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Epidemiological study of dengue (serotypes1-4) in a cohort of São José do Rio Preto, São Paulo, Brazil, during 2014-2018

Grant number: 13/21719-3
Support type:Research Projects - Thematic Grants
Duration: June 01, 2015 - May 31, 2020
Field of knowledge:Biological Sciences - Microbiology
Principal Investigator:Maurício Lacerda Nogueira
Grantee:Maurício Lacerda Nogueira
Home Institution: Faculdade de Medicina de São José do Rio Preto (FAMERP). Secretaria de Desenvolvimento Econômico, Ciência e Tecnologia (São Paulo - Estado). São José do Rio Preto, SP, Brazil
Co-Principal Investigators:Francisco Chiaravalloti Neto
Assoc. researchers: Erna Geessien Kroon ; Francisco Chiaravalloti Neto ; João Pessoa Araújo Junior ; Margareth Regina Dibo ; Mauro Martins Teixeira
Associated scholarship(s):15/14313-6 - Genetic and biological characterization of dengue virus, Zika virus and Chikungunya virusisolated in a prospective cohort in SJ Rio Preto, SP, BP.DR
17/21688-1 - Retrospective cohort of pregnant exposed to the Zika virus in São José do Rio Preto in 2016, BP.IC
17/10297-1 - Identification of risk areas for arboviruses using traps for adults of Aedes aegypti and Aedes albopictus and remote sensing images, BP.PD
+ associated scholarships 17/09671-6 - Epidemiological study of dengue (serotypes1-4), Zika e Chikungunya in a cohort of São José do Rio Preto, São Paulo, Brazil: analysis of the first wave results, BE.PQ
16/16344-9 - Clinical and neuropsychiatric caracterization of pacients with dengue diagnosis after acute infection in São José do Rio Preto, during the year 2016, BP.IC
15/12310-0 - Clinical and laboratory characterization of patients diagnosed with dengue, Chikungunya and ZIKA among cohort patients with suspected symptomatology in São José do Rio Preto, in 2016, BP.IC
15/12295-0 - Diagnostic of Brazilian and emergent arboviruses in patients and mosquitoes from two distinct regions in Brazil, BP.PD
15/22750-7 - Assessment of viral and epidemiological fitness differences between two lineages of Dengue serotype 1 co-circulating during 2010-2012 in São José do Rio Preto, SP, BP.DD - associated scholarships


Dengue is an infectious viral disease and one of the most important arboviruses in the world. The virus is maintained in a cycle of urban transmission man - mosquitoes - man: The vector control is a prevention strategies most commonly used. Often the Dengue studies regard only reported cases without grouping data relating to past epidemics. Through a prospective cohort study lasting from five years we will estimate the principal measures taken to disease frequency occurring in a particular neighborhood of the city of São José do Rio Preto, in São Paulo, Brazil. The studies will be relating of the Population that will participate, through by epidemiological and serological lifting, identifying risk factors and evaluation of the knowledge and practices of the population; will be relating of the Virus X Host interaction, by symptoms observations and disease evolution, the presence of antibodies and their classes, presence of specific polymorphisms inducing severe disease and other factors related to this induction; relating of the Virus, identifying serotype and genetic characteristics and its ability to inhibit the production of interferon; and relating of the Vector, through the capture and identification of mosquitoes, the knowledge of their behavior, the correlation of weather data with the presence of the vector and risk factors related to the presence of mosquitoes. These studies involve Laboratories and Research Center in Dengue throughout Brazil and collaborators of the Research in the U.S. The reference center and interconnection shall be Research Virology Lab in Faculdade de Medicina de São José do Rio Preto/FAMERP who receive and distribute all samples, collected in partnership with the prefecture and health services in the municipality. (AU)

Articles published in Agência FAPESP about the research grant
Discovery of Zika virus in monkeys suggests disease may also have wild cycle  
Mechanism that affects multiplication of dengue virus lineage is discovered 
Risk of dengue transmission is measured using number of female mosquitoes  
Risco de transmissão de dengue é medido com base no número de fêmeas do Aedes 
Novel technique detects Zika and dengue in patient samples without using equipment 
Pregnant women should be tested more than once for the presence of Zika 
Prior dengue infection does not increase Zika disease severity 
Babies exposed to Zika in a Brazilian city did not have microcephaly 
Zika can damage babies' brains even in late pregnancy 
Study suggests size of Zika epidemic may be underestimated 
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