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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Molecular Genotyping and Epidemiology of Mycobacterium tuberculosis Isolates Obtained from Inmates of Correctional Institutions of Campinas, Southeast Brazil

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Author(s):
Moreira-Oliveira, M. S. [1] ; Oliveira, H. B. [2] ; Pace, F. [1] ; Stehling, E. G. [1] ; Rocha, M. M. M. [3] ; Aily, D. C. G. [3] ; Brocchi, M. [1] ; Silveira, W. D. [1]
Total Authors: 8
Affiliation:
[1] Univ Estadual Campinas, Inst Biol, Dept Microbiol & Immunol, BR-13081862 Campinas, SP - Brazil
[2] Univ Estadual Campinas, Sch Med Sci, Dept Prevent & Social Med, BR-13081862 Campinas, SP - Brazil
[3] Adolfo Lutz Inst Campinas, Div Med Biol, Campinas, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Brazilian Journal of Infectious Diseases; v. 12, n. 6, p. 487-493, DEC 2008.
Web of Science Citations: 8
Abstract

The objective of this study was to investigate the possible transmission of tuberculosis among 39 inmates with positive Mycobacterium tuberculosis smears in four correctional institutions located in Campinas City, SP, Brazil over a 19-month period. Fifty-one M. tuberculosis isolates from these inmates were characterized according to the number of IS6110 insertion elements present in their genomic DNA. The number of insertion elements in M. tuberculosis isolates varied from two to twelve. The dendrogram of similarity resulted in the grouping the isolates in six main clusters. These results, associated to epidemiological data, suggested the transmission of tuberculosis among inmates of the same and different institutions inmates. Univariate analysis of epidemiological data (total delay for beginning of treatment, previous treatment, and HIV status) and clustering occurrence showed that only ``previous treatment{''} (OR = 7.65, p = 0.032) was associated with the possible transmission of tuberculosis in the studied prisons. (AU)