| Grant number: | 11/17411-8 |
| Support Opportunities: | Regular Research Grants |
| Start date: | November 01, 2011 |
| End date: | October 31, 2013 |
| Field of knowledge: | Engineering - Biomedical Engineering - Medical Engineering |
| Principal Investigator: | Rondinelli Donizetti Herculano |
| Grantee: | Rondinelli Donizetti Herculano |
| Host Institution: | Faculdade de Ciências e Letras (FCL-ASSIS). Universidade Estadual Paulista (UNESP). Campus de Assis. Assis , SP, Brazil |
| City of the host institution: | Assis |
| Associated researchers: | Bruno de Camargo Drago |
Abstract
The controlled release of drugs can be efficient if a suitable encapsulation procedure is developed, which requires biocompatible materials to hold and release the drug. Natural rubber latex (NRL) has been proven excellent for its biocompatibility and ability to stimulate angiogenesis, cellular adhesion and the formation of extracellular matrix, promoting the replacement and regeneration of tissue. In this study, a natural rubber latex (NRL) membrane will be used to deliver drugs. For this purpose Metronidazole (MET), Ketoprofen, Diclofenacs (Sodium and Potassium) will be incorporated into the latex solution for in vitro drug delivery experiments. MET is a nitroimidazole anti-infective medication used mainly in the treatment of infections caused by susceptible organisms, particularly anaerobic bacteria and protozoa. Ketoprofen and Diclofenacs(Sodium and Potassium) are non-steroidal anti-inflammatory drugs (NSAIDs) taken to reduce inflammation and as an analgesic reducing pain. The solutions of latex and drugs will be polymerized at different temperatures, from -100 to 40 °C, in order to control the membrane morphology. The number, size and distribution of pores in NRL membranes vary depending on polymerization temperature, as well as its overall morphology. The rate release of drugs will be controlled varying the polymerization temperature of the latex matrix. For the study of the release of drugs, latex membranes will be placed in 200 mL of an aqueous solution, from which aliquots were collected during an interval ranging from 10 to 24,000 min. The drugs released into the solution will be monitored by measuring the UV-VIS spectrophotometer. These membranes will be characterized by Scanning Electron Microscopy (SEM), X-ray diffraction (XRD), Atomic Force Microscopy (AFM), Fourier transform infrared (FTIR) spectroscopy and mechanical resistance tests. (AU)
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PROCESSO DE OBTENÇÃO DE MEMBRANA POROSA DE LÁTEX NATURAL, MEMBRANA POROSA DE LÁTEX NATURAL E SEUS USOS PCT/BR2016/050337 - Universidade Estadual Paulista Júlio de Mesquita Filho (Unesp) . Eduardo Maffud Cilli; Rondinelli Donizetti Herculano; Matheus Carlos Romeiro Miranda - January 2016, 01