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Matrix effect on vehiculation and functionality of pre and probiotics: study in a dynamic colonic model and with volunteers from the preparatory school of army cadets from Campinas

Grant number: 17/25007-9
Support type:Regular Research Grants
Duration: April 01, 2018 - March 31, 2020
Field of knowledge:Agronomical Sciences - Food Science and Technology
Principal Investigator:Adriane Elisabete Antunes de Moraes
Grantee:Adriane Elisabete Antunes de Moraes
Home Institution: Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil
Assoc. researchers: Ângela Giovana Batista ; Darlila Aparecida Gallina ; Fernando Moreira Simabuco ; Glaucia Maria Pastore ; Katia Sivieri ; Mário Roberto Maróstica Junior ; Rosangela dos Santos
Associated scholarship(s):18/18366-5 - Culture-based and non-culture based techniques for analysis of probiotics and metabolites of the microbiota, BP.TT


The state of the art on pre and probiotic does not present a definitive answer on the best way of delivery of them. The objective of the present study is to compare one food matriz (ice cream obtained on a semi-industrial scale) and a lyophilized food supplement containing the same amounts of inulin, Lactobacillus acidophilus LA-5 and Bifidobacterium animalis subsp. lactis BB-12. Static simulated digestion (metabolic bath) and dynamics (simulator of the human gastrointestinal tract) will be employed. The viability, metabolic state, cellular morphology and viability (by techniques based or not on cultivation) of the probiotics in ice cream and lyophilized food supplement will be obtained. At the final step of the research a double blind clinical study will be made to evaluate the effect of supplementation of volunteers of the Preparatory School of Cadets of Campinas / SP in parameters of microbiota, gut-brain axis and general health. All variables will be analyzed for their distribution. The results of the microbiota analysis will undergo bioinformatics treatment. Variables involving humans will be compared by paired tests (paired t-student or Wilcoxon) before and after the proposed intervention. Correlation and association tests will be performed to verify the relationship of the variables. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RODRIGUES, VIVIAN CRISTINA DA CRUZ; DUQUE, ANA LUIZA ROCHA FARIA; FINO, LUCIANA DE CARVALHO; SIMABUCO, FERNANDO MOREIRA; SARTORATTO, ADILSON; CABRAL, LUCELIA; NORONHA, MELLINE FONTES; SIVIERI, KATIA; ANTUNES, ADRIANE ELISABETE COSTA. Modulation of the intestinal microbiota and the metabolites produced by the administration of ice cream and a dietary supplement containing the same probiotics. BRITISH JOURNAL OF NUTRITION, v. 124, n. 1, p. 57-68, JUL 14 2020. Web of Science Citations: 0.
DA CRUZ RODRIGUES, VIVIAN CRISTINA; SALVINO DA SILVA, LUIZ GUILHERME; SIMABUCO, FERNANDO MOREIRA; VENEMA, KOEN; COSTA ANTUNES, ADRIANE ELISABETE. Survival, metabolic status and cellular morphology of probiotics in dairy products and dietary supplement after simulated digestion. Journal of Functional Foods, v. 55, p. 126-134, APR 2019. Web of Science Citations: 1.

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