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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Changes in bone mass, biomechanical properties, and microarchitecture of calcium- and iron-deficient rats fed diets supplemented with inulin-type fructans

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Author(s):
Lobo, Alexandre R. [1] ; Cocato, Maria Lucia [1] ; Jorgetti, Vanda [2] ; de Sa, Lilian R. M. [3] ; Nakano, Eduardo Y. [4] ; Colli, Celia [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Food & Expt Nutr, BR-05508900 Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Nephrol, Sch Med, BR-05508900 Sao Paulo - Brazil
[3] Univ Sao Paulo, Dept Pathol, Sch Vet Med, BR-05508900 Sao Paulo - Brazil
[4] Univ Brasilia, Dept Stat, BR-70910900 Brasilia, DF - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Nutrition Research; v. 29, n. 12, p. 873-881, DEC 2009.
Web of Science Citations: 13
Abstract

Feeding mineral-deficient diets enhances absorptive efficiency as an attempt of the body to compensate for the lack of an essential nutrient. Under certain circumstances, it does not succeed, and nutritional deficiency is produced Our hypothesis was that mulin-type fructans (ITF), which arc known to affect mineral absorption, could increase Ca and Fe bioavailability in Ca- and Fe-deficient rats. Male Wistar rats (n = 48, 4 weeks old) were assigned to I of 8 groups derived from 2 x 2 x 2 factorial design with 2 levels of added Fe (0 and 35 mg/kg), Ca (0 and 5 g/kg), and ITF (0 and 100 g/kg) for 33 days. The Fe status (hemoglobin, serum Fe, total Fe-binding capacity, transferrin saturation, liver minerals) was evaluated. Tibia minerals (Ca, Mg, and Zn), bone strength, and histomorphometry were determined In nondeficient rats, ITF supplementation did not affect Fe status or organ minerals, with the exception of tibia Mg Moreover, ITF improved bone resilience and led to a reduction in eroded surface per body surface and number of osteoclasts per area In Ca-deficient rats, ITF increased liver (Fe and Zn) and tibia (Zn) mineral levels but impaired tibia Mg, yield load, and resilience. In conclusion, ITF worsened the tibia Mg levels and elastic properties when supplemented in Ca-deficient diets In contrast, although bone Ca was not affected in nondeficient rats under the present experimental conditions, bone quality improved, as demonstrated by a moderate reduction in femur osteoclast resorption and significant increases in tibia Mg content and elasticity. (C) 2009 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 06/01735-0 - Physiological consequences of different ingestion levels of iron and calcium and their interaction with phytates and fructans: study in rats
Grantee:Célia Colli
Support Opportunities: Regular Research Grants