Characterization of Cordia Verbenacea DC sustained release using natural latex biomembranes as carrier

• Grant number: 14/11037-5
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: August 01, 2014
• End date: July 31, 2015
• Field of knowledge: Engineering - Biomedical Engineering - Bioengineering
• Principal Investigator: Rondinelli Donizetti Herculano
• Grantee: Vitória de Sousa Chao
• Host Institution: Faculdade de Ciências e Letras (FCL-ASSIS). Universidade Estadual Paulista (UNESP). Campus de Assis. Assis , SP, Brazil

Abstract

The Natural Rubber Latex (NRL) membrane manipulated from the latex extracted from the rubber tree Hevea brasiliensis, has shown great potential for biomedical applications and as biomaterials. Due to its biocompatibility and low risk of rejection, it can stimulate angiogenesis, cellular adhesion and the formation of extracellular matrix, besides acting as a mechanical barrier to infectious agents. The aim of this study is to develop a novel sustained delivery system for Cordia verbenacea DC. based on Natural Rubber Latex (NRL) membranes and to study the Cordia Verbenacea DC. delivery system behavior. The Cordia Verbenacea DC. is an anti-inflammatory, anti-ulcer, anti-rheumatic and healing plant that has therapeutic properties and low toxicity, thanks to the action of the essential oil, which has the active ingredient alpha-humulene. The use of a controlled release system, coupled with the angiogenic properties of latex, seeking to extract-biomembrane interaction, and thus ensure the improvement of the effects of the herbal medicine, as well as offering a cheaper and affordable alternative to those existing in market. The release rates of extract the complex drug-extract-film will be monitored and analyzed, using the method of optical spectroscopy (UV-VIS), and will be characterized by Scanning Electron Microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy and mechanical resistance tests.

Scientific publications

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

FLORIANO, JULIANA F.; CHAO, VITORIA DE SOUSA; BOLOGNESI, LUIS F. C.; DE BARROS, NATAN R.; MIRANDA, MATHEUS C. R.; BORGES, FELIPE A.; CHAGAS, ANA LAURA D.; PAULINO, CRISTIANE G.; GARMS, BRUNA C.; MARCELINO, MONICA Y.; et al. Physical, Chemical and Biological Characterization of Natural Rubber Latex Membranes Loaded with Cordia verbenacea DC. Extract. CURRENT TRADITIONAL MEDICINE, v. 4, n. 2, p. 15-pg., 2018-01-01. (11/17411-8, 14/17526-8, 14/11037-5)

FLORIANO, JULIANA F.; CHAO, VITORIA DE SOUSA; BOLOGNESI, LUIS F. C.; DE BARROS, NATAN R.; MIRANDA, MATHEUS C. R.; BORGES, FELIPE A.; CHAGAS, ANA LAURA D.; PAULINO, CRISTIANE G.; GARMS, BRUNA C.; MARCELINO, MONICA Y.; et al. Physical, Chemical and Biological Characterization of Natural Rubber Latex Membranes Loaded with Cordia verbenacea DC. Extract. JOURNAL OF FUNGI, v. 4, n. 2, p. 140-154, 2018. (14/17526-8, 14/11037-5, 11/17411-8)