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Grant number: 12/15098-3
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): March 01, 2013
Effective date (End): December 31, 2013
Field of knowledge:Agronomical Sciences - Animal Husbandry - Animal Production
Principal Investigator:Angélica Simone Cravo Pereira
Grantee:Bruno Lapo Utembergue
Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:11/21241-0 - Study of the genetic variability of meat fatty acid profile in Nelore cattle finished in feedlot, AP.JP


Among the attributes of beef meat, the fatty acid profile is importantbecause it affects not only the meat palatability, but also the human health. Inrecent years, fatty acids harmful to human health have received considerableattention. Several studies, working with taurine breeds, showed that there isgenetic variability for meat fatty acid profile and, therefore the possibility ofgenetic improvement of fatty acid composition in beef cattle. Moreover, theresults of these studies showed favorable genetic correlations estimatesbetween fatty acids. However, genetic parameter estimates for fatty acid profilein zebu cattle are scarce. The objective of this project is to study the geneticvariability of meat fatty acid profile in Nelore cattle finished in feedlot conditions,and implement models and methods that use genomic information to improvethe fatty acid composition of beef meat. To attain this objective we propose thefollowing specific objective: Verified the expression patterns of genes involvedin lipid metabolism and fatty acid synthesis of the fatty acids palmitic (C16: 0),stearic (C18: 0), oleic (C18: 1 cis-9), linoleic (C18: 2 cis-9cis-12), CLA (C18: 2cis-9 trans-11) and linolenic (C18: 3) in Nellore cattle feedlot. Will be used 54Nellore and after slaughter will be analyzed for fatty acid profile, lipid extraction,profile of triacylglycerols (TAG) and Quantification of expression by newgeneration sequencing (RNA-Seq), to evaluate the relationship betweenexpression of genes found and the profile of fatty acids.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BERTON, MARIANA P.; FONSECA, LARISSA F. S.; GIMENEZ, DANIELA F. J.; UTEMBERGUE, BRUNO L.; CESAR, ALINE S. M.; COUTINHO, LUIZ L.; DE LEMOS, MARCOS VINICIUS A.; ABOUJAOUDE, CAROLYN; PEREIRA, ANGELICA S. C.; DE O SILVA, RAFAEL M.; et al. Gene expression profile of intramuscular muscle in Nellore cattle with extreme values of fatty acid. BMC Genomics, v. 17, . (09/16118-5, 12/15098-3)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
UTEMBERGUE, Bruno Lapo. Study of the gene expression associated to fatty acid profile in Nellore cattle feedlot. 2014. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina Veterinária e Zootecnia (FMVZ/SBD) Pirassununga.

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