Mobility modulation in capillary electrophoresis

• Grant number: 12/07361-6
• Support Opportunities: Regular Research Grants
• Start date: March 01, 2013
• End date: May 31, 2016
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal Investigator: Marina Franco Maggi Tavares
• Grantee: Marina Franco Maggi Tavares
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: João Pedro Simon Farah ; Luis Gustavo Dias

Abstract

This project assembles in a concerted manner a number of fundamental studies to improve our ability to manipulate solute mobility for optimization purposes in capillary electrophoresis. A large number of compounds of clinical, forense, pharmaceutical, environmental and food science importance is under consideration comprising homologues series (alkylphenones, alkylphenylketones, halophenols, alkylbenzenes, halobenzenes, benzylamines, crown ethers and alkanes) and functional series (phenolic compounds such as flavonoids, phenolic acids, phenols, etc, terpenes, pesticides, steroids, drugs of abuse, carboxylic acids, amino acids, aliphatic and aromatic amines, food dyes, fatty acids, polycyclic aromatic hydrocarbon, aldehyde and ketones. As a direct outcome, a mobility database (ca. 500 compounds) that might aid solute identification in complex sample matrices will be built using distinct electrolyte systems. For selected classes of solutes, the project comprises studies involving the establishment of solvent effects on acid-base equilibria, cyclodextrin complexation as well as solute-micelle interactions. In addition, the key intermolecular interactions governing solute-surfactant association in pre- and post-micellization regions will be inspected. And finally, micelle solubilization compartments will be probed by quantitative structure retention relationships (QSRR) and molecular dynamics. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CANUTO, GISELE A. B.; OLIVEIRA, DANIEL R.; DA CONCEICAO, LUCAS S. M.; FARAH, JOAO P. S.; TAVARES, MARINA F. M.. Development and validation of a liquid chromatography method for anthocyanins in strawberry (Fragaria spp.) and complementary studies on stability, kinetics and antioxidant power. Food Chemistry, v. 192, p. 566-574, FEB 1 2016. (12/07361-6)

CANUTO, GISELE A. B.; DA CRUZ, PEDRO L. R.; FACCIO, ANDREA T.; KLASSEN, ALINE; TAVARES, MARINA F. M.. Neglected diseases prioritized in Brazil under the perspective of metabolomics: A review. ELECTROPHORESIS, v. 36, n. 18, p. 2336-2347, SEP 2015. (12/07361-6)

GISELE A. B. CANUTO; JOSÉ LUIZ DA COSTA; PEDRO L. R. DA CRUZ; ANA ROSA L. DE SOUZA; ANDRÉA T. FACCIO; ALINE KLASSEN; KARINA T. RODRIGUES; MARINA F. M. TAVARES. METABOLÔMICA: DEFINIÇÕES, ESTADO-DA-ARTE E APLICAÇÕES REPRESENTATIVAS. Química Nova, v. 41, n. 1, p. 75-91, 2018-01-00. (12/09822-0, 12/07361-6, 15/10650-8, 12/51692-7)

BAPTISTA CANUTO, GISELE ANDRE; DORR, FABIANE; GHILARDI LAGO, JOAO HENRIQUE; TEMPONE, ANDRE GUSTAVO; PINTO, ERNANI; PIMENTA, DANIEL CARVALHO; SIMON FARAH, JOAO PEDRO; MANSO ALVES, MARIA JULIA; MAGGI TAVARES, MARINA FRANCO. New insights into the mechanistic action of methyldehydrodieugenol B towards Leishmania (L.) infantum via a multiplatform based untargeted metabolomics approach. METABOLOMICS, v. 13, n. 5, MAY 2017. (15/50075-2, 12/04601-6, 14/25494-9, 12/07361-6, 12/18756-1)

SIROKA, JITKA; POLESEL, DANIEL N.; COSTA, JOSE L.; LANARO, RAFAEL; TAVARES, MARINA F. M.; POLASEK, MIROSLAV. Separation and determination of chlorophenylpiperazine isomers in confiscated pills by capillary electrophoresis. Journal of Pharmaceutical and Biomedical Analysis, v. 84, p. 140-147, OCT 2013. (12/07361-6)