Estudo do envolvimento do sistema opióide, serotoninérgico e noradrenérgico do sistema endógeno de inibição de dor em processos antinociceptivos induzidos por reações de fuga orientada evocada pela estimulação química do hipotálamo medial

• Processo: 07/01174-1
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Data de Início da vigência: 01 de março de 2008
• Data de Término da vigência: 28 de fevereiro de 2010
• Área do conhecimento: Ciências Biológicas - Morfologia - Anatomia
• Pesquisador responsável: Norberto Cysne Coimbra
• Beneficiário: Norberto Cysne Coimbra
• Instituição Sede: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brasil
• Assunto(s): Hipotálamo Diencéfalo
• Palavra(s)-Chave do Pesquisador: Diencéfalo | Hipotálamo | Sistema noradrenérgico | Sistema opióide | sistema serotonérgico | Neuroanatomia Funcional

Resumo

A estimulação elétrica e química de algumas estruturas mesencefálicas, tais como a substância cinzenta periaquedutal dorsal (SCPd), as camadas profundas do colículo superior (CPCS) e o núcleo central do colículo inferior (NCCI) eliciam respostas defensivas explosivas, associadas ao medo e semelhantes àquelas que caracterizam a síndrome do pânico em humanos. Contudo, quando a estimulação é realizada em núcleos do hipotálamo medial, a resposta defensiva caracteriza-se por uma reação de fuga de intensidade moderada com saltos orientados, rica em comportamento exploratório. Não obstante, há uma grande escassez de trabalhos sobre as bases neuroanatômicas e neurofarmacológicas do comportamento de fuga orientada organizado no hipotálamo medial. Há evidências mostrando que alguns processos antinociceptivos são elaborados durante a evocação de respostas motoras defensivas após a estimulação do teto mesencefálico, como também tem sido descrito o envolvimento de núcleos hipotalâmicos laterais e arqueado em processos antinociceptivos de natureza opióide e não-opióide, muito embora não esteja claro o envolvimento do sistema endógeno de inibição de dor nesses processos antinociceptivos.O objetivo deste trabalho consiste em determinar uma possível interface funcional entre o hipotálamo medial e núcleos ricos em peptídeos opióides endógenos, serotonina ou noradrenalina do sistema endógeno de inibição de dor proposto por Basbaum e Fields, em 1984. Essa interface funcional será estudada por meio da ativação de neurônios do hipotálamo dorso-medial (HDM) e ventro-medial (HVM), seguida da imunolocalização da proteína Fos em núcleos do tronco encefálico envolvidos com o processo de inibição de dor e com atividades límbicas. A ativação hipotalâmica será feita por meio de microinjeções unilaterais de bicuculina (antagonista de receptores GABAA) no núcleos HVM e HDM. Essa reação antígeno-anticorpo será revelada com DAB e superposta a uma outra reação antígeno-anticorpo (revelada com VIPDAB), com o objetivo de identificar a presença de leu-encefalina, -endorfina, serotonina ou tirosina hidroxilase nos substratos neurais que expressam a proteína Fos após a evocação de respostas comportamentais induzidas pelo bloqueio de receptores GABAA no HDM e no HVM, em grupos independentes de animais.Serão também determinados os efeitos do pré-tratamento com microinjeções de antagonistas opióides em núcleos ricos em encefalina e -endorfina que possuem conexões diretas com os núcleos HVM e HDM, como a SCP, ao passo que microinjeções de antagonistas serotoninérgicos serão realizadas no NDR, e antagonistas noradrenérgicos serão microinjetados no LC para avaliarmos o envolvimento dessas redes neurais implicadas no controle da dor durante a organização da antinocicepção induzida por reações de defesa orientada. (AU)

Publicações científicas

(40)

(Referências obtidas automaticamente do Web of Science e do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores)

DOS ANJOS-GARCIA, TAYLLON; ULLAH, FARHAD; FALCONI-SOBRINHO, LUIZ LUCIANO; COIMBRA, NORBERTO CYSNE. CB1 cannabinoid receptor-mediated anandamide signalling reduces the defensive behaviour evoked through GABA(A) receptor blockade in the dorsomedial division of the ventromedial hypothalamus. Neuropharmacology, v. 113, n. A, p. 156-166, FEB 2017. (09/54014-7, 02/01497-1, 12/03798-0, 07/01174-1, 13/10984-8)

TEIXEIRA GONCALVES, THAIS CRISTINA; LONDE, ANNA KARLA; PIRES ALBANO, RAFAEL ISAAC; DE ARAUJO JUNIOR, ARTUR TEIXEIRA; AZEREDO, MARIANA DE AGUIAR; BIAGIONI, AUDREY FRANCISCO; FERREIRA VASCONCELLOS, THIAGO HENRIQUE; DOS REIS FERREIRA, CELIO MARCOS; TEIXEIRA, DULCINEA GONCALVES; DE SOUZA CRIPPA, JOSE ALEXANDRE; et al. Cannabidiol and endogenous opioid peptide-mediated mechanisms modulate antinociception induced by transcutaneous electrostimulation of the peripheral nervous system. JOURNAL OF THE NEUROLOGICAL SCIENCES, v. 347, n. 1-2, p. 82-89, DEC 15 2014. (07/01174-1, 08/08955-1, 02/01497-1, 12/03798-0)

CALVO, FABRICIO; LOBAO-SOARES, BRUNO; DE FREITAS, RENATO LEONARDO; PASCHOALIN-MAURIN, TATIANA; DOS ANJOS-GARCIA, TAYLLON; MEDEIROS, PRISCILA; DA SILVA, JULIANA ALMEIDA; LOVICK, THELMA ANDERSON; COIMBRA, NORBERTO CYSNE. The endogenous opioid system modulates defensive behavior evoked by Crotalus durissus terrificus: Panicolytic-like effect of intracollicular non-selective opioid receptors blockade. JOURNAL OF PSYCHOPHARMACOLOGY, v. 33, n. 1, p. 51-61, JAN 2019. (14/11869-0, 07/01174-1, 03/07202-6, 15/10313-1, 17/11855-8, 09/02458-9, 02/13307-2, 12/03798-0, 13/12916-0, 12/25167-2, 04/10173-0)

DA SILVA, JULIANA ALMEIDA; BIAGIONI, AUDREY FRANCESCHI; ALMADA, RAFAEL CARVALHO; DE FREITAS, RENATO LEONARDO; COIMBRA, NORBERTO CYSNE. Panicolytic-like effects caused by substantia nigra pars reticulata pretreatment with low doses of endomorphin-1 and high doses of CTOP or the NOP receptors antagonist JTC-801 in male Rattus norvegicus. Psychopharmacology, v. 234, n. 20, p. 3009-3025, OCT 2017. (14/11869-0, 09/02458-9, 03/05256-1, 14/10742-7, 01/03752-6, 17/11855-8, 12/03798-0, 09/54014-7, 10/15140-4, 02/01497-1, 13/12916-0, 09/17258-5, 07/01174-1, 15/10313-1, 12/22681-7)

DE OLIVEIRA, RICARDO; DE OLIVEIRA, RITHIELE CRISTINA; FALCONI-SOBRINHO, LUIZ LUCIANO; SOARES, JR., RAIMUNDO DA SILVA; COIMBRA, NORBERTO CYSNE. 5-Hydroxytryptamine(2A/2C) receptors of nucleus raphe magnus and gigantocellularis/paragigantocellularis pars alpha reticular nuclei modulate the unconditioned fear-induced antinociception evoked by electrical stimulation of deep layers of the superior colliculus and dorsal periaqueductal grey matter. Behavioural Brain Research, v. 316, p. 294-304, JAN 1 2017. (11/09850-1, 02/01497-1, 12/03798-0, 07/01174-1, 13/10984-8)

TWARDOWSCHY, ANDRE; COIMBRA, NORBERTO CYSNE. mu- and kappa-Opioid receptor activation in the dorsal periaqueductal grey matter differentially modulates panic-like behaviours induced by electrical and chemical stimulation of the inferior colliculus. Brain Research, v. 1597, p. 168-179, FEB 9 2015. (07/01174-1, 08/00531-8, 09/54014-7, 02/01497-1)

DA SILVA, JULIANA ALMEIDA; BIAGIONI, AUDREY FRANCISCO; ALMADA, RAFAEL CARVALHO; DE SOUZA CRIPPA, JOSE ALEXANDRE; CECILIO HALLAK, JAIME EDUARDO; ZUARDI, ANTONIO WALDO; COIMBRA, NORBERTO CYSNE. Dissociation between the panicolytic effect of cannabidiol microinjected into the substantia nigra, pars reticulata, and fear-induced antinociception elicited by bicuculline administration in deep layers of the superior colliculus: The role of CB1-cannabinoid receptor in the ventral mesencephalon. European Journal of Pharmacology, v. 758, p. 153-163, JUL 5 2015. (09/02458-9, 14/10742-7, 09/54014-7, 10/15140-4, 02/01497-1, 12/03798-0, 07/01174-1, 12/22681-7)

SOUZA DA SILVA, LUIS FELIPE; COIMBRA, NORBERTO CYSNE; MENESCAL-DE-OLIVEIRA, LEDA. Rostral ventromedial medulla connections in Cavia porcellus and their relation with tonic immobility defensive behavior: A biotinylated dextran amine neurotracing study. Neuroscience Letters, v. 535, p. 116-121, FEB 22 2013. (07/01174-1, 03/05038-4)

DE FREITAS, RENATO LEONARDO; SALGADO-ROHNER, CARLOS JOSE; CECILIO HALLAK, JAIME EDUARDO; DE SOUZA CRIPPA, JOSE ALEXANDRE; COIMBRA, NORBERTO CYSNE. Involvement of prelimbic medial prefrontal cortex in panic-like elaborated defensive behaviour and innate fear-induced antinociception elicited by GABA(A) receptor blockade in the dorsomedial and ventromedial hypothalamic nuclei: role of the endocannabinoid CB1 receptor. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, v. 16, n. 8, p. 1781-1798, SEP 2013. (03/05256-1, 07/01174-1, 01/03752-6, 09/54014-7, 02/01497-1, 12/03798-0, 09/17258-5)

CALVO, FABRICIO; ALMADA, RAFAEL CARVALHO; DOS ANJOS-GARCIA, TAYLLON; FALCONI-SOBRINHO, LUIZ LUCIANO; PASCHOALIN-MAURIN, TATIANA; BAZAGLIA-DE-SOUSA, GUILHERME; MEDEIROS, PRISCILA; DA SILVA, JULIANA ALMEIDA; LOBAO-SOARES, BRUNO; COIMBRA, NORBERTO CYSNE. Panicolytic-like effect of mu(1)-opioid receptor blockade in the inferior colliculus of prey threatened by Crotalus durissus terrificus pit vipers. JOURNAL OF PSYCHOPHARMACOLOGY, v. 33, n. 5, p. 577-588, MAY 2019. (04/10173-0, 09/02458-9, 13/10984-8, 02/13307-2, 17/11855-8, 17/13560-5, 12/25167-2, 12/03798-0, 07/01174-1, 15/10313-1, 12/22681-7)

MATIAS, JR., IVAIR; ELIAS, DAOUD HIBRAHIM; BERNARDINO GARCIA, CAMILA ARAUJO; SILVA, GUILHERME HENRIQUE; MEJIA, JORGE; CABRAL, FRANCISCO ROMERO; CAMARGO MIRANDA, ANA CLAUDIA; DA SILVA, SERGIO GOMES; LOPES, LUIZA DA SILVA; COIMBRA, NORBERTO CYSNE; et al. A new model of experimental hemispherotomy in young adult Rattus norvegicus: a neural tract tracing and SPECT in vivo study. JOURNAL OF NEUROSURGERY, v. 130, n. 4, p. 1210-1223, APR 2019. (07/01174-1, 17/11855-8, 02/01497-1, 12/03798-0)

CALVO, FABRICIO; ALMADA, RAFAEL CARVALHO; DA SILVA, JULIANA ALMEIDA; MEDEIROS, PRISCILA; SOARES, JR., RAIMUNDO DA SILVA; DE PAIVA, YARA BEZERRA; RONCON, CAMILA MARRONI; COIMBRA, NORBERTO CYSNE. The Blockade of mu(1)- and kappa-Opioid Receptors in the Inferior Colliculus Decreases the Expression of Panic Attack-Like Behaviours Induced by Chemical Stimulation of the Dorsal Midbrain. NEUROPSYCHOBIOLOGY, v. 78, n. 4, p. 218-228, NOV 2019. (09/54014-7, 02/13307-2, 12/23238-0, 15/10313-1, 09/02458-9, 07/01174-1, 04/10173-0, 12/25167-2, 12/03798-0, 02/01497-1, 17/13560-5, 12/22681-7)

ULLAH, FARHAD; DOS ANJOS-GARCIA, TAYLLON; MENDES-GOMES, JOYCE; HIBRAHIM ELIAS-FILHO, DAOUD; FALCONI-SOBRINHO, LUIZ LUCIANO; DE FREITAS, RENATO LEONARDO; KHAN, ASMAT ULLAH; DE OLIVEIRA, RICARDO; COIMBRA, NORBERTO CYSNE. Connexions between the dorsomedial division of the ventromedial hypothalamus and the dorsal periaqueductal grey matter are critical in the elaboration of hypothalamically mediated panic-like behaviour. Behavioural Brain Research, v. 319, p. 135-147, FEB 15 2017. (14/11869-0, 07/01174-1, 03/05256-1, 01/03752-6, 11/09850-1, 02/01497-1, 12/03798-0, 13/13398-2, 09/17258-5, 13/12916-0, 13/10984-8)

DOS ANJOS-GARCIA, TAYLLON; COIMBRA, NORBERTO CYSNE. Anandamide in the anterior hypothalamus diminishes defensive responses elicited in mice threatened by Epicrates cenchria constrictor serpents. ACTA NEUROBIOLOGIAE EXPERIMENTALIS, v. 80, n. 2, p. 179-191, 2020. (17/11855-8, 07/01174-1, 12/03798-0, 17/22647-7)

FALCONI-SOBRINHO, LUIZ LUCIANO; DOS ANJOS-GARCIA, TAYLLON; HERNANDES, PALOMA MOLINA; RODRIGUES, BRUNO MANGILI DE PAULA; ALMADA, RAFAEL CARVALHO; COIMBRA, NORBERTO CYSNE. Unravelling the dorsal periaqueductal grey matter NMDA receptors relevance in the nitric oxide-mediated panic-like behaviour and defensive antinociception organised by the anterior hypothalamus of male mice. Psychopharmacology, v. N/A, p. 17-pg., 2023-01-17. (17/22647-7, 12/22681-7, 17/11855-8, 07/01174-1, 19/01713-7, 18/03898-1, 13/10984-8, 20/15050-7, 12/03798-0)

FALCONI-SOBRINHO, LUIZ LUCIANO; DOS ANJOS-GARCIA, TAYLLON; ELIAS-FILHO, DAOUD HIBRAHIM; COIMBRA, NORBERTO CYSNE. Unravelling cortico-hypothalamic pathways regulating unconditioned fear-induced antinociception and defensive behaviours. Neuropharmacology, v. 113, p. 19-pg., 2017-02-01. (12/03798-0, 07/01174-1, 13/10984-8, 02/01497-1)

BIAGIONI, AUDREY FRANCISCO; DOS ANJOS-GARCIA, TAYLLON; ULLAH, FARHAD; FISHER, ISAAC RENE; FALCONI-SOBRINHO, LUIZ LUCIANO; DE FREITAS, RENATO LEONARDO; FELIPPOTTI, TATIANA TOCCHINI; COIMBRA, NORBERTO CYSNE. Neuroethological validation of an experimental apparatus to evaluate oriented and non-oriented escape behaviours: Comparison between the polygonal arena with a burrow and the circular enclosure of an open-field test. Behavioural Brain Research, v. 298, p. 13-pg., 2016-02-01. (14/10742-7, 03/05256-1, 12/03798-0, 13/10984-8, 09/17258-5, 08/08955-1, 11/06036-1, 02/01497-1, 01/03752-6, 11/05821-7, 07/01174-1)

FALCONI-SOBRINHO, LUIZ LUCIANO; DOS ANJOS-GARCIA, TAYLLON; ELIAS-FILHO, DAOUD HIBRAHIM; COIMBRA, NORBERTO CYSNE. Unravelling cortico-hypothalamic pathways regulating unconditioned fear-induced antinociception and defensive behaviours. Neuropharmacology, v. 113, n. A, p. 367-385, FEB 2017. (07/01174-1, 13/10984-8, 02/01497-1, 12/03798-0)

BIAGIONI, AUDREY FRANCISCO; DOS ANJOS-GARCIA, TAYLLON; ULLAH, FARHAD; FISHER, ISAAC RENE; FALCONI-SOBRINHO, LUIZ LUCIANO; DE FREITAS, RENATO LEONARDO; FELIPPOTTI, TATIANA TOCCHINI; COIMBRA, NORBERTO CYSNE. Neuroethological validation of an experimental apparatus to evaluate oriented and non-oriented escape behaviours: Comparison between the polygonal arena with a burrow and the circular enclosure of an open-field test. Behavioural Brain Research, v. 298, n. B, p. 65-77, FEB 1 2016. (03/05256-1, 14/10742-7, 01/03752-6, 08/08955-1, 11/05821-7, 07/01174-1, 02/01497-1, 12/03798-0, 09/17258-5, 13/10984-8, 11/06036-1)

SOARES JR, RAIMUNDO DA SILVA; FALCONI-SOBRINHO, LUIZ LUCIANO; DOS ANJOS-GARCIA, TAYLLON; COIMBRA, NORBERTO CYSNE. 5-Hydroxytryptamine 2A receptors of the dorsal raphe nucleus modulate panic-like behaviours and mediate fear-induced antinociception elicited by neuronal activation in the central nucleus of the inferior colliculus. Behavioural Brain Research, v. 357, n. SI, p. 71-81, JAN 14 2019. (07/01174-1, 02/01497-1, 12/03798-0)

DA SILVA, JULIANA ALMEIDA; DE FREITAS, RENATO LEONARDO; DUTRA EICHENBERGER, GUSTAVO CAVALCANTI; PADOVAN, CLAUDIA MARIA; COIMBRA, NORBERTO CYSNE. Chemical neuroanatomical and psychopharmacological evidence that kappa receptor-mediated endogenous opioid peptide neurotransmission in the dorsal and ventral mesencephalon modulates panic-like behaviour. European Journal of Pharmacology, v. 698, n. 1-3, p. 235-245, JAN 5 2013. (09/02458-9, 03/05256-1, 07/01174-1, 01/03752-6, 09/54014-7, 02/01497-1, 09/17258-5)

PASCHOALIN-MAURIN, TATIANA; DOS ANJOS-GARCIA, TAYLLON; FALCONI-SOBRINHO, LUIZ LUCIANO; DE FREITAS, RENATO LEONARDO; CYSNE COIMBRA, JADE PISSAMIGLIO; LAURE, CARLOS JULIO; COIMBRA, NORBERTO CYSNE. The Rodent-versus-wild Snake Paradigm as a Model for Studying Anxiety- and Panic-like Behaviors: Face, Construct and Predictive Validities. Neuroscience, v. 369, p. 336-349, JAN 15 2018. (03/05256-1, 17/11855-8, 01/03752-6, 07/01174-1, 02/01497-1, 12/03798-0, 09/17258-5)

DE FREITAS, RENATO LEONARDO; BOLOGNESI, LUANA IACOVELO; TWARDOWSCHY, ANDRE; AGUIAR CORREA, FERNANDO MORGAN; SIBSON, NICOLA R.; COIMBRA, NORBERTO CYSNE. Neuroanatomical and neuropharmacological approaches to postictal antinociception-related prosencephalic neurons: the role of muscarinic and nicotinic cholinergic receptors. BRAIN AND BEHAVIOR, v. 3, n. 3, p. 286-301, MAY 2013. (11/20381-3, 03/05256-1, 02/01496-5, 96/08574-9, 01/03752-6, 08/00531-8, 07/01174-1)

COIMBRA, NORBERTO CYSNE; CALVO, FABRICIO; ALMADA, RAFAEL CARVALHO; FREITAS, RENATO LEONARDO; PASCHOALIN-MAURIN, TATIANA; DOS ANJOS-GARCIA, TAYLLON; ELIAS-FILHO, DAOUD HIBRAHIM; UBIALI, WALTER ADRIANO; LOBAO-SOARES, BRUNO; TRACEY, IRENE. OPIOID NEUROTRANSMISSION MODULATES DEFENSIVE BEHAVIOR AND FEAR-INDUCED ANTINOCICEPTION IN DANGEROUS ENVIRONMENTS. Neuroscience, v. 354, p. 178-195, JUN 23 2017. (03/01768-8, 03/01794-9, 04/10173-0, 02/13307-2, 02/01497-1, 12/03798-0, 07/01174-1, 03/07202-6, 12/22681-7)

ULLAH, FARHAD; DOS ANJOS-GARCIA, TAYLLON; DOS SANTOS, IEDA REGINA; BIAGIONI, AUDREY FRANCISCO; COIMBRA, NORBERTO CYSNE. Relevance of dorsomedial hypothalamus, dorsomedial division of the ventromedial hypothalamus and the dorsal periaqueductal gray matter in the organization of freezing or oriented and non-oriented escape emotional behaviors. Behavioural Brain Research, v. 293, p. 143-152, OCT 15 2015. (14/10742-7, 08/08955-1, 02/01497-1, 12/03798-0, 07/01174-1)

SOARES, JR., RAIMUNDO DA SILVA; FALCONI-SOBRINHO, LUIZ LUCIANO; ALMADA, RAFAEL CARVALHO; COIMBRA, NORBERTO CYSNE. Dorsal raphe nucleus 5-Hydroxytryptamine 2A receptors are critical for the organisation of panic attack-like defensive behaviour and unconditioned fear-induced antinociception elicited by the chemical stimulation of superior colliculus neurons. European Neuropsychopharmacology, v. 29, n. 7, p. 858-870, JUL 2019. (07/01174-1, 12/03798-0)

BIAGIONI, AUDREY FRANCISCO; DE FREITAS, RENATO LEONARDO; DA SILVA, JULIANA ALMEIDA; DE OLIVEIRA, RITHIELE CRISTINA; DE OLIVEIRA, RICARDO; ALVES, VANI MARIA; COIMBRA, NORBERTO CYSNE. Serotonergic neural links from the dorsal raphe nucleus modulate defensive behaviours organised by the dorsomedial hypothalamus and the elaboration of fear-induced antinociception via locus coeruleus pathways. Neuropharmacology, v. 67, p. 379-394, APR 2013. (09/02458-9, 03/05256-1, 08/08955-1, 01/03752-6, 07/01174-1, 09/54014-7, 02/01497-1, 12/03798-0, 09/17258-5)

ALMADA, RAFAEL C.; FALCONI-SOBRINHO, LUIZ LUCIANO; DA SILVA, JULIANA A.; WOTJAK, CARSTEN T.; COIMBRA, NORBERTO C.. Augmented anandamide signalling in the substantia nigra pars reticulata mediates panicolytic-like effects in mice confronted by Crotalus durissus terrificus pit vipers. Psychopharmacology, v. N/A, p. 17-pg., 2022-06-02. (17/11855-8, 07/01174-1, 20/15050-7, 12/03798-0)

URIBE-MARINO, ANDRES; CASTIBLANCO-URBINA, MARIA ANGELICA; FALCONI-SOBRINHO, LUIZ LUCIANO; DOS ANJOS-GARCIA, TAYLLON; DE OLIVEIRA, RITHIELE CRISTINA; MENDES-GOMES, JOYCE; SOARES, JR., RAIMUNDO DA SILVA; MATTHIESEN, MELINA; ALMADA, RAFAEL CARVALHO; DE OLIVEIRA, RICARDO; et al. The alpha- and beta-noradrenergic receptors blockade in the dorsal raphe nucleus impairs the panic-like response elaborated by medial hypothalamus neurons. Brain Research, v. 1725, DEC 15 2019. (09/54014-7, 07/01174-1)

PASCHOALIN-MAURIN, TATIANA. Repeated exposure of naive and peripheral nerve-injured mice to a snake as an experimental model of post-traumatic stress disorder and its co-morbidity with neuropathic pain. Brain Research, v. 1744, OCT 1 2020. (17/11855-8, 07/01174-1, 13/13398-2, 12/03798-0)

ALMADA, RAFAEL CARVALHO; DOS ANJOS-GARCIA, TAYLLON; DA SILVA, JULIANA ALMEIDA; PIGATTO, GLAUCE REGINA; WOTJAK, CARSTEN T.; COIMBRA, NORBERTO CYSNE. The modulation of striatonigral and nigrotectal pathways by CB1 signalling in the substantia nigra pars reticulata regulates panic elicited in mice by urutu-cruzeiro lancehead pit vipers. Behavioural Brain Research, v. 401, MAR 5 2021. (07/01174-1, 12/03798-0, 17/11855-8)

DA SILVA, JULIANA ALMEIDA; ALMADA, RAFAEL CARVALHO; DE PAIVA, YARA BEZERRA; COIMBRA, NORBERTO CYSNE. Endocannabinoid neuromodulation in the neostriatum decreases the GABAergic striato-nigral disinhibitory function and increases the nigro-collicular inhibitory pathway activity. JOURNAL OF NEURAL TRANSMISSION, v. 127, n. 8, JUN 2020. (02/01497-1, 19/01713-7, 17/11855-8, 15/10313-1, 09/02458-9, 07/01174-1, 12/03798-0, 18/03898-1, 12/22681-7)

SILVA, JULIANA ALMEIDA DA; ALMADA, RAFAEL CARVALHO; FALCONI-SOBRINHO, LUIZ LUCIANO; PIGATTO, GLAUCE REGINA; HERNANDES, PALOMA MOLINA; COIMBRA, NORBERTO CYSNE. Neostriatum neuronal TRPV1-signalling mediates striatal anandamide at high concentration facilitatory influence on neostriato-nigral dishinhibitory GABAergic connections. Brain Research Bulletin, v. 192, p. 14-pg., 2023-01-01. (20/15050-7, 07/01174-1, 12/03798-0)

SOARES JR, RAIMUNDO DA SILVA; FALCONI-SOBRINHO, LUIZ LUCIANO; DOS ANJOS-GARCIA, TAYLLON; COIMBRA, NORBERTO CYSNE. 5-Hydroxytryptamine 2A receptors of the dorsal raphe nucleus modulate panic-like behaviours and mediate fear-induced antinociception elicited by neuronal activation in the central nucleus of the inferior colliculus. Behavioural Brain Research, v. 357, p. 11-pg., 2019-01-14. (12/03798-0, 07/01174-1, 02/01497-1)

DOS ANJOS-GARCIA, TAYLLON; ULLAH, FARHAD; FALCONI-SOBRINHO, LUIZ LUCIANO; COIMBRA, NORBERTO CYSNE. CB1 cannabinoid receptor-mediated anandamide signalling reduces the defensive behaviour evoked through GABA(A) receptor blockade in the dorsomedial division of the ventromedial hypothalamus. Neuropharmacology, v. 113, p. 11-pg., 2017-02-01. (13/10984-8, 02/01497-1, 09/54014-7, 12/03798-0, 07/01174-1)

DA SILVA, JULIANA ALMEIDA; ALMADA, RAFAEL CARVALHO; DE FIGUEIREDO, REBECA MACHADO; COIMBRA, NORBERTO CYSNE. Blockade of synaptic activity in the neostriatum and activation of striatal efferent pathways produce opposite effects on panic attack-like defensive behaviours evoked by GABAergic disinhibition in the deep layers of the superior colliculus. Physiology & Behavior, v. 196, p. 104-111, NOV 1 2018. (07/01174-1, 15/10313-1, 09/02458-9, 12/03798-0, 12/22681-7, 02/01497-1, 09/54014-7)

FERREIRA-SGOBBI, RENATA; FIGUEIREDO, REBECA MACHADO; FRIAS, ALANA TERCINO; MATTHIESEN, MELINA; BATISTELA, MATHEUS FITIPALDI; FALCONI-SOBRINHO, LUIZ LUCIANO; VILELA-COSTA, HELOISA HELENA; SA, SUSANA ISABEL; LOVICK, THELMA ANDERSON; ZANGROSSI JR, HELIO; et al. Panic-like responses of female Wistar rats confronted by Bothrops alternatus pit vipers, or exposure to acute hypoxia: Effect of oestrous cycle. European Journal of Neuroscience, v. 55, n. 1, DEC 2021. (12/03798-0, 17/11855-8, 07/01174-1)

FALCONI-SOBRINHO, LUIZ LUCIANO; DOS ANJOS-GARCIA, TAYLLON; DE OLIVEIRA, RICARDO; COIMBRA, NORBERTO CYSNE. Decrease in NMDA receptor-signalling activity in the anterior cingulate cortex diminishes defensive behaviour and unconditioned fear-induced antinociception elicited by GABAergic tonic inhibition impairment in the posterior hypothalamus. European Neuropsychopharmacology, v. 27, n. 11, p. 1120-1131, NOV 2017. (07/01174-1, 17/11855-8, 12/03798-0)

BIAGIONI, AUDREY FRANCESCHI; DE OLIVEIRA, RITHIELE CRISTINA; DE OLIVEIRA, RICARDO; DA SILVA, JULIANA ALMEIDA; DOS ANJOS-GARCIA, TAYLION; RONCON, CAMILA MARRONI; CORRADO, ALEXANDRE PINTO; ZANGROSSI, JR., HELIO; COIMBRA, NORBERTO CYSNE. 5-Hydroxytryptamine(1A) receptors in the dorsomedial hypothalamus connected to dorsal raphe nucleus inputs modulate defensive behaviours and mediate innate fear-induced antinociception. European Neuropsychopharmacology, v. 26, n. 3, p. 532-545, MAR 2016. (11/09850-1, 14/10742-7, 08/08955-1, 07/01174-1, 12/03798-0, 12/23238-0)

DOS ANJOS-GARCIA, TAYLLON; KANASHIRO, ALEXANDRE; DE CAMPOS, ALLINE CRISTINA; COIMBRA, NORBERTO CYSNE. Environmental Enrichment Facilitates Anxiety in Conflict-Based Tests but Inhibits Predator Threat-Induced Defensive Behaviour in Male Mice. NEUROPSYCHOBIOLOGY, v. N/A, p. 12-pg., 2022-01-13. (17/11855-8, 07/01174-1, 20/15050-7, 12/03798-0)