Bone marrow microenvironment and PI3K pathway in resistance to chemotherapy of pediatric acute lymphoblastic leukemia

• Grant number: 08/10034-1
• Support Opportunities: Regular Research Grants
• Start date: April 01, 2009
• End date: June 30, 2011
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: José Andrés Yunes
• Grantee: José Andrés Yunes
• Host Institution: Centro Infantil de Investigações Hematológicas Dr Domingos A Boldrini (CIB). Campinas , SP, Brazil

Scientific publications

(10)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ZENATTI, PRISCILA P.; RIBEIRO, DANIEL; LI, WENQING; ZUURBIER, LINDA; SILVA, MILENE C.; PAGANIN, MADDALENA; TRITAPOE, JULIA; HIXON, JULIE A.; SILVEIRA, ANDRE B.; CARDOSO, BRUNO A.; et al. Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia. Nature Genetics, v. 43, n. 10, p. 932-U31, OCT 2011. (08/10034-1)

JOTTA‚ PY; GANAZZA‚ MA; SILVA‚ A.; VIANA‚ MB; DA SILVA‚ MJ; ZAMBALDI‚ LJG; BARATA‚ JT; BRANDALISE‚ SR; YUNES‚ JA. Negative prognostic impact of PTEN mutation in pediatric T-cell acute lymphoblastic leukemia. LEUKEMIA, v. 24, n. 1, p. 239-242, 2009. (08/10034-1)

MENDES, RUI D.; SARMENTO, LEONOR M.; CANTE-BARRETT, KIRSTEN; ZUURBIER, LINDA; BUIJS-GLADDINES, JESSICA G. C. A. M.; POVOA, VANDA; SMITS, WILLEM K.; ABECASIS, MIGUEL; YUNES, J. ANDRES; SONNEVELD, EDWIN; et al. PTEN microdeletions in T-cell acute lymphoblastic leukemia are caused by illegitimate RAG-mediated recombination events. Blood, v. 124, n. 4, p. 567-578, JUL 24 2014. (08/10034-1)

MANSUR, MARCELA BRAGA; HASSAN, ROCIO; BARBOSA, THAYANA C.; SPLENDORE, ALESSANDRA; JOTTA, PATRICIA Y.; YUNES, JOSE ANDRES; WIEMELS, JOSEPH L.; POMBO-DE-OLIVEIRA, MARIA S.. Impact of complex NOTCH1 mutations on survival in paediatric T-cell leukaemia. BMC CANCER, v. 12, JAN 6 2012. (08/10034-1)

MILANI, MATEUS; ALBERTONI LARANJEIRA, ANGELO BRUNELLI; DE VASCONCELLOS, JAIRA FERREIRA; BRANDALISE, SILVIA REGINA; NOWILL, ALEXANDRE EDUARDO; YUNES, JOSE ANDRES. Plasma Hsp90 Level as a Marker of Early Acute Lymphoblastic Leukemia Engraftment and Progression in Mice. PLoS One, v. 10, n. 6, JUN 11 2015. (12/12802-1, 08/10034-1)

FERNANDES, MONICA T.; GHEZZO, MARINELLA N.; SILVEIRA, ANDRE B.; KALATHUR, RAVI K.; POVOA, VANDA; RIBEIRO, ANA R.; BRANDALISE, SILVIA R.; DEJARDIN, EMMANUEL; ALVES, NUNO L.; GHYSDAEL, JACQUES; et al. Lymphotoxin-beta receptor in microenvironmental cells promotes the development of T-cell acute lymphoblastic leukaemia with cortical/mature immunophenotype. British Journal of Haematology, v. 171, n. 5, p. 736-751, DEC 2015. (12/12802-1, 08/10034-1)

SILVEIRA, ANDRE BORTOLINI; ALBERTONI LARANJEIRA, ANGELO BRUNELLI; LIBANIO RODRIGUES, GISELE OLINTO; LEAL, PAULO CESAR; CARDOSO, BRUNO ANTONIO; BARATA, JOAO TABORDA; YUNES, ROSENDO AUGUSTO; TONIN ZANCHIN, NILSON IVO; BRANDALISE, SILVIA REGINA; YUNES, JOSE ANDRES. PI3K inhibition synergizes with glucocorticoids but antagonizes with methotrexate in T-cell acute lymphoblastic leukemia. ONCOTARGET, v. 6, n. 15, p. 13105-13118, MAY 30 2015. (08/10034-1)

SILVA, ANA; LARANJEIRA, ANGELO B. A.; MARTINS, LEILA R.; CARDOSO, BRUNO A.; DEMENGEOT, JOCELYNE; ANDRES YUNES, J.; SEDDON, BENEDICT; BARATA, JOAO T.. IL-7 Contributes to the Progression of Human T-cell Acute Lymphoblastic Leukemias. Cancer Research, v. 71, n. 14, p. 4780-4789, JUL 15 2011. (08/10034-1)

LARANJEIRA, A. B. A.; DE VASCONCELLOS, J. F.; SODEK, L.; SPAGO, M. C.; FORNAZIM, M. C.; TONE, L. G.; BRANDALISE, S. R.; NOWILL, A. E.; YUNES, J. A.. IGFBP7 participates in the reciprocal interaction between acute lymphoblastic leukemia and BM stromal cells and in leukemia resistance to asparaginase. LEUKEMIA, v. 26, n. 5, p. 1001-1011, MAY 2012. (08/02106-2, 08/10034-1)

CANEVAROLO, RAFAEL RENATINO; DE SOUZA MELO, CAROLINA PEREIRA; CURY, NATHALIA MORENO; ARTICO, LEONARDO LUIZ; CORREA, JULIANA RONCHI; LAU, YANCA TONHASCA; MARIANO, SAMARA SOUSA; SUDALAGUNTA, PRANEETH REDDY; BRANDALISE, SILVIA REGINA; DE MATTOS ZERI, ANA CAROLINA; et al. Glutathione levels are associated with methotrexate resistance in acute lymphoblastic leukemia cell lines. FRONTIERS IN ONCOLOGY, v. 12, p. 18-pg., 2022-12-01. (12/11952-0, 14/08247-8, 08/10034-1, 09/04167-1, 17/02400-7, 17/03239-5)