Development of devices based on cassava starch for controlled release of bioactives from amazonian fungi

• Grant number: 20/08212-0
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2021
• End date: August 31, 2023
• Field of knowledge: Engineering - Chemical Engineering - Chemical Technology
• Agreement: FAPEAM
• Principal Investigator: Mariana Agostini de Moraes
• Grantee: Mariana Agostini de Moraes
• Host Institution: Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF). Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Diadema , SP, Brazil
• Associated researchers: Juliane Viganó ; Marne Carvalho de Vasconcellos ; Pedro Henrique Campelo Felix ; Priscilla Carvalho Veggi

Abstract

Drugs administered orally or subcutaneously result in a high concentration of the drug, but only a small amount reaches the site of interest, resulting in low efficiency, generating several side effects and requiring the patient to take the medication at pre-established intervals. In this context, the controlled release of drugs is of great interest, as it allows the administration of the drug in the correct place, gradually releasing small amounts of drug over long periods of time, optimizing the required drug dose, showing greater efficacy and reducing side effects. In this project, it is proposed the development of starch membranes extracted from cassava that can act as devices for controlled release of drugs with healing and anticancer effects, which are produced by fungi isolated from plant species in the Amazon region. The experimental methodology of this project is divided into four stages that will be performed by researchers from the State of Amazonas (AM) and São Paulo (SP): (i) obtaining fungal metabolite broths, (ii) concentration by the application of extraction with pressurized liquids, (iii) incorporation of the extract in cassava starch membranes and (iv) verification of the effectiveness of the devices developed in relation to the healing and anti-cancer action. It is expected with this project to develop platforms to act as controlled release devices, with possible healing and anti-cancer action, using compounds extracted from Amazonian biodiversity, promoting the transfer of knowledge and technology between the research groups of both States. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE BRITO, VIVIAN P.; DE SOUZA RIBEIRO, MAURICIO M.; VIGANO, JULIANE; DE MORAES, MARIANA A.; VEGGI, PRISCILLA C.. Silk Fibroin Hydrogels Incorporated with the Antioxidant Extract of Stryphnodendron adstringens Bark. POLYMERS, v. 14, n. 22, p. 15-pg., 2022-11-01. (20/15774-5, 20/08212-0, 20/07575-2)

FALCAO, LUCAS DE SOUZA; COELHO, DEBORAH BENTO; VEGGI, PRISCILLA CARVALHO; CAMPELO, PEDRO HENRIQUE; ALBUQUERQUE, PATRICIA MELCHIONNA; DE MORAES, MARIANA AGOSTINI. Starch as a Matrix for Incorporation and Release of Bioactive Compounds: Fundamentals and Applications. POLYMERS, v. 14, n. 12, p. 16-pg., 2022-06-01. (20/08212-0, 20/07575-2)

DE LIMA OLIVEIRA, ISABELLA; DE SOUZA FALCAO, LUCAS; CAMPELO, PEDRO HENRIQUE; DE MORAES, MARIANA AGOSTINI. Thermal modification and oxidation of cassava starch to produce biodegradable films. RS ADVANCE, v. N/A, p. 6-pg., 2023-01-11. (20/08212-0)