Ability of Hypocaloric Diets to Change Nutrient-Phyla Associations after 8 Weeks of Intervention

Author(s)

Noronha, Natalia Yumi ; Martins, Luzania dos Santos ; Watanabe, Ligia Moriguchi ; Pinhel, Marcela Augusta de Souza ; Rodrigues, Guilherme da Silva ; Schneider, Isabelle Mello ; Nicoletti, Carolina Ferreira ; Delfino, Heitor Bernardes Pereira ; Carlos, Daniela ; Nonino, Carla Barbosa

• Document type: Journal article
• Source: OBESITIES; v. 4, n. 2, p. 10-pg., 2024-06-01.

Abstract

Background: Previous studies have suggested that changes in the composition of intestinal microbiota may be influenced by dietary quality. Objective: This study aimed to assess the impact of a hypocaloric diet on the relationship between microbiota and clinical/dietary variables. Methods: This was a longitudinal study. Ten women with obesity (Obese Group, ObG) participated in an 8-week home-based hypocaloric diet intervention. Anthropometric, dietary intake, biochemical, and gut microbiota assessments were conducted before and after the intervention. Microbiota relative abundance was determined using real-time PCR in triplicate. Results: In the ObG, the hypocaloric diet intervention led to significant weight loss (before: 119.5 +/- 10.3 kg; after: 114.9 +/- 10.2 kg; p = 0.003). Following the intervention, positive correlations were observed between nutrient intake and phyla composition: Actinobacteria phylum with fibers (r = 0.787; p = 0.012), Firmicutes phylum with proteins (r = 0.736; p = 0.024), and Proteobacteria phylum with lipids (r = 0.669; p = 0.049). Conclusions: The hypocaloric diet intervention improved health parameters associated with obesity and its comorbidities, demonstrating associations between nutrient intake and specific phyla. (AU)

• FAPESP's process: 12/10395-0 - Role of NLRs receptors in immunoregulation mechanisms of the type 1 and 2 diabetes: identification of potential therapeutic targets
• Grantee: Daniela Carlos Sartori
• Support Opportunities: Research Grants - Young Investigators Grants
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• FAPESP's process: 18/24069-3 - ReSEARCH: Recognizing Signatures of the Exposome to Anticipate the Risks for a Continuous Health
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• FAPESP's process: 20/08687-9 - Selenium deficiency: identification of a risk profile considering genetic, clinical and environmental factors of patients with obesity in the pre and postoperative period of bariatric surgery
• Grantee: Lígia Moriguchi Watanabe
• Support Opportunities: Scholarships in Brazil - Post-Doctoral