Peptide and chitosan conjugates with pharmacological potential: synthesis, prospecting of activity in membrane mimetic systems, and evaluation in cells

• Grant number: 14/08372-7
• Support Opportunities: Scholarships in Brazil - Young Researchers
• Start date: June 01, 2014
• End date: April 30, 2018
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Marcia Perez dos Santos Cabrera
• Grantee: Marcia Perez dos Santos Cabrera
• Host Institution: Instituto de Biociências, Letras e Ciências Exatas (IBILCE). Universidade Estadual Paulista (UNESP). Campus de São José do Rio Preto. São José do Rio Preto , SP, Brazil
• Associated research grant: 12/24259-0 - Peptide and chitosan conjugates with pharmacological potential: synthesis, prospecting of activity in membrane mimetic systems, and evaluation in cells, AP.JP

Scientific publications

(13)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LEITE, NATALIA B.; MARTINS, DANUBIA B.; FAZANI, VINICIUS E.; VIEIRA, MAIRA R.; DOS SANTOS CABRERA, MARCIA P.. Cholesterol modulates curcumin partitioning and membrane effects. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, v. 1860, n. 11, p. 2320-2328, NOV 2018. (14/06713-1, 14/08372-7, 14/11877-3, 12/24259-0)

MARTINS, DANUBIA BATISTA; FADEL, VALMIR; OLIVEIRA, FILIPA D.; GASPAR, DIANA; ALVARES, DAYANE S.; CASTANHO, MIGUEL A. R. B.; CABRERA, MARCIA PEREZ DOS SANTOS. Protonectin peptides target lipids, act at the interface and selectively kill metastatic breast cancer cells while preserving morphological integrity. Journal of Colloid and Interface Science, v. 601, p. 517-530, NOV 2021. (15/25620-7, 14/08372-7, 12/24259-0)

DIAS, AMANDA MANCHINI; DOS SANTOS CABRERA, MARCIA PEREZ; FURUYAMA LIMA, ALINE MARGARETE; TABOGA, SEBASTIAO ROBERTO; LEITE VILAMAIOR, PATRICIA SIMONE; TIERA, MARCIO JOSE; DE OLIVEIRA TIERA, VERA APARECIDA. Insights on the antifungal activity of amphiphilic derivatives of diethylaminoethyl chitosan against Aspergillus flavus. Carbohydrate Polymers, v. 196, p. 433-444, SEP 15 2018. (16/15736-0, 14/08372-7)

MEDEIROS, DJALMA; SILVA-GONCALVES, LAIZ DA COSTA; BRITO DA SILVA, ANNIELLE MENDES; DOS SANTOS CABRERA, MARCIA PEREZ; ARCISIO-MIRANDA, MANOEL. Membrane-mediated action of the endocannabinoid anandamide on membrane proteins: implications for understanding the receptor-independent mechanism. SCIENTIFIC REPORTS, v. 7, JAN 27 2017. (12/02065-0, 12/24259-0, 14/08372-7)

MARTINS, DANUBIA BATISTA; VIEIRA, MAIRA RAMOS; FADEL, VALMIR; CAMARGO SANTANA, VIVIANE APARECIDA; RODRIGUES GUERR, MIRIAN ELISA; LIMA, MARTA LOPES; TEMPONE, ANDRE G.; DOS SANTOS CABRERA, MARCIA PEREZ. Membrane targeting peptides toward antileishmanial activity: Design, structural determination and mechanism of interaction. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, v. 1861, n. 11, A, p. 2861-2871, NOV 2017. (15/17331-5, 12/24259-0, 14/11877-3, 14/08372-7, 13/50228-8)

MARTINS, DANUBIA BATISTA; PACCA, CAROLINA COLOMBELLI; DA SILVA, ANNIELLE MENDES BRITO; DE SOUZA, BIBIANA MONSON; DE ALMEIDA, MARGARETE TERESA GOTTARDO; PALMA, MARIO SERGIO; ARCISIO-MIRANDA, MANOEL; DOS SANTOS CABRERA, MARCIA PEREZ. Comparing activity, toxicity and model membrane interactions of Jelleine-I and Trp/Arg analogs: analysis of peptide aggregation. Amino Acids, v. 52, n. 5, MAY 2020. (16/16212-5, 16/13368-4, 16/17951-6, 14/08372-7, 12/24259-0)

RANGEL, MARISA; DOS SANTOS CASTRO, FABIOLA FERNANDES; MOTA-LIMA, LILIAN DAIENE; CLISSA, PATRICIA BIANCA; MARTINS, DANUBIA BATISTA; DOS SANTOS CABRERA, MARCIA PEREZ; MORTARI, MARCIA RENATA. Polydim-I antimicrobial activity against MDR bacteria and its model membrane interaction. PLoS One, v. 12, n. 6, JUN 1 2017. (12/24259-0, 14/08372-7, 08/00173-4)

COSTA PETRIN, THAIS H.; FADEL, VALMIR; MARTINS, DANUBIA B.; DIAS, SUSANA A.; CRUZ, ANA; SERGIO, LUCIANA MARCIANO; ARCISIO-MIRANDA, MANOEL; CASTANHO, MIGUEL A. R. B.; DOS SANTOS CABRERA, MARCIA P.. Synthesis and Characterization of Peptide-Chitosan Conjugates (PepChis) with Lipid Bilayer Affinity and Antibacterial Activity. Biomacromolecules, v. 20, n. 7, p. 2743-2753, JUL 2019. (14/08372-7, 16/13368-4, 15/07548-7, 12/02065-0, 12/24259-0)

MARTINS, DANUBIA BATISTA; NASARIO, FABIO DOMINGUES; SILVA-GONCALVES, LAIZ COSTA; DE OLIVEIRA TIERA, VERA APARECIDA; ARCISIO-MIRANDA, MANOEL; TIERA, MARCIO JOSE; DOS SANTOS CABRERA, MARCIA PEREZ. Chitosan derivatives targeting lipid bilayers: Synthesis, biological activity and interaction with model membranes. Carbohydrate Polymers, v. 181, p. 1213-1223, FEB 1 2018. (12/02065-0, 09/11707-2, 10/11823-0, 12/24259-0, 12/03619-9, 14/08372-7)

RODRIGUES GUERRA, MIRIAN ELISA; FADEL, VALMIR; MALTAROLLO, VINICIUS GONCALVES; BALDISSERA, GISELE; HONORIO, KATHIA MARIA; RUGGIERO, JOSE ROBERTO; DOS SANTOS CABRERA, MARCIA PEREZ. MD simulations and multivariate studies for modeling the antileishmanial activity of peptides. CHEMICAL BIOLOGY & DRUG DESIGN, v. 90, n. 4, p. 501-510, OCT 2017. (06/57122-7, 12/24259-0, 14/08372-7)

BALDISSERA, GISELE; DOS SANTOS CABRERA, MARCIA PEREZ; CHAHINE, JORGE; RUGGIERO, JOSE ROBERTO. Role of Peptide Peptide Interactions in Aggregation: Protonectins Observed in Equilibrium and Replica Exchange Molecular Dynamics Simulations. BIOCHEMISTRY, v. 54, n. 13, p. 2262-2269, APR 7 2015. (06/57122-7, 14/08372-7, 10/11823-0)

LEITE, NATALIA BUENO; MARTINS, DANUBIA BATISTA; ALVARES, DAYANE S.; DOS SANTOS CABRERA, MARCIA PEREZ. Quercetin induces lipid domain-dependent permeability. Chemistry and Physics of Lipids, v. 242, p. 11-pg., 2022-01-01. (14/11877-3, 14/06713-1, 12/24259-0, 14/08372-7)

MARTINS, DANUBIA BATISTA; VIEIRA, MAIRA RAMOS; FADEL, VALMIR; CAMARGO SANTANA, VIVIANE APARECIDA; RODRIGUES GUERR, MIRIAN ELISA; LIMA, MARTA LOPES; TEMPONE, ANDRE G.; DOS SANTOS CABRERA, MARCIA PEREZ. Membrane targeting peptides toward antileishmanial activity: Design, structural determination and mechanism of interaction. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, v. 1861, n. 11, p. 11-pg., 2017-11-01. (13/50228-8, 14/11877-3, 12/24259-0, 14/08372-7, 15/17331-5)