Nanostructured materials based on alkylated nucleosides with anticancer properties incorporated in Langmuir and Langmuir-Blodgett films of lipids and luminescent probes

• Grant number: 22/13938-6
• Support Opportunities: Regular Research Grants
• Start date: March 01, 2023
• End date: February 28, 2025
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
• Agreement: Universidad de Antioquia (UdeA)
• Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
• Principal Investigator: Luciano Caseli
• Grantee: Luciano Caseli
• Principal researcher abroad: Cristiano Giordani
• Institution abroad: Universidad de Antioquia (UdeA), Colombia
• Host Institution: Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF). Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Diadema , SP, Brazil
• Associated researchers: Celso Molina
• Associated research grant: 22/03736-7 - Nanostructured interfaces for the investigation of bioactive substances in cell membrane models and for the construction of optoelectronic devices, AP.R

Abstract

We propose the Brazilian team deliver a seminar/short course about nanotechnology at the University of Antioquia. We believe that this would impact in the following terms: i) Stimulate future exchange students from Colombia to go to Brazil in future partnership programs; ii) Establish closer collaboration with other Prof. Giordani's collaborators at Antioquia University; and iii) Discuss the ongoing results and establish new experiments and/or a project involving ongoing collaboration. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MOREIRA, FELIPE ALMEIDA; ESCOBAR, JHON FERNANDO BERRIO; GIORDANI, CRISTIANO; CASELI, LUCIANO. Exploring the physicochemical properties of the integration of Tristearoyl uridine in Langmuir monolayers: An approach to cell membrane modeling for prodrugs. Biophysical Chemistry, v. 310, p. 9-pg., 2024-05-09. (23/00850-6, 22/03736-7, 22/13938-6)

MOREIRA, FELIPE ALMEIDA; ESCOBAR, JHON FERNANDO BERRIO; GIORDANI, CRISTIANO; CASELI, LUCIANO. Langmuir monolayers provide an effective strategy for studying molecular recognition of nucleobases using alkylated nucleotides. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 244, p. 8-pg., 2024-08-08. (23/00850-6, 22/03736-7, 22/13938-6)