Advanced search
Start date

Studies towards the synthesis of Phenantroindolizidines

Grant number: 11/15903-0
Support type:Scholarships in Brazil - Master
Effective date (Start): March 01, 2012
Effective date (End): February 28, 2014
Field of knowledge:Physical Sciences and Mathematics - Chemistry
Principal Investigator:Antonio Carlos Bender Burtoloso
Grantee:Ariane Fernandes Bertonha
Home Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil


The strategy envisages the use of chloroketones for the synthesis of indolizidines, specifically the fenantroindolizidines. This proposal constitutes an innovative approach, allowing not only the synthesis of fenantroindolizidinas, as well as the synthesis of other indolizidine alkaloids. In this project, the phenantroindolizidine alkaloid antofine was selected as a synthetic targets in view of its interesting anti-cancer activities.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BURTOLOSO, ANTONIO C. B.; BERTONHA, ARIANE F.; ROSSET, ISAC G. Synthesis of Alkaloids: Recent Advances in the Synthesis of Phenanthroindolizidine Alkaloids. CURRENT TOPICS IN MEDICINAL CHEMISTRY, v. 14, n. 2, p. 191-199, JAN 2014. Web of Science Citations: 16.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
BERTONHA, Ariane Fernandes. Construction of 6-aryl indolizidine skeleton from α-chloroketones derived from (S)-proline: synthesis of (S)-desoxiipalbidina. 2014. Master's Dissertation - Universidade de São Paulo (USP). Instituto de Química de São Carlos São Carlos.

Please report errors in scientific publications list by writing to: