In vitro gastrointestinal digestion and gut microbiota fermentation of phenolic compounds from uvaia

Author(s)

Farias, David de Paulo ; Araujo, Fabio Fernandes de ; Villasante, Juliana ; Fogliano, Vincenzo ; Pastore, Glaucia Maria

• Document type: Journal article
• Source: Food Chemistry; v. 477, p. 10-pg., 2025-03-04.

Abstract

Gastrointestinal digestion and gut microbiota fermentation can alter the bioaccessibility and bioactivity of phenolic compounds. This study assessed the effects of gastrointestinal digestion and gut microbiota fermentation on the bioaccessibility, bioactivity, and catabolism of phenolic compounds from uvaia (Eugenia pyriformis) seed and edible fraction (pulp + peel). The bioaccessibility of epigallocatechin, epicatechin, myricetin, and ferulic acid increased after the gastrointestinal digestion of the edible fraction, while seed digestion reduced epigallocatechin, procyanidin B2, and salicyl aldehyde levels. Acetate and butyrate production was higher from uvaia seed after 24-h fermentation (212.93 and 192.09 mg/L, respectively), while propionate production was higher from the edible fraction (63.37 mg/L). These findings suggest that gastrointestinal digestion influences the bioaccessibility and bioactivity of phenolic compounds in uvaia fractions. Additionally, the increased production of short-chain fatty acids points to a potential prebiotic effect, highlighting the potential of uvaia for developing intestinal health-promoting food products or supplements. (AU)

• FAPESP's process: 22/04530-3 - Antidiabetic potential of xique-xique (Pilosocereus gounellei) and mandacaru (Cereus jamacaru) fruits after colonic fermentation
• Grantee: Fábio Fernandes de Araújo
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• FAPESP's process: 22/05242-1 - Effect of colonic fermentation on the antidiabetic potential of uvaia (Eugenia pyriformis Cambess.)
• Grantee: David de Paulo Farias
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• FAPESP's process: 15/50333-1 - COBRA: a novel compound discovery pipeline for rapid and cost-effective identification of bioactives with health beneficial effects in Brazilian crops
• Grantee: Glaucia Maria Pastore
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 20/15163-6 - Determination of chemical composition, bioaccessibility and evaluation of antidiabetic and prebiotic activities from Xique-Xique (Pilosocereus gounellei) and Mandacaru (Cereus jamacaru) fruits
• Grantee: Fábio Fernandes de Araújo
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 20/00225-6 - Determination of antioxidant potential, in vitro bioaccessibility and evaluation of antidiabetic and prebiotic activities from the uvaia (Eugenia pyriformis Cambess)
• Grantee: David de Paulo Farias
• Support Opportunities: Scholarships in Brazil - Doctorate