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Application of Counter-Current Chromatography for the Secondary Metabolites isolation from two Native Brazilian Sapindaceae

Grant number: 16/07079-0
Support Opportunities:Scholarships abroad - Research
Effective date (Start): June 27, 2016
Effective date (End): August 02, 2016
Field of knowledge:Health Sciences - Pharmacy - Pharmacognosy
Principal Investigator:Fabiana Lima Silva
Grantee:Fabiana Lima Silva
Host Investigator: Svetlana Nikolaevna Ignatova
Host Institution: Instituto de Ciências da Saúde (ICS). Universidade Paulista (UNIP). São Paulo , SP, Brazil
Research place: Brunel University, England  

Abstract

Chromatography countercurrent (CCC) is a very advantageous technique for recovery, purification and isolation of natural products due to the liquid nature of its stationary phase, which prevents the retention of the compounds in the matrix, its reproducibility, the possibility of scale-up, among others. In this work aims to develop methodologies for isolating of compounds from ethyl acetate and n-butanol phases of two species of Sapindaceae, Cardiospermum corindum L. and Serjana caracasana (Jacq.) Willd., taking into account the principles of greater yield of each compound associated with lower consumption of solvent systems and reduced time spent in the process. In previous work by our group obtained compounds of chemotaxonomic value in more nonpolar phases of plant species and still observe biological activities associated with the extracts and organic phases. Thus, since the polar organic phases are shown promise as the biological activity and earlier work of other groups studied species of the genus concerned reported the presence of secondary metabolites classes chemotaxonomic value and biological interest, are justified by the studies that address the isolation of compounds present in such organic phase by means of a CCC separation techniques widely used.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SILVA, FABIANA LIMA; HRIHOROWITSCH MORENO, PAULO ROBERTO; FRANKLAND SAWAYA, ALEXANDRA CHRISTINE HELENA; DE FREITAS LEMESZENKI, GIOVANA CASSIA; HEWITSON, PETER; IGNATOVA, SVETLANA. Dereplication of Phenolics from Cardiospermum corindum by Countercurrent Chromatography Combined with Liquid Chromatography-Electrospray Mass Spectrometry. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 32, n. 2, p. 6-pg., . (16/07079-0)

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