Acute response of smokers' mucociliary clearance toward aerobic exercise

• Grant number: 11/21125-0
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2012
• End date: January 31, 2014
• Field of knowledge: Health Sciences - Physiotherapy and Occupational Therapy
• Principal Investigator: Ercy Mara Cipulo Ramos
• Grantee: Ercy Mara Cipulo Ramos
• Host Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil
• Associated researchers: Alessandra Choqueta de Toledo ; Dionei Ramos

Abstract

Mucociliary clearance is an important defense mechanism of the respiratory tract that is influenced by the external environment, such as exposure to smoke and execution of exercises. Objectives: To evaluate the behavior of acute response of smokers' mucociliary clearance and the autonomic modulation toward moderate and mild aerobic exercise, as well as investigate possible correlations between these variables. To verify the influence of the acute smoking and its association with exercise on response of smokers' mucociliary clearance and autonomic modulation. Methods: Smokers with normal lung function will be evaluated concerning the mucociliary clearance by saccharin transit time (STT) and autonomic nervous system activity by heart rate variability (HRV) in six stages: at rest and abstinence, at rest immediately after smoking, after moderate aerobic exercise on abstinence and immediately after smoking; after mild aerobic exercise on abstinence and immediately after smoking. For comparison of baseline and the effect of exercise, will be assessed a control group with similar characteristics and nonsmokers. This group will not be expoused to smoke. Statistical analysis: The Graphpad Prism statistical program will be used. The normal distribution of data will be assessed by Shapiro-Wilk and description of the results will be held as mean ± standart derivation, except for variables with non-normal distribution, with will be described as median (interquartile range 25-75). For intergroup analysis will be used, the unpaired t test or Mann-Withney test. For analysis of the moments will be used analysis of variance for repeated measures, ANOVA followed by Tukey test or the Friedman test followed by Dunn's test. Correlations will be evaluated using the Pearson or Sperman coefficients. The choice of tests will depend on the normal distribution of data. The level of significance will be p<0,05. (AU)