Myositis-specific and myositis-associated autoantibody profiles and their clinical associations in a large series of patients with polymyositis and dermatomyositis

Author(s)

Marcela Gran Pina Cruellas ^[1] ; Vilma dos Santos Trindade Viana ^[1] ; Maurício Levy-Neto ^[3] ; Fernando Henrique Carlos de Souza ^[1] ; Samuel Katsuyuki Shinjo ^[1]

Affiliation

^[1] Univ Sao Paulo, Fac Med, Disciplina Reumatol, Sao Paulo - Brazil

^[2] Universidade de São Paulo. Faculdade de Medicina - Brasil

• Document type: Journal article
• Source: Clinics; v. 68, n. 7, p. 909-914, 2013-07-00.

Abstract

OBJECTIVE: To analyze the prevalence of myositis-specific and myositis-associated autoantibodies and their clinical correlations in a large series of patients with dermatomyositis/polymyositis. METHOD: This cross-sectional study enrolled 127 dermatomyositis cases and 95 polymyositis cases. The disease-related autoantibody profiles were determined using a commercially available blood testing kit. RESULTS: The prevalence of myositis-specific autoantibodies in all 222 patients was 34.4%, whereas myositis-associated autoantibodies were found in 41.4% of the patients. The most frequently found autoantibody was anti-Ro-52 (36.9%), followed by anti-Jo-1 (18.9%), anti-Mi-2 (8.1%), anti-Ku (4.1%), anti-SRP (3.2%), anti-PL-7 (3.2%), anti-PL-12 (2.7%), anti-PM/Scl75 (2.7%), and anti-PM/Scl100 (2.7%). The distributions of these autoantibodies were comparable between polymyositis and dermatomyositis, except for a higher prevalence of anti-Jo-1 in polymyositis. Anti-Mi-2 was more prevalent in dermatomyositis. Notably, in the multivariate analysis, anti-Mi-2 and anti-Ro-52 were associated with photosensitivity and pulmonary disorders, respectively, in dermatomyositis. Anti-Jo-1 was significantly correlated with pulmonary disorders in polymyositis. Moreover, anti-Ro-52 was associated with anti-Jo-1 in both diseases. No significant correlation was observed between the remaining autoantibodies and the clinical and/or laboratory findings. CONCLUSIONS: Our data are consistent with those from other published studies involving other populations, although certain findings warrant consideration. Anti-Ro-52 and anti-Jo-1 were strongly associated with one another. Anti-Ro-52 was correlated with pulmonary disorders in dermatomyositis, whereas anti-Jo-1 was correlated with pulmonary alterations in polymyositis. (AU)

• FAPESP's process: 11/12700-1 - Profile and prevalence of myositis-specific and myositis-associated autoantibodies in Brazilian population with dermatomyositis/polymyositis
• Grantee: Samuel Katsuyuki Shinjo
• Support Opportunities: Regular Research Grants