, Rodrigo Affonseca
;
Rohde, Luis Augusto
;
Sato, Joao Ricardo
Total Authors: 10
|
| Document type: | Journal article |
| Source: | INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH; v. 19, n. 10, p. 10-pg., 2022-05-01. |
| Abstract | |
Background: Most early children's experiences will occur in a family context; therefore, the quality of this environment is critical for development outcomes. Not many studies have assessed the correlations between brain functional connectivity (FC) in important areas such as the default mode network (DMN) and the quality of parent-child relationships in school-age children and early adolescence. The quality of family relationships and maternal behavior have been suggested to modulate DMN FC once they act as external regulators of children's affect and behavior. Objective: We aimed to test the associations between the quality of family environment/maternal behavior and FC within the DMN of school-age children. Method: Resting-state, functional magnetic resonance imaging data, were collected from 615 children (6-12 age range) enrolled in the Brazilian High-Risk Cohort (HRC) study. We assessed DMN intra-connectivity between the medial prefrontal cortex (mPFC), posterior cingulate cortex (PCC), and inferior parietal lobule (IPL-bilateral) regions. The family functioning was assessed by levels of family cohesiveness and conflict and by maternal behavior styles such as maternal responsiveness, maternal stimulus to the child's autonomy, and maternal overprotection. The family environment was assessed with the Family Environment Scale (FES), and maternal behavior was assessed by the mother's self-report. Results: We found that the quality of the family environment was correlated with intra-DMN FC. The more conflicting the family environment was, the greater the FC between the mPFC-left IPL (lIPL), while a more cohesive family functioning was negatively correlated with FC between the PCC-lIPL. On the other hand, when moderated by a positive maternal behavior, cohesive family functioning was associated with increased FC in both regions of the DMN (mPFC-lIPL and PCC-lIPL). Conclusions: Our results highlight that the quality of the family environment might be associated with differences in the intrinsic DMN FC. (AU) | |
| FAPESP's process: | 21/05332-8 - Brazilian high-risk cohort for psychiatric disorders: 10 years follow-up |
| Grantee: | Rodrigo Affonseca Bressan |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 18/04654-9 - Time series, wavelets and high dimensional data |
| Grantee: | Pedro Alberto Morettin |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 14/50917-0 - INCT 2014: developmental psychiatry for children and adolescents |
| Grantee: | Eurípedes Constantino Miguel Filho |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 16/19376-9 - Structural and functional Papez circuit integrity and its relations to symptomology in Amyotrophic Lateral Sclerosis |
| Grantee: | Ana Paula Arantes de Andrade Bueno |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 18/21934-5 - Network statistics: theory, methods, and applications |
| Grantee: | André Fujita |
| Support Opportunities: | Research Projects - Thematic Grants |