Abstract
Among the kinds of pain that affect people throughout their lives, muscle pain, induced by sustained isometric contraction is one of the most prevalent kinds of pain and has an important socio-economic impact. However, despite their clinical relevance, the molecular mechanisms involved in the development of muscle pain induced by sustained isometric contraction are unknown. This is mainly due to the absence of a more realistic experimental model that has a good degree of prediction of pharmacological control of pain. Studies in humans and animals have provided evidence that endogenous ATP, via activation of P2X3 and P2X2/3 receptors, may induce muscle pain. Therefore, the aim of this study is to develop a new model of muscle hyperalgesia induced by sustained isometric contraction and to study the molecular mechanisms involved in this kind of muscle hyperalgesia, particularly the involvement of P2X3 and P2X2/3.The model is based on the development of a sustained isometric contraction in the gastrocnemius muscle of rats that results in muscle hyperalgesia. The sustained isometric contraction that induces hyperalgesia will be performed by electrical stimulation directly to the belly of the gastrocnemius muscle of rats. Once the model is established, the physiopathologic mechanism of hyperalgesia and the involvement of P2X3 and P2X2/3 receptors will be assessed by techniques of behavioral pharmacology, biochemical analysis and muscle histology. (AU)
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