| Grant number: | 08/57721-3 |
| Support Opportunities: | Research Projects - Thematic Grants |
| Start date: | March 01, 2009 |
| End date: | February 28, 2015 |
| Field of knowledge: | Biological Sciences - Biochemistry - Metabolism and Bioenergetics |
| Agreement: | CNPq - INCTs |
| Principal Investigator: | Ohara Augusto |
| Grantee: | Ohara Augusto |
| Host Institution: | Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
| Associated scholarship(s): | 13/10780-3 - Oxidation and aggregation of human superoxide dismutase 1 resulting from its bicarbonate-dependent peroxidase activity, BP.PD |
Abstract
The study of redox processes has high potential to elucidate integrative mechanisms, due to the ubiquity and strength of their effects. Many studies involve the role of redox mechanisms in diseases. However, the complexity of this field has increased concerning structures, structure-function relations, methods, molecular and sub-cellular pathology of redox-regulated proteins, genomics, proteomics and metabolomics of oxidative stress. Thus, a multidisciplinary approach has become essential for meaningful advances in the field. Also, emerging groups have difficulty to address relevant points and sharpen educational skills. The main purpose of our Redoxome Network is to foster integrative collaborations, promote sustained development and assist emerging groups. Our goal is to perform studies that allow the design and assessment of novel antioxidant strategies with clinical applicability. We will address issues relevant toward overcoming Iimitations in knowledge of redox processes, as follows: 1) ROS generation and control in biological systems; 2) chemical reactivity of reactive oxygen species (ROS) in biological environments and consequent changes in structure and function of biomolecules; 3) Mechanisms and networks involved in redox signaling processes relevant to human disease; 4) diagnostic and therapeutic applications of redox processes. These strategies will enable, on a national basis, a concerted effort to attack key questions bridging meaningful gaps in the field. Our efforts will foster integration of multiple disciplines and institutions in our country and result in advances with educational, scientific, environmental and socioeconomic impact. (AU)
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