Genes Differentially Expressed During Reversion Skeletal Muscle Atrophy

• Grant number: 18/01308-2
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2018
• End date: August 31, 2021
• Field of knowledge: Biological Sciences - Biochemistry - Molecular Biology
• Principal Investigator: Marcelo Damário Gomes
• Grantee: Marcelo Damário Gomes
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Muscle wasting or atrophy is a condition associated with major human systemic diseases including, diabetes, cancer, and kidney failure, among others. There is accumulating evidence from comparison of transcriptional profiles that a common set of genes, termed atrogenes, are modulated in atrophying muscles. However, the transcriptional changes that trigger reversion or attenuation of muscle atrophy have not been characterized at the molecular level. To identify key factors involved in the recovery of skeletal muscle mass, we will use cDNA microarrays and phosphorylation profiles of kinases (protein array) to investigate genes differentially expressed during the atrophy reversion of the androgen-sensitive levator ani muscle (LA), in the well-established model of castration and testosterone replacement. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

YSHII, LIDIA M.; MANFIOLLI, ADRIANA O.; DENADAI-SOUZA, ALEXANDRE; KINOSHITA, PAULA F.; GOMES, MARCELO D.; SCAVONE, CRISTOFORO. Tumor necrosis factor receptor-associated factor 6 interaction with alpha-synuclein enhances cell death through the Nuclear Factor-kB pathway. IBRO REPORTS, v. 9, p. 218-223, DEC 2020. (12/07784-4, 11/10303-5, 14/24951-7, 09/12375-3, 18/01308-2, 16/07427-8, 19/10044-1, 18/14289-6, 13/22196-4)

SPAGNOL, VALENTINE; OLIVEIRA, CAIO A. B.; RANDLE, SUZANNE J.; PASSOS, PATRICIA M. S.; CORREIA, CAMILA R. S. T. B.; SIMAROLI, NATALIA B.; OLIVEIRA, JOICE S.; MEVISSEN, TYCHO E. T.; MEDEIROS, ANA CARLA; GOMES, MARCELO D.; et al. The E3 ubiquitin ligase SCF(Fbxo7) mediates proteasomal degradation of UXT isoform 2 (UXT-V2) to inhibit the NF-kappa B signaling pathway. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, v. 1865, n. 1, JAN 2021. (16/25798-3, 16/21310-6, 16/00792-2, 17/22153-4, 17/07879-9, 18/09204-1, 19/03943-0, 18/01308-2)

GACHET-CASTRO, CAMILA; FREITAS-CASTRO, FELIPE; GONZALES-CORDOVA, RAUL ALEXANDER; DA FONSECA, CAROL KOBORI; GOMES, MARCELO DAMARIO; ISHIKAWA-ANKERHOLD, HELLEN CRISTINA; BAQUI, MUNIRA MUHAMMAD ABDEL. Modulation of the Host Nuclear Compartment by Trypanosoma cruzi Uncovers Effects on Host Transcription and Splicing Machinery. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, v. 11, OCT 19 2021. (18/03677-5, 10/19547-1, 18/01308-2)