Investigation of genetic and epigenetic markers: a translational approach for schizophrenia treatment

• Grant number: 10/08968-6
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2010
• End date: January 31, 2013
• Field of knowledge: Health Sciences - Medicine - Psychiatry
• Principal Investigator: Síntia Iole Nogueira Belangero
• Grantee: Síntia Iole Nogueira Belangero
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated researchers: Ary Gadelha de Alencar Araripe Neto ; Denise Maria Christofolini ; Deyvis Macarof Loureiro Vasconcelos Rocha ; Fernanda Teixeira da Silva Bellucco ; Helio Elkis ; Jaime Eduardo Cecilio Hallak ; Jair de Jesus Mari ; Maria Isabel de Souza Aranha Melaragno ; Mariana Bendlin Calzavara ; Marilia de Arruda Cardoso Smith ; Patrícia Natália Silva Moretti ; Rodrigo Affonseca Bressan ; Vanessa Costhek Abílio

Scientific publications

(22)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

NOTO, MARIANE NUNES; MAES, MICHAEL; VARGAS NUNES, SANDRA ODEBRECHT; OTA, VANESSA KIYOMI; ROSSANEIS, ANA C.; VERRI, JR., WALDICEU A.; CORDEIRO, QUIRINO; BELANGERO, SINTIA IOLE; GADELHA, ARY; BRESSAN, RODRIGO AFFONSECA; et al. Activation of the immune-inflammatory response system and the compensatory immune-regulatory system in antipsychotic naive first episode psychosis. European Neuropsychopharmacology, v. 29, n. 3, p. 416-431, MAR 2019. (14/07280-1, 11/50740-5, 10/08968-6)

DE JONG, SIMONE; ABDALLA DINIZ, MATEUS JOSE; SALOMA, ANDIARA; GADELHA, ARY; SANTORO, MARCOS L.; OTA, VANESSA K.; NOTO, CRISTIANO; CURTIS, CHARLESG; NEWHOUSE, STEPHEN J.; PATEL, HAMEL; et al. Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder. COMMUNICATIONS BIOLOGY, v. 1, 2018. (14/50830-2, 10/08968-6)

GOUVEA, E. S.; OTA, V. K.; NOTO, C.; SANTORO, M. L.; SPINDOLA, L. M.; MORETTI, P. N.; CARVALHO, C. M.; XAVIER, G.; RIOS, A. C.; SATO, J. R.; et al. Gene expression alterations related to mania and psychosis in peripheral blood of patients with a first episode of psychosis. TRANSLATIONAL PSYCHIATRY, v. 6, OCT 4 2016. (11/50740-5, 14/50830-2, 12/12686-1, 13/10498-6, 10/08968-6, 14/07280-1)

NOTO, CRISTIANO; OTA, VANESSA KIYOMI; SANTORO, MARCOS LEITE; GOUVEA, EDUARDO SAUERBRONN; SILVA, PATRICIA NATALIA; SPINDOLA, LETICIA MARIA; CORDEIRO, QUIRINO; BRESSAN, RODRIGO AFFONSECA; GADELHA, ARY; BRIETZKE, ELISA; et al. Depression, Cytokine, and Cytokine by Treatment Interactions Modulate Gene Expression in Antipsychotic Naive First Episode Psychosis. Molecular Neurobiology, v. 53, n. 8, p. 5701-5709, OCT 2016. (10/08968-6, 11/50740-5, 13/10498-6, 10/19176-3)

EDUARDO S. GOUVÊA; AIRTON F. SANTOS FILHO; VANESSA K. OTA; VINICIUS MRAD; ARY GADELHA; RODRIGO A. BRESSAN; QUIRINO CORDEIRO; SINTIA I. BELANGERO. The role of the CNR1 gene in schizophrenia: a systematic review including unpublished data. Revista Brasileira de Psiquiatria, v. 39, n. 2, p. 160-171, 2017-01-12. (11/00030-1, 11/50740-5, 10/08968-6)

SANTORO, MARCOS LEITE; GADELHA, ARY; OTA, VANESSA K.; CUNHA, GRACCIELLE R.; ASEVEDO, ELSON; NOTO, CRISTIANO S.; SPINDOLA, LETICIA M.; PAN, PEDRO M.; TALARICO, FERNANDA; MANSUR, RODRIGO B.; et al. Gene expression analysis in blood of ultra-high risk subjects compared to first-episode of psychosis patients and controls. WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, v. 16, n. 6, p. 441-446, 2015. (10/08968-6, 12/12686-1, 11/50740-5, 10/19176-3)

DIANA, MARIANA C.; SANTORO, MARCOS L.; XAVIER, GABRIELA; SANTOS, CAMILA MAURICIO; SPINDOLA, LETICIA N.; MORETTI, PATRICIA N.; OTA, VANESSA K.; BRESSAN, RODRIGO A.; ABILIO, VANESSA C.; BELANGERO, SINTIA I.. Low expression of Gria1 and Grin1 glutamate receptors in the nucleus accumbens of Spontaneously Hypertensive Rats (SHR). PSYCHIATRY RESEARCH, v. 229, n. 3, p. 690-694, OCT 30 2015. (10/08968-6, 10/13859-1, 11/50740-5)

SANTORO, MARCOS LEITE; OTA, VANESSA KIYOMI; STILHANO, ROBERTA SESSA; SILVA, PATRICIA NATALIA; SANTOS, CAMILA MAURICIO; DIANA, MARIANA CEPOLLARO; GADELHA, ARY; BRESSAN, RODRIGO AFFONSECA; MELARAGNO, MARIA ISABEL; HAN, SANG WON; et al. Effect of antipsychotic drugs on gene expression in the prefrontal cortex and nucleus accumbens in the spontaneously hypertensive rat (SHR). SCHIZOPHRENIA RESEARCH, v. 157, n. 1-3, p. 163-168, AUG 2014. (10/08968-6, 10/13859-1)

OTA, VANESSA KIYOMI; NOTO, CRISTIANO; GADELHA, ARY; SANTORO, MARCOS LEITE; SPINDOLA, LETICIA MARIA; GOUVEA, EDUARDO SAUERBRONN; STILHANO, ROBERTA SESSA; ORTIZ, BRUNO BERTOLUCCI; SILVA, PATRICIA NATALIA; SATO, JOAO RICARDO; et al. Changes in gene expression and methylation in the blood of patients with first-episode psychosis. SCHIZOPHRENIA RESEARCH, v. 159, n. 2-3, p. 358-364, NOV 2014. (10/08968-6, 11/50740-5, 13/10498-6, 10/19176-3)

OTA, VANESSA KIYOMI; NOTO, CRISTIANO; GADELHA, ARY; SANTORO, MARCOS LEITE; ORTIZ, BRUNO BERTOLUCCI; ANDRADE, ELVIS HENRIQUE; TASSO, BRAZILIO CARVALHO; NERY SPINDOLA, LETICIA MARIA; SILVA, PATRICIA NATALIA; ABILIO, VANESSA COSTHEK; et al. Evaluation of neurotransmitter receptor gene expression identifies GABA receptor changes: A follow-up study in antipsychotic-naive patients with first-episode psychosis. JOURNAL OF PSYCHIATRIC RESEARCH, v. 56, p. 130-136, SEP 2014. (10/08968-6, 11/50740-5, 13/10498-6, 10/19176-3)

OTA, VANESSA KIYOMI; MORETTI, PATRICIA NATALIA; SANTORO, MARCOS LEITE; TALARICO, FERNANDA; SPINDOLA, LETICIA MARIA; XAVIER, GABRIELA; CARVALHO, CAROLINA MUNIZ; MARQUES, DIOGO FERRI; COSTA, GIOVANY OLIVEIRA; PELLEGRINO, RENATA; et al. Gene expression over the course of schizophrenia: from clinical high-risk for psychosis to chronic stages. NPJ SCHIZOPHRENIA, v. 5, MAR 28 2019. (14/50830-2, 11/00030-1, 14/07280-1, 10/08968-6, 17/25016-8, 16/04983-7, 11/50740-5)

MAURYA, PAWAN KUMAR; RIZZO, LUCAS BORTOLOTTO; XAVIER, GABRIELA; TEMPAKU, PRISCILA FARIAS; OTA, VANESSA KIYOMI; SANTORO, MARCOS L.; SPINDOLA, LETICIA M.; MORETTI, PATRICIA S.; MAZZOTTI, DIEGO R.; GADELHA, ARY; et al. Leukocyte telomere length variation in different stages of schizophrenia. JOURNAL OF PSYCHIATRIC RESEARCH, v. 96, p. 218-223, JAN 2018. (10/08968-6, 14/07280-1)

KAGAN, SIMAO; COGO-MOREIRA, HUGO; BARBOSA, MATHEUS GHOSSAIN; CAVALCANTE, DANIEL; SHINJI, ANDRE; NOTO, MARIANE; HAGUIARA, BERNARDO; CORDEIRO, QUIRINO; BELANGEIRO, SINTIA; BRESSAN, RODRIGO A.; et al. Longitudinal invariance of the positive and negative syndrome scale negative dimension in antipsychotic naive first-episode schizophrenia. EARLY INTERVENTION IN PSYCHIATRY, JUL 2021. (14/07280-1, 17/25016-8, 10/08968-6)

TALARICO, FERNANDA; SANTORO, MARCOS; OTA, VANESSA K.; GADELHA, ARY; PELLEGRINO, RENATA; HAKONARSON, HAKON; BRESSAN, RODRIGO; MARI, JAIR J.; BELANGERO, SINTIA. Implications of an admixed Brazilian population in schizophrenia polygenic risk score. SCHIZOPHRENIA RESEARCH, v. 204, p. 404-406, FEB 2019. (14/07280-1, 10/08968-6, 16/04983-7, 11/50740-5, 17/20059-0)

SANTORO, MARCOS LEITE; OTA, VANESSA; DE JONG, SIMONE; NOTO, CRISTIANO; SPINDOLA, LETICIA M.; TALARICO, FERNANDA; GOUYEA, EDUARDO; LEE, SANG HYUCK; MORETTI, PATRICIA; CURTIS, CHARLES; et al. Polygenic risk score analyses of symptoms and treatment response in an antipsychotic-naive first episode of psychosis cohort. TRANSLATIONAL PSYCHIATRY, v. 8, AUG 31 2018. (14/50830-2, 14/07280-1, 14/22223-4, 12/12686-1, 10/08968-6, 16/13737-0, 16/04983-7, 11/50740-5)

BELANGERO, SINTIA IOLE; OTA, VANESSA KIYOMI; GADELHA, ARY; BERBERIAN, ARTHUR ALMEIDA; DE ASSUNCAO-LEME, IDAIANE BATISTA; NOTO, CRISTIANO; CHRISTOFOLINI, DENISE MARIA; BELLUCCO, FERNANDA TEIXEIRA; SANTORO, MARCOS LEITE; MAZZOTTI, DIEGO ROBLES; et al. DGCR2 influences cortical thickness through a mechanism independent of schizophrenia pathogenesis. PSYCHIATRY RESEARCH, v. 274, p. 391-394, APR 2019. (16/04983-7, 17/25016-8, 10/08968-6, 14/07280-1, 11/00030-1)

NOTO, CRISTIANO; OTA, VANESSA KIYOMI; GADELHA, ARY; NOTO, MARIANE NUNES; BARBOSA, DECIO SABBATINI; BONIFACIO, KAMILA LANDUCCI; NUNES, SANDRA ODEBRECHT; CORDEIRO, QUIRINO; BELANGERO, SINTIA IOLE; BRESSAN, RODRIGO AFFONSECA; et al. Oxidative stress in drug naive first episode psychosis and antioxidant effects of risperidone. JOURNAL OF PSYCHIATRIC RESEARCH, v. 68, p. 210-216, SEP 2015. (10/08968-6, 11/50740-5, 13/10498-6, 10/19176-3)

NOTO, CRISTIANO; OTA, VANESSA KIYOMI; SANTORO, MARCOS LEITE; ORTIZ, BRUNO B.; RIZZO, LUCAS B.; HIGUCHI, CINTHIA HIROKO; CORDEIRO, QUIRINO; BELANGERO, SINTIA IOLE; BRESSAN, RODRIGO AFFONSECA; GADELHA, ARY; et al. Effects of depression on the cytokine profile in drug naive first-episode psychosis. SCHIZOPHRENIA RESEARCH, v. 164, n. 1-3, p. 53-58, MAY 2015. (10/08968-6, 11/50740-5, 13/10498-6, 10/19176-3)

OTA, VANESSA KIYOMI; NOTO, CRISTIANO; GADELHA, ARY; SANTORO, MARCOS LEITE; SILVA, PATRICIA NATALIA; MELARAGNO, MARIA ISABEL; CARDOSO SMITH, MARILIA DE ARRUDA; CORDEIRO, QUIRINO; BRESSAN, RODRIGO AFFONSECA; BELANGERO, SINTIA IOLE. Neurotransmitter receptor and regulatory gene expression in peripheral blood of Brazilian drug-naive first-episode psychosis patients before and after antipsychotic treatment. PSYCHIATRY RESEARCH, v. 210, n. 3, p. 1290-1292, DEC 30 2013. (10/08968-6, 11/50740-5)

TRUBETSKOY, VASSILY; PARDINAS, ANTONIO F.; QI, TING; PANAGIOTAROPOULOU, GEORGIA; AWASTHI, SWAPNIL; BIGDELI, TIM B.; BRYOIS, JULIEN; CHEN, CHIA-YEN; DENNISON, CHARLOTTE A.; HALL, LYNSEY S.; et al. Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Nature, v. 604, n. 7906, p. 24-pg., 2022-04-08. (14/07280-1, 10/08968-6, 11/50740-5)

MARQUES, DIOGO FERRI; OTA, VANESSA KIYOMI; SANTORO, MARCOS LEITE; TALARICO, FERNANDA; COSTA, GIOVANY OLIVEIRA; SPINDOLA, LETICIA MARIA; COGO-MOREIRA, HUGO; CARVALHO, CAROLINA MUNIZ; XAVIER, GABRIELA; CAVALCANTE, DANIEL AZEVEDO; et al. LINE-1 hypomethylation is associated with poor risperidone response in a first episode of psychosis cohort. Epigenomics, v. 12, n. 12, APR 2020. (16/04983-7, 11/50740-5, 16/02246-5, 17/25016-8, 10/08968-6, 14/07280-1)

ASSUNCAO-LEME, IDAIANE BATISTA; ZUGMAN, ANDRE; DE MOURA, LUCIANA MONTEIRO; SATO, JOAO RICARDO; HIGUCHI, CINTHIA; ORTIZ, BRUNO BERTOLUCCI; NOTO, CRISTIANO; OTA, VANESSA KIYOMI; BELANGERO, SINTIA IOLE; BRESSAN, RODRIGO A.; et al. Is treatment-resistant schizophrenia associated with distinct neurobiological callosal connectivity abnormalities?. CNS SPECTRUMS, v. 26, n. 5, p. 545-549, OCT 2021. (14/07280-1, 10/08968-6)