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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cell viability and adhesion on diamond-like carbon films containing titanium dioxide nanoparticles

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Author(s):
Wachesk, C. C. [1] ; Pires, C. A. F. [1] ; Ramos, B. C. [2] ; Trava-Airoldi, V. J. [3] ; Lobo, A. O. [2] ; Pacheco-Soares, C. [1] ; Marciano, F. R. [2] ; Da-Silva, N. S. [1]
Total Authors: 8
Affiliation:
[1] Univ Vale Paraiba Univap, Lab Biomed Nanotechnol NanoBio, Lab Biol Celular & Tecidual, BR-12244000 Sao Jose Dos Campos, SP - Brazil
[2] Univ Vale Paraiba Univap, Lab Biomed Nanotechnol NanoBio, BR-12244000 Sao Jose Dos Campos, SP - Brazil
[3] INPE, Associated Lab Sensors & Mat, BR-12227010 Sao Jose Dos Campos, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Applied Surface Science; v. 266, p. 176-181, FEB 1 2013.
Web of Science Citations: 19
Abstract

The combination of low friction, wear resistance, high hardness, biocompatibility and chemical inertness makes diamond-like carbon (DLC) films suitable in a numerous applications in biomedical engineering. The cell viability and adhesion of L929 mouse fibroblasts was investigated using two different colorimetric assays: (i) 2-(4,5-dimethyl-2-thiazolyl)-3,5-diphenyl-2H-tetrazolium bromide (MTT), and (ii) lactate dehydrogenase (LDH). The films were growth on 316L stainless steel substrates using plasma enhanced chemical vapor deposition technique from a dispersion of TiO2 nanopowder in hexane. The increasing concentration of TiO2 nanoparticles in DLC films enhanced the mitochondrial activity and decreases the LDH activity on these samples. Fluorescence and scanning electron microscopy corroborate the results. These experiments show the potential use of DLC and TiO2-DLC films in biomedical applications. (c) 2012 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 11/20345-7 - Study of nanoparticle-incorporated diamond-like carbon films for biomedical applications
Grantee:Fernanda Roberta Marciano
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 11/17877-7 - Development of new polymeric scaffolds by electrospinning technique with incorporation of vertically aligned carbon nanotubes and nanohidroxyapatite for bone tissue regeneration
Grantee:Anderson de Oliveira Lobo
Support Opportunities: Research Grants - Young Investigators Grants