Assessment of the ecogenotoxicologic risk of using textile dyes.

• Grant number: 13/09317-7
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: September 01, 2013
• End date: September 30, 2016
• Field of knowledge: Health Sciences - Pharmacy - Toxicological Analysis
• Principal Investigator: Danielle Palma de Oliveira
• Grantee: Otávio Pelegrino Rocha
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated research grant: 08/10449-7 - Assessment of occurrence, toxicity/genotoxicity and degradation processes of dyes in effluents and surface water, AP.TEM

Abstract

The dyes are responsible for the movement of billions of dollars each year through the production of millions of tons, concerning from the standpoint of environment and health of the exposed population, since an estimated 15 % of world production of dyes loss to the aquatic environment during the synthesis, processing and their application. Published studies on the mutagenic and genotoxic samples containing dyes and pigments coming from tannery wastewater and surface related water do not identify the exact chemical compounds responsible for these activities. The present study aims to evaluate the occurrence and toxicity of dyes in tannery wastewater and surface related water, in order to obtain subsidies to better understand the mechanisms of toxic effects on genetic material as well as their environmental transport processes. The study will be realized by genetic toxicology assays, including the mutagenicity assays with Salmonella and comet assay in HepG2 and fibloblastos human skin. The presence of dyes in environmental samples will be determined by LC / MS in collaboration with the Institute of Chemistry, UNESP, Araraquara-SP. With the results of this project will be possible to perform the preliminary assessment of the risk of the release of these compounds in the aquatic environment.

Scientific publications

(4)

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

ROCHA, OTAVIO PELEGRINO; CESILA, CIBELE APARECIDA; CHRISTOVAM, ELISA MARIA; DE MORAES BARROS, SILVIA BERLANGA; BOLDRIN ZANONI, MARIA VALNICE; DE OLIVEIRA, DANIELLE PALMA. Ecotoxicological risk assessment of the "Acid Black 210" dye. Toxicology, v. 376, p. 7-pg., 2017-02-01. (08/10449-7, 13/09317-7, 13/06172-8, 13/24340-5)

ROCHA, OTAVIO PELEGRINO; DE OLIVEIRA, DANIELLE PALMA. Investigation of a Brazilian tannery effluent by means of zebra fish (Danio rerio) embryo acute toxicity (FET) test. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, v. 80, n. 19-21, SI, p. 1078-1085, 2017. (13/09317-7, 08/10449-7)

ROCHA, OTAVIO PELEGRINO; CESILA, CIBELE APARECIDA; CHRISTOVAM, ELISA MARIA; DE MORAES BARROS, SILVIA BERLANGA; BOLDRIN ZANONI, MARIA VALNICE; DE OLIVEIRA, DANIELLE PALMA. Ecotoxicological risk assessment of the ``Acid Black 210{''} dye. Toxicology, v. 376, n. SI, p. 113-119, FEB 1 2017. (13/09317-7, 13/24340-5, 08/10449-7, 13/06172-8)

ROCHA, OTAVIO PELEGRINO; DE OLIVEIRA, DANIELLE PALMA. Investigation of a Brazilian tannery effluent by means of zebra fish (Danio rerio) embryo acute toxicity (FET) test. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, v. 80, n. 19-21, p. 8-pg., 2017-01-01. (08/10449-7, 13/09317-7)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

ROCHA, Otávio Pelegrino. Assessment of the ecogenotoxicologic risk of using textile dyes. 2016. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (PCARP/BC) Ribeirão Preto.