Institutional research development plan of the Instituto Adolfo Lutz (PDIp)

• Grant number: 17/50333-7
• Support Opportunities: Research Grants - State Research Institutes Modernization Program
• Start date: April 01, 2018
• End date: March 31, 2024
• Field of knowledge: Health Sciences - Collective Health - Public Health
• Principal Investigator: Carlos Henrique Camargo
• Grantee: Carlos Henrique Camargo
• Host Institution: Instituto Adolfo Lutz (IAL). Coordenadoria de Controle de Doenças (CCD). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Pesquisadores principais:( Últimos ): Carlos Roberto Prudencio ; Maria Do Carmo Sampaio Tavares Timenetsky ; Paula Ordonhez Rigato
• Pesquisadores principais:( Antigos ): André Gustavo Tempone Cardoso ; José Eduardo Tolezano ; Marcia de Souza Carvalho Melhem
• Associated research grant(s): 20/16662-6 - Evaluation of the Xpert Carba-R molecular rapid test in the active search for carbapenem-resistant bacteria in hospitalized patients, AP.PP; 20/12585-7 - Evaluation of whole genome sequencing for diagnosis of drug resistant tuberculosis in patients of Sao Paulo State, AP.PP; 18/14384-9 - Identification and characterization of acute cases of Human Immunodeficiency Virus (HIV-1) infection, AP.PP; + associated grants 18/25889-4 - Technological innovations in health for the diagnosis and control of Visceral Leishmaniosis in the municipality of Bauru, State of São Paulo, Brazil, AP.PP; 18/21192-9 - Multi-User Equipment approved in grant 2017/50333-7: MALDI-TOF, AP.EMU; 18/21191-2 - Multi-User Equipment approved in grant 2017/50333-7: flow cytometer, AP.EMU; 18/21193-5 - Multi-user equipment approved in grant 2017/50333-7: genetic analyzer, AP.EMU - associated grants
• Associated scholarship(s): 23/06453-9 - Construction and selection of a scFv monoclonal antibody library against the spike protein of SARS-CoV-2 variants of concern by Phage Display technology, BP.TT; 22/05550-8 - Construction and selection of a library of scFv monoclonal antibodies against the spike protein of SARS-CoV-2 variants of concern by Phage Display technology, BP.TT; 22/05252-7 - Determination of resistance to fluconazole and caspofungin in clinical isolates of Candida parapsilosis and customization of the bank for time-of-flight laser-assisted matrix ionization/desorption mass spectrometry (MALDI-TOF MS), BP.TT; + associated scholarships 21/02608-2 - Construction and selection of a library of scFv monoclonal antibodies against SARS-CoV-2 spike protein by phage display technology, BP.PD; 21/01496-6 - Investigation of CD4 and CD8 T cells profiles using multicolour flow cytometry to biomarkers identification on latent tuberculosis, BP.MS; 20/03637-3 - Study of new drug candidates for neglected protozoan diseases, BP.PD; 19/22246-8 - The use of geotechnologies in health: spatial analysis of laboratory-based surveillance phenomena: Leishmaniases in São Paulo State, Brazil, BP.PD; 18/18996-9 - Cryptic Candida species among bloodstream isolates: identification and susceptibility pattern to azole drugs, BP.MS - associated scholarships

Abstract

IAL has established itself as a reference institution in Public Health, developing scientific research and performing analytical procedures for diagnostic elucidation and sanitary control, rapidly addressing the demands of Health Surveillance of the different regions of the State of Sao Paulo and other units of the federation. The data regarding the IAL scientific-technical production (services, publications, continuing education, and professional training) in the last 5 years have indicated that the institution performance is consistent with its mission, as part of the Health Surveillance System of the State of Sao Paulo, and convergent to the priorities established on 2016-2019 PES (State Plan for Health), producing satisfactory results in the areas of concentration of such demands. The IAL Research Institutional Development Plan intends to be an auxiliary resource for planning and management, aiming to encourage the development of laboratory researches and contribute to the integrity of government actions for the protection, prevention and promotion of health, and improvement of the quality of life for the population. The chosen strategy lies on the development of technological units, enabling the implementation of advanced methodologies for the study of incidence and biological diversity of pathogens, identification of biomarkers in health events/diseases, and assessment of food/water safety of relevance to Public Health. The research grants and infrastructure resources requested in this plan will be allocated for structuring of the following units: bioinformatics, georeferencing, and next-generation sequencing, and also to enhance units such as flow cytometry, chromatography, and spectrometry. Together, these units will allow IAL to offer better conditions for the provision of public services and generation of research in its operational field. With the accomplishment of the projects presented here, we expect to establish new research lines, gain expertise, generate high quality human resources, and strengthen competencies to keep IAL as a Center of Excellence and Reference in Epidemiological, Sanitary and Environmental Surveillance, operating at the forefront of science, technology and resulting in suitable technological solutions to the challenges in Public Health. (AU)

Scientific publications

(32)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MELHEM, MARCIA S. C.; COELHO, VIVIAN C.; FONSECA, CLAUDIA A.; DE OLIVEIRA, LIDIANE; BONFIETTI, LUCAS X.; SZESZS, MARIA W.; MAGRI, MARCELLO M. C.; DORNELES, FRANCINE S.; TAGUCHI, HIDEAKI; MOREIRA, DANIEL V. S.; et al. Evaluation of the Sensititre YeastOne and Etest in Comparison with CLSI M38-A2 for Antifungal Susceptibility Testing of Three Azoles, Amphotericin B, Caspofungin, and Anidulafungin, against Aspergillus fumigatus and Other Species, Using New Clinical Breakpoints and Epidemiological Cutoff Values. PHARMACEUTICS, v. 14, n. 10, p. 15-pg., 2022-10-01. (12/50212-1, 17/50333-7)

CAMARGO, CARLOS HENRIQUE. Current status of NDM-producing Enterobacterales in Brazil: a narrative review. Brazilian Journal of Microbiology, v. N/A, p. 6-pg., 2022-06-11. (17/50333-7, 20/06157-2)

SANTOS, FELIPE ROCHA DA SILVA; DE AZEVEDO, MARCELA SANTIAGO PACHECO; BIELAVSKY, MONICA; DA COSTA, HERNAN HERMES MONTEIRO; RIBEIRO, DANIELA GOMES; DO NASCIMENTO, GLEIDSON GUEDES; PAZ MARCONDES, GABRIELLE MENEZES; DE CASTRO, BEATRIZ PORTUGAL; DE LIMA NETO, DANIEL FERREIRA; PRUDENCIO, CARLOS ROBERTO. Mutational profile confers increased stability of SARS-CoV-2 spike protein in Brazilian isolates. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, v. 40, n. 23, p. 6-pg., 2022-01-01. (17/50333-7)

DE JESUS BERTANI, AMANDA MARIA; VIEIRA CUNHA, MARCOS PAULO; DE CARVALHO, ENEAS; ARAUJO, LEONARDO TADEU; DOS SANTOS, CARLA ADRIANA; AMARANTE, ARIADNE FERREIRA; REIS, ALEX DOMINGOS; DE ALMEIDA, ELISABETE APARECIDA; CAMPOS, KAROLINE RODRIGUES; SACCHI, CLAUDIO TAVARES; et al. Genomic characterization of a multi-drug resistant, CTX-M-65-producing clinical isolate of Salmonella Infantis isolated in Brazil. Microbes and Infection, v. 24, n. 5, p. 4-pg., 2022-06-30. (17/50333-7)

CARMONA, RITA C. C.; MACHADO, BRAULIO C.; REIS, FABRICIO C.; JORGE, ADRIANA M. V.; CILLI, AUDREY; DIAS, AMANDA M. N.; MORAIS, DANIELE R.; LEME, LUCAS; YU, ANA L. F.; SILVA, MARCELA R.; et al. Hand, foot, and mouth disease outbreak by Coxsackievirus A6 during COVID-19 pandemic in 2021, Sao Paulo, Brazil. Journal of Clinical Virology, v. 154, p. 4-pg., 2022-07-24. (17/50333-7, 17/05350-0)

DA COSTA, HERNAN H. M.; BIELAVSKY, MONICA; ORTS, DIEGO J. B.; ARAUJO, SERGIO; ADRIANI, PATRICIA P.; NOGUEIRA, JULIANA S.; ASTRAY, RENATO M.; PANDEY, RAMENDRA P.; LANCELLOTTI, MARCELO; CUNHA-JUNIOR, JAIR P.; et al. Production of Recombinant Zika Virus Envelope Protein by Airlift Bioreactor as a New Subunit Vaccine Platform. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 24, n. 18, p. 25-pg., 2023-09-01. (22/07256-0, 21/11936-3, 17/50333-7)

FURUSATO, ISABELLA NAOMI; FIGUEIREDO, KETLYN BOLSACHINI; DE CARVALHO, ANA CAROLINA SOUZA RAMOS; FERREIRA, CAMILA SANTOS DA SILVA; TAKAHASHI, JULIANA POSSATTO FERNANDES; KIMURA, LIDIA MIDORI; ALEIXO, CAMILA SIQUEIRA; DE BRITO, ODILIA PEREIRA; LUCHS, ADRIANA; CUNHA, MARIANA SEQUETIN; et al. Detection of herpesviruses in neotropical primates from Sao Paulo, Brazil. Brazilian Journal of Microbiology, v. N/A, p. 9-pg., 2023-09-09. (17/50333-7, 20/14786-0)

PRUDENCIO, CARLOS ROBERTO; DA COSTA, VIVALDO GOMES; ROCHA, LETICIA BARBOZA; DA COSTA, HERNAN HERMES MONTEIRO; ORTS, DIEGO JOSE BELATO; SANTOS, FELIPE ROCHA DA SILVA; RAHAL, PAULA; LINO, NIKOLAS ALEXANDER BORSATO; DA CONCEICAO, PAMELA JOYCE PREVIDELLI; BITTAR, CINTIA; et al. Identification of Zika Virus NS1-Derived Peptides with Potential Applications in Serological Tests. Viruses-Basel, v. 15, n. 3, p. 20-pg., 2023-03-01. (16/20045-7, 16/16188-7, 17/50333-7, 16/23560-0, 15/17178-2, 16/05570-8, 17/24769-2)

AMARAL, MAIARA; ASIKI, HANNAH; SEAR, CLAIRE E.; SINGH, SNIGDHA; PIEPER, PAULINE; HAUGLAND, MARIUS M.; ANDERSON, EDWARD A.; TEMPONE, ANDRE G.. Biological activity and structure-activity relationship of dehydrodieugenol B analogues against visceral leishmaniasis. RSC MEDICINAL CHEMISTRY, v. 14, n. 7, p. 7-pg., 2023-05-26. (18/25128-3, 21/04464-8, 17/50333-7)

DA COSTA, HERNAN H. M.; ORTS, DIEGO J. B.; MOURA, ANDREW D.; DUARTE-NETO, AMARO N.; CIRQUEIRA, CINTHYA S.; RESSIO, RODRIGO A.; KANAMURA, CRISTINA T.; MIGUITA, KAREN; FERREIRA, JERENICE E.; SANTOS, RAIMUNDA T. M.; et al. RBD and Spike DNA-Based Immunization in Rabbits Elicited IgG Avidity Maturation and High Neutralizing Antibody Responses against SARS-CoV-2. Viruses-Basel, v. 15, n. 2, p. 16-pg., 2023-02-01. (17/50333-7)

RODRIGUES, DALITY KEFFELEN DE BARROS; LOCKHART, SHAWN R.; BERKOW, ELIZABETH L.; GADE, LALITHA; BONFIETTI, LUCAS XAVIER; GIMENES, VIVIANE MAZO FAVERO; RUIZ, LUCIANA SILVA; MACIONI, MILENA BRONZE; MELHEM, MARCIA DE SOUZA CARVALHO. Whole-genome sequencing of Candida haemulonii species complex from Brazil and the United States: Genetic diversity and antifungal susceptibility. Medical Mycology, v. 61, n. 4, p. 9-pg., 2023-04-03. (19/26037-4, 18/18996-9, 17/50333-7)

GALHARDO, THALITA S.; UENO, ANDERSON K.; CARVALHO, WAGNER A.; COSTA-SILVA, THAIS A.; GONCALVES, MARINA M.; ABIUZI, MARIANA B.; TEMPONE, ANDRE G.; LAGO, JOAO HENRIQUE G.; MANDELLI, DALMO; FISCHMEISTER, CEDRIC; et al. Synthesis of New Dehydrodieugenol Derivatives via Olefin Cross Metathesis and In Vitro Evaluation of Their Trypanocidal Activity. CATALYSTS, v. 13, n. 7, p. 13-pg., 2023-07-01. (21/12342-0, 21/04464-8, 18/10279-6, 17/50333-7, 21/02789-7, 18/01258-5, 18/07885-1)

CAMARGO, CARLOS HENRIQUE; YAMADA, AMANDA YAEKO; DE SOUZA, ANDREIA RODRIGUES; LIMA, MARISA DE JESUS DE CASTRO; CUNHA, MARCOS PAULO VIEIRA; FERRARO, PEDRO SMITH PEREIRA; SACCHI, CLAUDIO TAVARES; DOS SANTOS, MARLON BENEDITO NASCIMENTO; CAMPOS, KAROLINE RODRIGUES; TIBA-CASAS, MONIQUE RIBEIRO; et al. Genomics and Antimicrobial Susceptibility of Clinical Pseudomonas aeruginosa Isolates from Hospitals in Brazil. PATHOGENS, v. 12, n. 7, p. 11-pg., 2023-07-01. (18/21192-9, 17/50333-7, 19/21361-8)

MOREIRA TRAJANO, DEBORA THAIS; CARVALHO MELHEM, MARCIA DE SOUZA; FERNANDES TAKAHASHI, JULIANA POSSATTO; BONFIETTI, LUCAS XAVIER; DE ARAUJO, MIRIAM RANDO; CORREA, VIVIANE BARBOSA; DE OLIVEIRA ARAUJO, KARINA BASSETO; BARNABE, VIVIANI; FERNANDES, CAROLINA GONCALVES. Species and antifungal susceptibility profile of agents causing vulvovaginal candidiasis in a military population: a cross-sectional study. Medical Mycology, v. 61, n. 3, p. 8-pg., 2023-03-02. (17/50333-7)

LEVATTI, ERICA V. DE CASTRO; COSTA-SILVA, THAIS A.; MORAIS, THIAGO R.; FERNANDES, JOAO PAULO S.; LAGO, JOAO HENRIQUE G.; TEMPONE, ANDRE G.. Lethal action of Licarin A derivatives in Leishmania (L.) infantum Imbalance of calcium and bioenergetic metabolism. Biochimie, v. 208, p. 10-pg., 2023-05-22. (21/02789-7, 21/04464-8, 17/50333-7)

CAMARGO, CARLOS HENRIQUE; YAMADA, AMANDA YAEKO; NAGAMORI, FILIPE ONISHI; DE SOUZA, ANDREIA RODRIGUES; TIBA-CASAS, MONIQUE RIBEIRO; DE MORAES FRANCA, FLAVIA APARECIDA; TRIGUEIRO NOBREGA PORTO, MARIA HELENA; DE LIMA GARZON, MAGDA LOURDES; HIGGINS, PAUL; MADALOSSO, GERALDINE; et al. Clonal spread of ArmA- and OXA-23-coproducing Acinetobacter baumannii International Clone 2 in Brazil during the first wave of the COVID-19 pandemic. Journal of Medical Microbiology, v. 71, n. 4, p. 6-pg., 2022-01-01. (17/16988-6, 20/06157-2, 17/50333-7, 18/21192-9, 18/21193-5)

YAMADA, AMANDA YAEKO; DE SOUZA, ANDREIA RODRIGUES; DE CASTRO LIMA, MARISA DE JESUS; REIS, ALEX DOMINGOS; CAMPOS, KAROLINE RODRIGUES; DE JESUS BERTANI, AMANDA MARIA; TADEU DE ARAUJO, LEONARDO JOSE; SACCHI, CLAUDIO TAVARES; TIBA-CASAS, MONIQUE RIBEIRO; CAMARGO, CARLOS HENRIQUE. Co-production of Classes A and B Carbapenemases BKC-1 and VIM-2 in a Clinical Pseudomonas Putida Group Isolate from Brazil. Current Microbiology, v. 79, n. 9, p. 5-pg., 2022-09-01. (17/50333-7, 18/21193-5, 18/21192-9)

MOURA, ANDREW D.; DA COSTA, HERNAN H. M.; CORREA, VICTOR A.; LIMA, ANA K. DE S.; LINDOSO, JOSE A. L.; DE GASPARI, ELIZABETH; HONG, MARISA A.; CUNHA-JUNIOR, JAIR P.; PRUDENCIO, CARLOS R.. Assessment of avidity related to IgG subclasses in SARS-CoV-2 Brazilian infected patients. SCIENTIFIC REPORTS, v. 11, n. 1, SEP 3 2021. (17/50333-7, 18/04202-0)

CAMARGO, CARLOS HENRIQUE; GONCALVES, CLAUDIA REGINA; GOMES PAGNOCA, ERICA VALESSA RAMOS; CAMPOS, KAROLINE RODRIGUES; MARTINS MONTANHA, JANAINA OLHER; PINHEIRO FLORES, MARICELIA NAVARRO; COSTA NUNES SOARES, MARCIA MARIA; TOLENTINO BINHARDI, FERNANDA MODESTO; FERREIRA, PATRICIA MARQUES; FRUGIS YU, ANA LUCIA; et al. SARS-CoV-2 reinfection in a healthcare professional in inner Sao Paulo during the first wave of COVID-19 in Brazil. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, v. 101, n. 4, DEC 2021. (17/50333-7, 18/21193-5)

CAMARGO, CARLOS HENRIQUE; YAMADA, AMANDA YAEKO; DE SOUZA, ANDREIA RODRIGUES; REIS, ALEX DOMINGOS; NASCIMENTO SANTOS, MARLON BENEDITO; DE ASSIS, DENISE BRANDAO; DE CARVALHO, ENEAS; TAKAGI, ELIZABETH HARUMMYY; VIEIRA CUNHA, MARCOS PAULO; TIBA-CASAS, MONIQUE RIBEIRO. Genomic Diversity of NDM-Producing Klebsiella Species from Brazil, 2013-2022. ANTIBIOTICS-BASEL, v. 11, n. 10, p. 9-pg., 2022-10-01. (20/06157-2, 17/50333-7)

SUELI APARECIDA FERNANDES; ANA TEREZINHA TAVECHIO; ÂNGELA CRISTINA RODRIGUES GHILARDI; ELISABETE APARECIDA DE ALMEIDA; JOSEFA MARIA LOPES DA SILVA; CARLOS HENRIQUE CAMARGO; MONIQUE RIBEIRO TIBA-CASAS. Salmonella enterica serotypes from human and nonhuman sources in Sao Paulo State, Brazil, 2004-2020. Revista do Instituto de Medicina Tropical de São Paulo, v. 64, 2022-09-30. (17/50333-7)

TEMPONE, ANDRE GUSTAVO; DOS SANTOS THEODORO, REINALDO; ROMANELLI, MAIARA MARIA; FERREIRA, DAYANA AGNES SANTOS; AMARAL, MAIARA; DE ASSIS, LETICIA RIBEIRO; CRUZ, LUCAS MONTEIRO SANTA; COSTA, ALAN ROBERTO; ZANELLA, ROSEMEIRE COBO; CHRISTODOULIDES, MYRON; et al. A new reduced chalcone-derivative affects the membrane permeability and electric potential of multidrug-resistant Enterococcus faecalis. Chemico-Biological Interactions, v. 365, p. 8-pg., 2022-08-10. (14/18330-0, 21/04464-8, 18/26655-7, 19/11979-4, 17/50333-7, 18/15083-2, 09/53989-4)

DA SILVA SANTOS, FELIPE ROCHA; PACHECO DE AZEVEDO, MARCELA SANTIAGO; BIELAVSKY, MONICA; MONTEIRO DA COSTA, HERNAN HERMES; RIBEIRO, DANIELA GOMES; DO NASCIMENTO, GLEIDSON GUEDES; PAZ MARCONDES, GABRIELLE MENEZES; DE CASTRO, BEATRIZ PORTUGAL; DE LIMA NETO, DANIEL FERREIRA; PRUDENCIO, CARLOS ROBERTO. Mutational profile confers increased stability of SARS-CoV-2 spike protein in Brazilian isolates. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, SEP 2021. (17/50333-7)

YAMADA, AMANDA YAEKO; SANTOS, ALESSANDRO MARQUES DOS; SOUZA, ANDREIA RODRIGUES DE; CAMPOS, KAROLINE RODRIGUES; SACCHI, CLAUDIO TAVARES; TIBA-CASAS, MONIQUE RIBEIRO; CAMARGO, CARLOS HENRIQUE. A clinical Pseudomonas chlororaphis isolate harboring a new blaVIM-2 borne integron, In2088, isolated from bloodstream infection in a newborn patient. INFECTION GENETICS AND EVOLUTION, v. 96, DEC 2021. (19/21361-8, 17/50333-7, 18/21192-9, 18/21193-5)

MATSUMOTO, PATRICIA SAYURI SILVESTRE; TANIGUCHI, HELENA HILOMI; PEREIRA, VIRGINIA BODELA RICHINI; HIRAMOTO, ROBERTO MITSUYOSHI; RAMPAZZI, KARLA LETICIA SEVIERO; BARBOSA, JOSE EDUARDO DE RAEFFRAY; NETO, ROLDAO ANTONIO PUCI; CAMPRIGHER, VALERIA MEDINA; CORTEZ, LUIZ RICARDO PAES DE BARROS; RAHAMAN, KHAN RUBAYET; et al. Efficacies of insecticide dog collars against visceral leishmaniasis in low and high-income areas and the effects for non-collared neighbor dogs. Acta Tropica, v. 235, p. 9-pg., 2022-08-19. (21/08630-0, 17/50333-7, 21/03872-5, 18/25889-4, 19/22246-8)

RODRIGUES, D. K. B.; BONFIETTI, L. X.; GARCIA, R. A.; ARAUJO, M. R.; RODRIGUES, J. S.; GIMENES, V. M. F.; MELHEM, M. S. C.. Antifungal susceptibility profile of Candida clinical isolates from 22 hospitals of São Paulo State, Brazil. Brazilian Journal of Medical and Biological Research, v. 54, n. 9, 2021. (17/50333-7, 18/18996-9)

LIMA, MARTA LOPES; AMARAL, MAIARA; TREIGER BORBOREMA, SAMANTA ETEL; TEMPONE, ANDRE GUSTAVO. Evaluation of antileishmanial potential of the antidepressant escitalopram in Leishmania infantum. Journal of Pharmaceutical and Biomedical Analysis, v. 209, FEB 5 2022. (19/10434-4, 17/50333-7)

LIMA, MARTA LOPES; ABENGOZAR, MARIA A.; TORRES-SANTOS, EDUARDO CAIO; BORBOREMA, SAMANTA ETEL TREIGER; GODZIEN, JOANNA; LOPEZ-GONZALVEZD, ANGELES; BARBAS, CORAL; RIVAS, LUIS; TEMPONE, ANDRE GUSTAVO. Energy metabolism as a target for cyclobenzaprine: A drug candidate against Visceral Leishmaniasis. BIOORGANIC CHEMISTRY, v. 127, p. 11-pg., 2022-07-13. (17/50333-7, 19/10434-4, 21/04464-8)

AMARAL, MAIARA; VARELA, MARINA T.; KANT, RAVI; CHRISTODOULIDES, MYRON; FERNANDES, JOAO PAULO S.; TEMPONE, ANDRE G.. Synthetic Analogues of Gibbilimbol B Induce Bioenergetic Damage and Calcium Imbalance in Trypanosoma cruzi. LIFE-BASEL, v. 13, n. 3, p. 17-pg., 2023-03-01. (21/04464-8, 18/26655-7, 17/50333-7, 18/03918-2, 19/24028-8, 18/25128-3)

DE ANDRADE, TANIA SUELI; CAMARGO, CARLOS HENRIQUE; CAMPOS, KAROLINE RODRIGUES; REIS, ALEX DOMINGOS; SANTOS, MARLON BENEDITO DO NASCIMENTO; ZANELATTO, VANESSA NIERI; TAKAGI, ELIZABETH HARUMMYY; SACCHI, CLAUDIO TAVARES. Whole genome sequencing of Bacillus anthracis isolated from animal in the 1960s, Brazil, belonging to the South America subclade. COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES, v. 100, p. 6-pg., 2023-09-01. (18/21192-9, 17/50333-7)

CAMARGO, CARLOS HENRIQUE; YAMADA, AMANDA YAEKO; DE SOUZA, ANDREIA RODRIGUES; CUNHA, MARCOS PAULO VIEIRA; FERRARO, PEDRO SMITH PEREIRA; SACCHI, CLAUDIO TAVARES; DOS SANTOS, MARLON BENEDITO; CAMPOS, KAROLINE RODRIGUES; TIBA-CASAS, MONIQUE RIBEIRO; FREIRE, MARISTELA PINHEIRO; et al. Genomic analysis and antimicrobial activity of β-lactam/β-lactamase inhibitors and other agents against KPC-producing Klebsiella pneumoniae clinical isolates from Brazilian hospitals. SCIENTIFIC REPORTS, v. 13, n. 1, p. 9-pg., 2023-09-05. (18/21192-9, 17/50333-7, 20/06157-2)

ROMANELLI, MAIARA M.; AMARAL, MAIARA; THEVENARD, FERNANDA; CRUZ, LUCAS M. SANTA; REGASINI, LUIS O.; MIGOTTO, ALVARO E.; LAGO, JOAO HENRIQUE G.; TEMPONE, ANDRE G.. Mitochondrial Imbalance of Trypanosoma cruzi Induced by the Marine Alkaloid 6-Bromo-2 '-de-N-Methylaplysinopsin. ACS OMEGA, v. 7, n. 32, p. 10-pg., 2022-08-04. (17/50333-7, 21/04464-8, 21/02789-7)