Cerebral anatomy, inflammatory mediators and appetite regulatory hormones in obese pediatrics patients: a neurobiology study of obesity

• Grant number: 12/21677-6
• Support Opportunities: Regular Research Grants
• Duration: September 01, 2013 - February 28, 2017
• Field of knowledge: Health Sciences - Medicine - Psychiatry
• Principal Investigator: Ricardo Riyoiti Uchida
• Grantee: Ricardo Riyoiti Uchida
• Host Institution: Centro de Atenção Integrada à Saúde Mental (CAISM). Santa Casa de Misericórdia de São Paulo. Irmandade da Santa Casa de Misericórdia de São Paulo (ISCMSP). São Paulo , SP, Brazil
• Associated researchers: Bruno Vinicius Kouhiro Aguiar ; Cristiane Kochi ; Fábio Luís de Souza Duran ; Gabriella Forte Matsumoto ; Geraldo Busatto Filho ; Marilia Cerqueira Leite Seelaender ; Pâmela Bertolazzi

Abstract

The incidence of obesity is increasing worldwide, and the same is observed in child population. The increased adiposity is associated to damage to several tissues. Previous voxel-based morphometric and diffusion tensor imaging studies have demonstrated that obese adults have reduced grey matter (GM) in several brain areas and changes in brain connectivity. These data may indicate an increased propensity to obesity, preceding weight gain, or brain tissue affection, as a consequence of obesity. Objectives. The present study will seek volume differences of grey matter and connectivity changes in brain areas that involve the regulation of taste, reward and behavioral control in obese children, linking these differences with blood rates of inflammatory signals, hormones and CNS neuropeptides related to food intake. From this prospective, it will seek precocious brain changes in obesity and its relation with the rated substances Methods. Voxel-based morphometric and diffusion tensor imaging MRI study with 60 obese children and 60 healthy controls, both groups aged 10 to 12 years. Children with clinical, neurological or psychiatric relevant previous diseases will be excluded at the screening. All subjects will be submitted to clinical evaluation such as cardiac frequency, blood pressure, height, weight, body mass index for age (according CDC), and blood rates for glucose, cholesterol, triglycerides, inflammatory mediators (IL1, IL6, IL10, TNF±, PCR and amiloid a)and hormones (leptin, insulin, MSH, MCH and NPY). (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SIMOES, ESTEFANIA; CORREIA-LIMA, JOANNA; SARDAS, LEONARDO; STORTI, FELIPE; OTANI, THAIS ZELIA DOS SANTOS; VASQUES, DANIEL AUGUSTO CORREA; OTANI, VICTOR HENRIQUE OYAMADA; BERTOLAZZI, PAMELA; KOCHI, CRISTIANE; SEELAENDER, MARILIA; et al. Sex dimorphism in inflammatory response to obesity in childhood. International Journal of Obesity, v. 45, n. 4, p. 879-887, APR 2021. (12/50079-0, 12/21677-6)

SIMOES, ESTEFANIA; CORREIA-LIMA, JOANNA; CALFAT, ELIE LEAL DE BARROS; OTANI, THAIS ZELIA DOS SANTOS; VASQUES, DANIEL AUGUSTO CORREA; OTANI, VICTOR HENRIQUE OYAMADA; BERTOLAZZI, PAMELA; KOCHI, CRISTIANE; SEELAENDER, MARILIA; UCHIDA, RICARDO RIYOITI. Sex-Dependent Dyslipidemia and Neuro-Humoral Alterations Leading to Further Cardiovascular Risk in Juvenile Obesity. FRONTIERS IN NUTRITION, v. 7, FEB 12 2021. (12/50079-0, 12/21677-6)