Advanced search
Start date
Betweenand

Autonomic, metabolic and inflammatory aspects of metabolic syndrome associated with obstructive sleep apnea: effect of hypocaloric diet and physical training

Grant number: 11/17533-6
Support type:Regular Research Grants
Duration: February 01, 2012 - January 31, 2014
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Ivani Credidio Trombetta
Grantee:Ivani Credidio Trombetta
Home Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Assoc. researchers:Ana Maria Fonseca Wanderley Braga ; Carlos Eduardo Negrão ; Glauce Lamoglie de Carvalho ; Maria Janieire de Nazaré Nunes Alves ; Maria Urbana Pinto Brandão Rondon

Abstract

Context. Metabolic syndrome (MetS) is strongly associated with obstructive sleep apnea (OSA). MetS and OSA cause sympathetic hyperactivation, which mechanisms are not completely known. Metabolic, inflammatory and baro/chemoreflex control alterations may could explain, at least in part, the sympathetic hyperactivation. Objectives. In this study we intend to investigate whether OSA has an additive effect on hemodynamic and autonomic control and on metabolic and inflammatory markers and if there is association between sympathetic nerve hyperactivity with metabolic and inflammatory markers. In addition, we will investigate the effect of hypocaloric diet associated with exercise training (D+ET) on the severity of OSA, on the hemodynamic and autonomic control and on the metabolic/inflammatory controlin these MetS patients. Design, participants and intervertions. Prospective randomized clinical trial, blind. The MetS patients (according ATP-III) will be divided into MetS+OSA and MetS-OSA and all will be randomized for interventions by D (decrease of 500 kcal/day) and ET (3x/week, 50-70% VO2peak) or control period for 4 months. A normal control group will be also enrolled in this study. Methods. We will evaluate: OSA (polysomnography - measurer blind), physical fitness (ergospirometry), baroreflex sensitivity (spontaneous fluctuations of BP and HR), peripheral chemoreflex control (inhalation of hypoxic gas mixture with 10%O2 and 90% N2 for 3 min) and central (hypercapnic inhalation of 7%CO2 and 93%O2 for 3 min), insulin resistance (HOMA and OGTT) leptin and adiponectin and inflammatory markers, sympathetic nerve activity (microneurography), muscle blood flow (plethysmography), blood pressure (oscillometric); heart rate (ECG), oxygen saturation (oximetry), end-tidal CO2 (capnography), respiratory rate (piezoeletric), pulmonary ventilation (pneumotachograph) and pulse wave velocity.Main outcome measures. Absolute change from pre to post D+ET on hemodynamic, autonomic, metabolic and inflammatory control in MetS patients. (AU)

Scientific publications (9)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CEPEDA, FELIPE X.; VIRMONDES, LESLIE; RODRIGUES, SARA; DUTRA-MARQUES, AKOTHIRENE C. B.; TOSCHI-DIAS, EDGAR; FERREIRA-CAMARGO, FERNANDA C.; HUSSID, MARIA FERNANDA; RONDON, MARIA URBANA P. B.; ALVES, MARIA JANIEIRE N. N.; TROMBETTA, IVANI C. Identifying the risk of obstructive sleep apnea in metabolic syndrome patients: Diagnostic accuracy of the Berlin Questionnaire. PLoS One, v. 14, n. 5 MAY 21 2019. Web of Science Citations: 0.
TOSCHI-DIAS, EDGAR; TROMBETTA, IVANI C.; SILVA, VALDO J. D.; MAKI-NUNES, CRISTIANE; CEPEDA, FELIPE X.; ALVES, MARIA JANIEIRE N. N.; CARVALHO, GLAUCE L.; DRAGER, LUCIANO F.; LORENZI-FILHO, GERALDO; NEGRAO, CARLOS E.; RONDON, MARIA URBANA P. B. Diet associated with exercise improves baroreflex control of sympathetic nerve activity in metabolic syndrome and sleep apnea patients. Sleep and Breathing, v. 23, n. 1, p. 143-151, MAR 2019. Web of Science Citations: 2.
LOPES-VICENTE, WANDA R. P.; RODRIGUES, SARA; CEPEDA, FELIPE X.; JORDAO, CAMILA PAIXAO; COSTA-HONG, VALERIA; DUTRA-MARQUES, AKOTHIRENE C. B.; CARVALHO, JEFFERSON C.; ALVES, MARIA JANIEIRE N. N.; BORTOLOTTO, LUIZ A.; TROMBETTA, IVANI C. Arterial stiffness and its association with clustering of metabolic syndrome risk factors. DIABETOLOGY & METABOLIC SYNDROME, v. 9, OCT 25 2017. Web of Science Citations: 8.
PEREZ, EDUARDO ARAUJO; FRANCO OLIVEIRA, LUIS VICENTE; FREITAS, JR., WILSON RODRIGUES; MALHEIROS, CARLOS ALBERTO; ILIAS, ELIAS JIRJOSS; SILVA, ANDERSON SOARES; URBANO, JESSICA JULIOTI; OLIVEIRA, PATRICIA CLEMENTE; CEPEDA, FELIPE X.; SAMPAIO, LUCIANA M. M.; TROMBETTA, IVANI C.; DELLE, HUMBERTO; GIANELLA NETO, DANIEL; NACIF, SERGIO ROBERTO; STIRBULOV, ROBERTO. Prevalence and severity of syndrome Z in women with metabolic syndrome on waiting list for bariatric surgery: a cross-sectional study. DIABETOLOGY & METABOLIC SYNDROME, v. 9, SEP 20 2017. Web of Science Citations: 0.
RODRIGUES, SARA; CEPEDA, FELIPE X.; TOSCHI-DIAS, EDGAR; DUTRA-MARQUES, AKOTHIRENE C. B.; CARVALHO, JEFFERSON C.; COSTA-HONG, VALERIA; ALVES, MARIA JANIEIRE N. N.; RONDON, MARIA URBANA P. B.; BORTOLOTTO, LUIZ A.; TROMBETTA, IVANI C. The role of increased glucose on neurovascular dysfunction in patients with the metabolic syndrome. JOURNAL OF CLINICAL HYPERTENSION, v. 19, n. 9, p. 840-847, SEP 2017. Web of Science Citations: 2.
MAKI-NUNES, CRISTIANE; TOSCHI-DIAS, EDGAR; CEPEDA, FELIPE X.; RONDON, MARIA URBANA P. B.; ALVES, MARIA-JANIEIRE N. N.; FRAGA, RAFFAEL F.; BRAGA, ANA MARIA F. W.; AGUILAR, ADRIANA M.; AMARO, ALINE C.; DRAGER, LUCIANO F.; LORENZI-FILHO, GERALDO; NEGRAO, CARLOS E.; TROMBETTA, IVANI C. Diet and exercise improve chemoreflex sensitivity in patients with metabolic syndrome and obstructive sleep apnea. OBESITY, v. 23, n. 8, p. 1582-1590, AUG 2015. Web of Science Citations: 11.
CEPEDA, FELIPE X.; TOSCHI-DIAS, EDGAR; MAKI-NUNES, CRISTIANE; RONDON, MARIA URBANA P. B.; ALVES, MARIA JANIEIRE N. N.; BRAGA, ANA MARIA F. W.; MARTINEZ, DANIEL G.; DRAGER, LUCIANO F.; LORENZI-FILHO, GERALDO; NEGRAO, CARLOS E.; TROMBETTA, IVANI C. Obstructive Sleep Apnea Impairs Postexercise Sympathovagal Balance in Patients with Metabolic Syndrome. Sleep, v. 38, n. 7, p. 1059-1066, JUL 1 2015. Web of Science Citations: 7.
TOSCHI-DIAS, EDGAR; TROMBETTA, IVANI C.; DIAS DA SILVA, VALDO J.; MAKI-NUNES, CRISTIANE; CEPEDA, FELIPE X.; ALVES, MARIA-JANIEIRE N. N.; DRAGER, LUCIANO F.; LORENZI-FILHO, GERALDO; NEGRAO, CARLOS E.; RONDON, MARIA URBANA P. B. Time delay of baroreflex control and oscillatory pattern of sympathetic activity in patients with metabolic syndrome and obstructive sleep apnea. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 304, n. 7, p. H1038-H1044, APR 2013. Web of Science Citations: 18.
TROMBETTA, IVANI C.; MAKI-NUNES, CRISTIANE; TOSCHI-DIAS, EDGAR; ALVES, MARIA-JANIEIRE N. N.; RONDON, MARIA URBANA P. B.; CEPEDA, FELIPE X.; DRAGER, LUCIANO F.; BRAGA, ANA MARIA F. W.; LORENZI-FILHO, GERALDO; NEGRAO, CARLOS E. Obstructive Sleep Apnea is Associated with Increased Chemoreflex Sensitivity in Patients with Metabolic Syndrome. Sleep, v. 36, n. 1, p. 41-49, JAN 1 2013. Web of Science Citations: 28.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.