AC Biosusceptometry to assess accumulation of cancer-targeted magnetic nanoparticles in tumors for diagnostic and therapy

• Grant number: 15/14914-0
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: November 01, 2015
• End date: June 30, 2018
• Field of knowledge: Biological Sciences - Biophysics - Biophysics of Processes and Systems
• Principal Investigator: José Ricardo de Arruda Miranda
• Grantee: Caio César Quini
• Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
• Associated scholarship(s): 17/00842-2 - Developing a molecularly-correlated AC biosusceptometry system to detect and quantitate nerve fiber damage, BE.EP.PD

Abstract

Thanks to its unique versatility, nanotechnology offers new diagnosis and therapy alternatives for cancer treatment, even in different stages of the disease. However, these theranostic properties are often limited by the lack of an accurate method to detect and explore their properties. The main purpose of this project is optimizing and applying the AC Biosusceptometry (BAC) technique as an in vivo detection and monitoring system for magnetic nanoparticles (MNP) tumor accumulation. The Biosusceptometry system, extensively applied to physiological gastrointestinal tract studies, offers a viable, portable and versatile alternative to monitor MNP distribution through tissues and organs of interest. Thus, in this project, we aim to validate the BAC system as a detection and monitoring tool for tumor accumulation of magnetic nanoparticles in mice. Also, by optimizing the nanoparticles coating process, we intend to enhance tumor accumulation for further hyperthermia (HT) treatment. Since HT is dependent upon particles concentration in the tumor site, we strongly believe we can increase treatment efficiency by applying real time MNP concentration monitoring to enhance heat delivery.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

QUINI, CAIO C.; PROSPERO, ANDRE G.; CALABRESI, MARCOS F. F.; MORETTO, GUSTAVO M.; ZUFELATO, NICHOLAS; KRISHNAN, SUNIL; PINA, DIANA R.; OLIVEIRA, RICARDO B.; BAFFA, OSWALDO; BAKUZIS, ANDRIS F.; et al. Real-time liver uptake and biodistribution of magnetic nanoparticles determined by AC biosusceptometry. Nanomedicine-Nanotechnology Biology and Medicine, v. 13, n. 4, p. 1519-1529, MAY 2017. (10/07639-9, 13/20842-6, 11/18696-6, 15/14914-0)

QUINI, CAIO C.; PROSPERO, ANDRE G.; KONDILES, BETHANY R.; CHABOUB, LESLEY; HOGAN, MATTHEW K.; BAFFA, OSWALDO; BAKUZIS, ANDRIS F.; HORNER, PHILIP J.; MIRANDA, JOSE R. A.. Development of a protocol to assess cell internalization and tissue uptake of magnetic nanoparticles by AC Biosusceptometry. Journal of Magnetism and Magnetic Materials, v. 473, p. 527-533, MAR 1 2019. (17/00842-2, 15/14914-0)