Plurimetabolic syndrome in dermatomyositis/polymyositis

• Grant number: 11/15524-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: November 01, 2011
• End date: October 31, 2012
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Samuel Katsuyuki Shinjo
• Grantee: Mariana Teichner de Moraes
• Host Institution: Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of chronic autoimmune diseases, systemic, associated with high morbidity and functional disability. Concerning to the clinical and histopathological features, the MII can be classified into polymyositis (PM), dermatomyositis (DM), juvenile dermatomyositis, myositis, a corpuscle, myositis associated with malignancy, and myositis associated with other collagen diseases. In relation to metabolic syndrome (PMS), it is a multifactorial disease of elevated prevalence. It is a series of disorders characterized by biochemical and physiological changes in fasting glucose levels, central obesity, dyslipidemia, and hypertension. In the few available studies, the prevalence of PMS in systemic autoimmune rheumatic diseases ranges from 14 to 62.8% and is thus higher than in the general population. This high prevalence suggests that the presence or treatment of autoimmune diseases systemic influences the risk of developing PMS. However, to our knowledge, no studies in the literature, assessing the prevalence, as well as the impact of SPM in IIM, motivated us to conduct this study.(AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE MORAES, MARIANA TEICHNER; CARLOS DE SOUZA, FERNANDO HENRIQUE; MORAES DE BARROS, THIAGO BITAR; SHINJO, SAMUEL KATSUYUKI. Analysis of Metabolic Syndrome in Adult Dermatomyositis With a Focus on Cardiovascular Disease. ARTHRITIS CARE & RESEARCH, v. 65, n. 5, p. 793-799, MAY 2013. (11/15524-0)