National Institute of Obesity and Diabetes

• Grant number: 08/57952-5
• Support Opportunities: Research Projects - Thematic Grants
• Start date: November 01, 2009
• End date: December 31, 2016
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Agreement: CNPq - INCTs
• Principal Investigator: Mario Jose Abdalla Saad
• Grantee: Mario Jose Abdalla Saad
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated scholarship(s): 11/02806-7 - Characterization of the hypothalamic AMPK/mTOR in cancer-induced anorexia, BP.DR; 11/04116-8 - Evaluation of the TLR2 function in breast cancer development in obesity animal models, BP.MS; 10/17944-3 - CARACTERIZATION OF IRS1/Akt/mTOR PATHWAY ON TUMOR XENOGRAFTS OF MICE FED HYPERPROTEIN DIET, BP.DR; 10/14847-7 - The role of dsRNA-dependent protein kinase (PKR) on colon tumor development in obese mice, BP.DR; 09/16357-0 - Characterization of IR, IRS-1 and Akt s-nitrosation in the skeletal muscle of experimental model of aging, BP.PD

Abstract

Obesity is prevalent in developed and developing countries, and is now affecting children worldwide. The epidemic reflects behavioral changes that include the reduction of physical activity, increased intake of fat-rich diets and food with higher caloric content. However, many people become obese due to a genetic predisposition to rapid weight gain, when exposed to unfavorable environmental cues. As expected, this epidemic also increases obesity serious complications Iike type 2 diabetes, cardiac diseases, arterial hypertension, cerebral vascular disease, arthritis, sleep apnea, non-alcoholic steatohepatitis, several forms of cancer, depression and premature death. The impact of the complications of this globesity has already taken over health services and the impact in public health is already bigger than the complications from tobacco. Recent data, from different countries as well as from Brazil have shown that the obesity epidemic induced an impressive increase in the prevalence of diabetes on the population. Diabetes mellitus (DM) is defined as a chronic hyperglycemia syndrome resultant of the lack of insulin production and/or the resistance to this hormones action. The DM classification includes: a) DM type 1; b) type 2 DM; c) DM secondary or associated with other diseases and d) gestational DM. Around 90% of the DM cases are of the type 2 and it occurrence in the world adult population (including Brazil) is around 8-10%. The settling of this type of diabetes is resultant of insulin followed by the pancreatic beta cells incapacity to secrete adequate amounts of the hormone to compensate the hyperglycemia. The DM, especially type 2 DM, usually comes accompanied by obesity, dyslipidemia and hypertension that at medium and long term cause cardiovascular dysfunction, nephropathy, retinopathy and neuropathy among others. Therefore, with the epidemiologic importance that obesity and diabetes reached in Brazil, and with the assistance of a highly qualified group of researchers widely spread throughout the country, we present a proposal for the National Institute of Science and Technology for the generation and dissemination of knowledge in the areas of obesity and diabetes. The institute program foresees the union of research lines and researchers from the following locations: Instituto de Biologia e Faculdade de Ciências Médicas (UNICAMP); Instituto de Ciências Biomédicas (USP); Faculdade de Saúde Pública (UNIFESP); Departamento de Medicina (UFPR); Departamento de Clínica Médica (UFC); Departamento de Nutrição (UFMT). The institute has four missions: 1- research; 2-human resources formation; 3- knowledge transferring to the society and 4a- knowledge transferring to the government with active participation in public policies regarding obesity and diabetes; 4b-knowledge transferring to the private sector or the government in the form of patents with diagnostic and therapeutic purposes... (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MORI, MATEUS P.; COSTA, RUTE A. P.; SOLTYS, DANIELA T.; FREIRE, THIAGO DE S.; ROSSATO, FRANCO A.; AMIGO, IGNACIO; KOWALTOWSKI, ALICIA J.; VERCESI, ANBAL E.; DE SOUZA-PINTO, NADJA C.. Lack of XPC leads to a shift between respiratory complexes I and II but sensitizes cells to mitochondrial stress. SCIENTIFIC REPORTS, v. 7, MAR 13 2017. (12/11889-6, 08/57952-5, 10/51906-1, 11/50400-0, 08/57721-3, 06/59786-0, 13/07937-8)

FERREIRA, SANDRA MARA; SANTOS, GUSTAVO JORGE; REZENDE, LUIZ F.; GONCALVES, LUCIANA MATEUS; SANTOS-SILVA, JUNIA CAROLINA; BIGARELLA, CAROLINA LOUZAO; CARNEIRO, EVERARDO MAGALHAES; OLLALA SAAD, SARA TERESINHA; BOSCHERO, ANTONIO CARLOS; BARBOSA-SAMPAIO, HELENA CRISTINA. ARHGAP21 prevents abnormal insulin release through actin rearrangement in pancreatic islets from neonatal mice. Life Sciences, v. 127, p. 53-58, APR 15 2015. (08/57952-5, 11/12050-7)