Interaction between T lymphocytes, Blymphocytes and plasmacytoid dendritic cells in patients optical neuromyelitis

• Grant number: 13/00640-0
• Support Opportunities: Scholarships in Brazil - Master
• Start date: May 01, 2013
• End date: August 31, 2014
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Principal Investigator: Leonilda Maria Barbosa dos Santos
• Grantee: Marília Domingues de Andrade
• Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Neuromyelitis optica (NMO) is an autoimmune demyelinating disease of the central nervous system. Although about 20% of patients do not exhibit anti aquaporin 4 (AQP4 antibodies, there is evidence that tissue damage is more severe in patients with autoantibodies to AQP4. This antibody belongs to the class IgG1 and therefore depends on the cooperation of CD4 for its synthesis. In this proposal, our goal is to study the B lymphocyte subpopulations in patients with NMO, as well as the participation of plasmacytoid dendritic cells (PDCs), determination of IFN-± in the serum of these patients, and the interaction of these two cell subpopulations (B cells and PDCs) with CD4 T lymphocytes.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

ANDRADE, Marília Domingues de. Study of B lymphocytes subpopulations in patients with neuromyelitis optica. 2015. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia Campinas, SP.