| Full text | |
| Author(s): |
de Souza, Izadora
;
Clares Ramalho, Maria Carolina
;
Guedes, Camila Banca
;
Araujo Osawa, Isabeli Yumi
;
Seregni Monteiro, Linda Karolynne
;
Gomes, Luciana Rodrigues
;
Reily Rocha, Clarissa Ribeiro
Total Authors: 7
|
| Document type: | Journal article |
| Source: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 23, n. 13, p. 21-pg., 2022-07-01. |
| Abstract | |
Glioblastoma multiforme is a lethal disease and represents the most common and severe type of glioma. Drug resistance and the evasion of cell death are the main characteristics of its malignancy, leading to a high percentage of disease recurrence and the patients' low survival rate. Exploiting the modulation of cell death mechanisms could be an important strategy to prevent tumor development and reverse the high mortality and morbidity rates in glioblastoma patients. Ferroptosis is a recently described type of cell death, which is characterized by iron accumulation, high levels of polyunsaturated fatty acid (PUFA)-containing phospholipids, and deficiency in lipid peroxidation repair. Several studies have demonstrated that ferroptosis has a potential role in cancer treatment and could be a promising approach for glioblastoma patients. Thus, here, we present an overview of the mechanisms of the iron-dependent cell death and summarize the current findings of ferroptosis modulation on glioblastoma including its non-canonical pathway. Moreover, we focused on new ferroptosis-inducing compounds for glioma treatment, and we highlight the key ferroptosis-related genes to glioma prognosis, which could be further explored. Thereby, understanding how to trigger ferroptosis in glioblastoma may provide promising pharmacological targets and indicate new therapeutic approaches to increase the survival of glioblastoma patients. (AU) | |
| FAPESP's process: | 19/27080-0 - Role of chaperone-mediated autophagy in breast cancer |
| Grantee: | Luciana Rodrigues Gomes |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 19/15320-7 - Construction of fluorescently-labeled cell lines to evaluate cancer-associated processes in live cells |
| Grantee: | Nadja Cristhina de Souza Pinto |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 19/19435-3 - The role of DNA damage and mitochondrial function in vascular, immune and neurological ageing (DNA MoVINg) |
| Grantee: | Carlos Frederico Martins Menck |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 13/07467-1 - CeTICS - Center of Toxins, Immune-Response and Cell Signaling |
| Grantee: | Hugo Aguirre Armelin |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |
| FAPESP's process: | 19/26268-6 - Exploring the role of ferroptosis in temozolomide death induction in glioblastoma |
| Grantee: | Izadora de Souza |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 19/21745-0 - Exploring drug resistance mechanisms in cancer cells via CRISPR libraries |
| Grantee: | Clarissa Ribeiro Reily Rocha |
| Support Opportunities: | Regular Research Grants |