Antioxidant, antimicrobial and healing properties of an extract from coffee pulp for the development of a phytocosmetic

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dos Santos, erica Mendes ; de Macedo, Lucas Malvezzi ; Ataide, Janaina Artem ; Delafiori, Jeany ; Guarnieri, Joao Paulo de Oliveira ; Rosa, Paulo Cesar Pires ; Ruiz, Ana Lucia Tasca Gois ; Lancellotti, Marcelo ; Jozala, Angela Faustino ; Catharino, Rodrigo Ramos ; Camargo, Gisele Anne ; Paiva-Santos, Ana Claudia ; Mazzola, Priscila Gava

• Document type: Journal article
• Source: SCIENTIFIC REPORTS; v. 14, n. 1, p. 11-pg., 2024-02-23.

Abstract

Consumer demand for natural, chemical-free products has grown. Food industry residues, like coffee pulp, rich in caffeine, chlorogenic acid and phenolic compounds, offer potential for pharmaceutical and cosmetic applications due to their antioxidant, anti-inflammatory, and antibacterial properties. Therefore, the objective of this work was to develop a phytocosmetic only with natural products containing coffee pulp extract as active pharmaceutical ingredient with antioxidant, antimicrobial and healing activity. Eight samples from Coffea arabica and Coffea canephora Pierre were analyzed for caffeine, chlorogenic acid, phenolic compounds, tannins, flavonoids, cytotoxicity, antibacterial activity, and healing potential. The Robusta IAC-extract had the greatest prominence with 192.92 mu g/mL of chlorogenic acid, 58.98 +/- 2.88 mg GAE/g sample in the FRAP test, 79.53 +/- 5.61 mg GAE/g sample in the test of total phenolics, was not cytotoxic, and MIC 3 mg/mL against Staphylococcus aureus. This extract was incorporated into a stable formulation and preferred by 88% of volunteers. At last, a scratch assay exhibited the formulation promoted cell migration after 24 h, therefore, increased scratch retraction. In this way, it was possible to develop a phytocosmetic with the coffee pulp that showed desirable antioxidant, antimicrobial and healing properties. (AU)

• FAPESP's process: 20/11333-4 - Development of a polysaccharide membrane containing extract from the shell of Spondias mombin L. for the treatment of Pressure Ulcers
• Grantee: Érica Mendes dos Santos
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 18/06475-4 - Development of pharmaceutical formulation for burns' healing
• Grantee: Janaína Artem Ataide
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 22/06228-2 - Development of polysaccharide membrane containing plant extract for pressure Ulcer treatment
• Grantee: Priscila Gava Mazzola
• Support Opportunities: Regular Research Grants
• FAPESP's process: 14/50938-8 - INCT 2014: in Photonics Applied to Cell Biology
• Grantee: Hernandes Faustino de Carvalho
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 19/05718-3 - Determination of metabolic alterations and therapeutic potential of Zika Virus in cancer cells by mass spectrometry and artificial intelligence
• Grantee: Jeany Delafiori
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)