New quiral metal catalysts and their applications in asymmetric catalysis

• Grant number: 18/01669-5
• Support Opportunities: Research Grants - Young Investigators Grants
• Start date: May 01, 2018
• End date: October 31, 2023
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Caio Costa Oliveira
• Grantee: Caio Costa Oliveira
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated scholarship(s): 23/11021-0 - Remote functionalization by terminal olefin monotransposition, catalyzed by nickel under kinetic control, BP.DD; 23/10646-7 - Synthesis of enantioenriched helical complexes, BP.DD; 20/12435-5 - Synthesis of new enantioenriched half-sandwich ligands and its applications to enantioselective ruthenium-catalyzed C-H functionalization reactions, BP.DD; + associated scholarships 19/15883-1 - Synthesis and catalytic activity of enantioenriched complexes bearing bisfunctional ligands, BP.DD; 19/00080-0 - Synthesis and catalytic activity of metal complexes bearing enantioenriched sulphoxides ligands, BP.DD; 18/18490-8 - New chiral ruthenium complexes and their applications in asymmetric catalysis, BP.MS - associated scholarships

Abstract

Catalytic methods for the synthesis of enantiomerically pure compounds are of great importance for the preparation of pharmacologically active substances and for Fine Chemicals. The rational development of enantioenriched ligands allows the preferential preparation of one of the two enantiomeric products in reactions catalyzedby transition metals. The main topic of this research project is the development of new classes of enantioenriched ligands and their use on the synthesis of new chiral metal complexes. More specifically, it will cover two research lines: 1) the design of chiral half-sandwich complexes and its application for asymmetric transformations; 2) the synthesis of new ligands able to coordinate simultaneously to two metals (or a metal and a Lewis acid) and use them to create novel process involving, at least, a sequence of two distinct reactions. The success of this project will allow the development of a new research field in asymmetric catalysis. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

OLIVEIRA, CAIO C.; DUARTE CORREIA, CARLOS ROQUE. Enantioselective Heck-Matsuda Reactions: From Curiosity to a Game-Changing Methodology. CHEMICAL RECORD, JUN 2021. (13/07600-3, 14/25770-6, 18/01669-5)

SCALON, LUCAS; SZOSTAK, RODRIGO; ARAUJO, FRANCINEIDE L.; ADRIANI, KARLA F.; SILVEIRA, JULIAN F. R., V; OLIVEIRA, WILLIAN X. C.; DA SILVA, JUAREZ L. F.; OLIVEIRA, CAIO C.; NOGUEIRA, ANA FLAVIA. Improving the Stability and Efficiency of Perovskite Solar Cells by a Bidentate Anilinium Salt. JACS AU, v. 2, n. 6, p. 7-pg., 2022-06-27. (18/01669-5, 17/11631-2, 20/04406-5, 20/14451-8, 17/12582-5, 19/08257-7, 18/21401-7, 18/11152-0, 14/25770-6)

DE SOUZA, EDSON LEONARDO SCARPA; OLIVEIRA, CAIO C.. Selective Radical Transformations with Aryldiazonium Salts. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, v. 26, n. 12, p. 23-pg., 2023-02-28. (18/01669-5, 14/25770-6, 19/25657-9)

OLIVEIRA, CAIO C.; CORREIA, CARLOS ROQUE D.. The palladium-catalyzed Heck arylation of olefins with arenediazonium salts as a sustainable strategy in organic synthesis. CURRENT OPINION IN GREEN AND SUSTAINABLE CHEMISTRY, v. 26, DEC 2020. (14/25770-6, 13/07600-3, 18/01669-5)

OLIVEIRA, CAIO C.; DUARTE CORREIA, CARLOS ROQUE. Enantioselective Heck-Matsuda Reactions: From Curiosity to a Game-Changing Methodology. CHEMICAL RECORD, v. 21, n. 10, SI, p. 2688-2701, OCT 2021. (18/01669-5, 13/07600-3, 14/25770-6)

SCALON, LUCAS; VAYNZOF, YANA; NOGUEIRA, ANA FLAVIA; OLIVEIRA, CAIO C.. How organic chemistry can affect perovskite photovoltaics. CELL REPORTS PHYSICAL SCIENCE, v. 4, n. 5, p. 21-pg., 2023-05-17. (17/11631-2, 21/12104-1, 18/01669-5, 18/21401-7, 20/04406-5, 14/25770-6)