Biochemical, physiological and functional genomic studies of Leishmania-macrophage interaction

• Grant number: 14/50717-1
• Support Opportunities: Research Projects - Thematic Grants
• Start date: June 01, 2015
• End date: May 31, 2019
• Field of knowledge: Biological Sciences - Parasitology - Protozoology of Parasites
• Principal Investigator: Lucile Maria Floeter-Winter
• Grantee: Lucile Maria Floeter-Winter
• Host Institution: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The biology of parasites belonging to Leishmania genus offers unique features as model for studying the host - pathogen interaction. Here we propose three sub-projects to study biochemical and physiological aspects of this interaction, primarily upon infe (AU)

Scientific publications

(14)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MUXEL, SANDRA MARCIA; LARANJEIRA-SILVA, MARIA FERNANDA; CARVALHO-SOUSA, CLAUDIA EMANUELLE; FLOETER-WINTER, LUCILE MARIA; MARKUS, REGINA P.. The RelA/cRel nuclear factor-B (NF-B) dimer, crucial for inflammation resolution, mediates the transcription of the key enzyme in melatonin synthesis in RAW 264.7 macrophages. Journal of Pineal Research, v. 60, n. 4, p. 394-404, MAY 2016. (14/50717-1, 10/52688-8, 13/13691-1, 12/15263-4)

FERNANDES, JULIANE C. R.; ACUNA, STEPHANIE M.; AOKI, JULIANA, I; FLOETER-WINTER, LUCILE M.; MUXEL, SANDRA M.. Long Non-Coding RNAs in the Regulation of Gene Expression: Physiology and Disease. NON-CODING RNA, v. 5, n. 1, p. 25-pg., 2019-03-01. (17/23519-2, 14/50717-1, 16/03273-6, 16/19815-2, 18/24693-9, 17/21906-9)

ZAMPIERI, RICARDO ANDRADE; AOKI, JULIANA IDE; MUELLER, KARL ERIK; SHAW, JEFFREY JON; FLOETER-WINTER, LUCILE MARIA. Comparison of Sampling Procedures for the Molecular Diagnosis of Leishmaniases. American Journal of Tropical Medicine and Hygiene, v. 108, n. 3, p. 7-pg., 2023-03-01. (14/50717-1, 18/23512-0)

ACUNA, STEPHANIE MAIA; AOKI, JULIANA IDE; LARANJEIRA-SILVA, MARIA FERNANDA; ZAMPIERI, RICARDO ANDRADE; RIBEIRO FERNANDES, JULIANE CRISTINA; MUXEL, SANDRA MARCIA; FLOETER-WINTER, LUCILE MARIA. Arginase expression modulates nitric oxide production in Leishmania (Leishmania) amazonensis. PLoS One, v. 12, n. 11, NOV 14 2017. (14/50717-1, 15/25942-4, 16/19815-2)

AOKI, JULIANA IDE; MUXEL, SANDRA MARCIA; ZAMPIERI, RICARDO ANDRADE; ACUNA, STEPHANIE MAIA; RIBEIRO FERNANDES, JULIANE CRISTINA; VANDERLINDE, RUBIA HELOISA; OLIVEIRA DE PINHO SALES, MARIA CARMEN; FLOETER-WINTER, LUCILE MARIA. L-arginine availability and arginase activity: Characterization of amino acid permease 3 in Leishmania amazonensis. PLoS Neglected Tropical Diseases, v. 11, n. 10, OCT 2017. (14/50717-1)

RIBEIRO FERNANDES, JULIANE CRISTINA; AOKI, JULIANA IDE; ACUNA, STEPHANIE MAIA; ZAMPIERI, RICARDO ANDRADE; MARKUS, REGINA P.; FLOETER-WINTER, LUCILE MARIA; MUXEL, SANDRA MARCIA. Melatonin and Leishmania amazonensis Infection Altered miR-294, miR-30e, and miR-302d Impacting on Tnf, Mcp-1, and Nos2 Expression. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, v. 9, MAR 20 2019. (16/19815-2, 16/03273-6, 12/15263-4, 14/50717-1, 17/23519-2)

AOKI, JULIANA IDE; LARANJEIRA-SILVA, MARIA FERNANDA; MUXEL, SANDRA MARCIA; FLOETER-WINTER, LUCILE MARIA. The impact of arginase activity on virulence factors of Leishmania amazonensis. Current Opinion in Microbiology, v. 52, p. 110-115, DEC 2019. (17/23933-3, 14/50717-1, 16/03273-6, 16/19815-2)

MUXEL, SANDRA MARCIA; ACUNA, STEPHANIE MAIA; AOKI, JULIANA IDE; ZAMPIERI, RICARDO ANDRADE; FLOETER-WINTER, LUCILE MARIA. Toll-Like Receptor and miRNA-let-7e Expression Alter the Inflammatory Response in Leishmania amazonensis-Infected Macrophages. FRONTIERS IN IMMUNOLOGY, v. 9, NOV 29 2018. (16/03273-6, 17/23519-2, 14/20809-1, 14/50717-1, 16/19815-2)

MUXEL, SANDRA MARCIA; LARANJEIRA-SILVA, MARIA FERNANDA; ZAMPIERI, RICARDO ANDRADE; FLOETER-WINTER, LUCILE MARIA. Leishmania (Leishmania) amazonensis induces macrophage miR-294 and miR-721 expression and modulates infection by targeting NOS2 and L-arginine metabolism. SCIENTIFIC REPORTS, v. 7, MAR 9 2017. (14/50717-1, 10/52688-8, 14/20809-1, 12/15263-4)

AOKI, JULIANA IDE; MUXEL, SANDRA MARCIA; ZAMPIERI, RICARDO ANDRADE; LARANJEIRA-SILVA, MARIA FERNANDA; MULLER, KARL ERIK; NERLAND, AUDUN HELGE; FLOETER-WINTER, LUCILE MARIA. RNA-seq transcriptional profiling of Leishmania amazonensis reveals an arginasedependent gene expression regulation. PLoS Neglected Tropical Diseases, v. 11, n. 10, OCT 2017. (14/50717-1)

MUXEL, SANDRA M.; AOKI, JULIANA I.; FERNANDES, JULIANE C. R.; LARANJEIRA-SILVA, MARIA F.; ZAMPIERI, RICARDO A.; ACUNA, STEPHANIE M.; MULLER, KARL E.; VANDERLINDE, RUBIA H.; FLOETER-WINTER, LUCILE M.. Arginine and Polyamines Fate in Leishmania Infection. FRONTIERS IN MICROBIOLOGY, v. 8, JAN 15 2018. (16/22896-4, 14/50717-1, 15/25942-4, 16/19815-2)

ACUNA, STEPHANIE MAIA; ZANATTA, JONATHAN MIGUEL; DE ALMEIDA BENTO, CAMILLA; FLOETER-WINTER, LUCILE MARIA; MUXEL, SANDRA MARCIA. iR-294 and miR-410 Negatively Regulate Tnfa, Arginine Transporter Cat1/2, and Nos2 mRNAs in Murine Macrophages Infected with Leishmania amazonensi. ON-CODING RN, v. 8, n. 1, FEB 2022. (18/24693-9, 19/07089-3, 18/18499-5, 17/23519-2, 14/50717-1)

AOKI, JULIANA IDE; MUXEL, SANDRA MARCIA; LARANJEIRA-SILVA, MARIA FERNANDA; ZAMPIERI, RICARDO ANDRADE; MULLER, KARL ERIK; NERLAND, AUDUN HELGE; FLOETER-WINTER, LUCILE MARIA. Dual transcriptome analysis reveals differential gene expression modulation influenced by Leishmania arginase and host genetic background. MICROBIAL GENOMICS, v. 6, n. 9, p. 13-pg., 2020-09-01. (14/50717-1, 16/03273-6, 17/23933-3, 18/24693-9, 18/23512-0)

AOKI, JULIANA IDE; MUXEL, SANDRA MARCIA; ZAMPIERI, RICARDO ANDRADE; MUELLER, KARL ERIK; NERLAND, AUDUN HELGE; FLOETER-WINTER, LUCILE MARIA. Differential immune response modulation in early Leishmania amazonensis infection of BALB/c and C57BL/6 macrophages based on transcriptome profiles (vol 9, 19841, 2019). SCIENTIFIC REPORTS, v. 10, n. 1, p. 1-pg., 2020-03-04. (18/24693-9, 14/50717-1, 16/03273-6, 18/23512-0)