Phenolic composition and biological potential, in vitro and in vivo, from native fruits of Brazil

• Grant number: 13/13190-2
• Support Opportunities: Regular Research Grants
• Duration: October 01, 2013 - September 30, 2015
• Field of knowledge: Agronomical Sciences - Food Science and Technology - Food Science
• Principal Investigator: Severino Matias de Alencar
• Grantee: Severino Matias de Alencar
• Host Institution: Escola Superior de Agricultura Luiz de Queiroz (ESALQ). Universidade de São Paulo (USP). Piracicaba , SP, Brazil
• Associated researchers: Pedro Luiz Rosalen
• Associated grant(s): 14/50235-7 - SMARTHEALTH: chemical composition and bioactive potential of native fruits and edible fungi, AP.R

Abstract

The use of natural products in foods, medicines and cosmetics has become a worldwide tendency and attracted interest of the scientific community and industry as well increasing the phytochemical research and technological application of plant extracts, especially those still underexploited. Considering the Brazilian biodiversity, their potential use and the necessity of a model of sustainable economic development, research involving products truly national take significant importance. This is very important because the native fruits are mostly restricted to communities where the spread occurs spontaneously. The regular consumption of fruits, and its phenolic compounds, has been associated to lower incidence of diseases triggered by oxidative stress such as cancer, diabetes, cardiovascular diseases, and inflammatory processes. The growing apprehension with the use of synthetic antioxidants in foods also suggests the importance of studies about chemical composition and antioxidant activity from native fruits. Therefore, this study aims to evaluate the phenolic composition and antioxidant activity in vitro and anti-inflammatory in vivo from native fruits of Brazil (pulp, peel, seed fruits and leaves), thus increasing the information available on bioactive composition, in the expectation that these results contributes to advances in knowledge, helping to preserve of native flora and generate income to small farmers. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

INFANTE, JULIANA; ROSALEN, PEDRO LUIZ; LAZARINI, JOSY GOLDONI; FRANCHIN, MARCELO; DE ALENCAR, SEVERINO MATIAS. Antioxidant and Anti-Inflammatory Activities of Unexplored Brazilian Native Fruits. PLoS One, v. 11, n. 4, APR 6 2016. (14/50235-7, 13/13190-2)

SOARES, JACKELINE CINTRA; ROSALEN, PEDRO LUIZ; LAZARINI, JOSY GOLDONI; MASSARIOLI, ADNA PRADO; DA SILVA, CAMILA FORTUNATO; NANI, BRUNO DIAS; FRANCHIN, MARCELO; DE ALENCAR, SEVERINO MATIAS. Comprehensive characterization of bioactive phenols from new Brazilian superfruits by LC-ESI-QTOF-MS, and their ROS and RNS scavenging effects and anti-inflammatory activity. Food Chemistry, v. 281, p. 178-188, MAY 30 2019. (13/13190-2, 14/12606-3)

LAZARINI, JOSY GOLDONI; FRANCHIN, MARCELO; INFANTE, JULIANA; RIZZATO PASCHOAL, JONAS AUGUSTO; FREIRES, IRLAN ALMEIDA; DE ALENCAR, SEVERINO MATIAS; ROSALEN, PEDRO LUIZ. Anti-inflammatory activity and polyphenolic profile of the hydroalcoholic seed extract of Eugenia leitonii, an unexplored Brazilian native fruit. Journal of Functional Foods, v. 26, p. 249-257, OCT 2016. (13/26251-0, 13/13190-2)

LAZARINI, JOSY GOLDONI; ORLANDI SARDI, JANAINA DE CASSIA; FRANCHIN, MARCELO; NANI, BRUNO DIAS; FREIRES, IRLAN ALMEIDA; INFANTE, JULIANA; RIZZATO PASCHOAL, JONAS AUGUSTO; DE ALENCAR, SEVERINO MATIAS; ROSALEN, PEDRO LUIZ. Bioprospection of Eugenia brasiliensis, a Brazilian native fruit, as a source of anti-inflammatory and antibiofilm compounds. BIOMEDICINE & PHARMACOTHERAPY, v. 102, p. 132-139, JUN 2018. (13/26251-0, 13/13190-2)

SOARES, JACKELINE CINTRA; ROSALEN, PEDRO LUIZ; LAZARINI, JOSY GOLDONI; ORLANDI SARDI, JANAINA DE CASSIA; MASSARIOLI, ADNA PRADO; NANI, BRUNO DIAS; FRANCHIN, MARCELO; DE ALENCAR, SEVERINO MATIAS. Phenolic profile and potential beneficial effects of underutilized Brazilian native fruits on scavenging of ROS and RNS and anti-inflammatory and antimicrobial properties. FOOD & FUNCTION, v. 11, n. 10, p. 8905-8917, OCT 1 2020. (17/09898-0, 16/02926-6, 13/13190-2)