Effect of addition of sodium hexametaphosphate nano-sized in fluoride toothpastes on the process of demineralization dental: study in situ

• Grant number: 16/03148-7
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: July 01, 2016
• End date: June 30, 2018
• Field of knowledge: Health Sciences - Dentistry - Pediatric Dentistry
• Principal Investigator: Marcelle Danelon
• Grantee: Matheus dos Passos Silva
• Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil

Abstract

The potentiation of the effect of conventional toothpastes is essential to reduce the prevalence of dental caries in high risk patients. The objective of this study is to evaluate, in situ, the ability of a dentifrice containing nanoparticulate sodium hexametaphosphate (HMPnano) associated with fluoride (F), to reduce the demineralization of dental enamel. They will be held 4 experimental periods lasting seven days each, and 7-day washout between them being blind crossover study. bovine enamel blocks (n = 192) will be selected through the initial surface hardness (SHI) and then twelve volunteers (n = 12) use palatal appliances containing 4 enamel blocks for 7 days in 4 experimental phases: 1) toothpaste no F/HMPnano (Placebo); 2) toothpaste 1100 ppm F (1100 ppm F); 3) toothpaste 1100 ppm associated with 0.5% HMP microparticle (1100 0.5%HMPmicro) and 4) toothpaste 1100 ppm associated with 0.5% HMP nanoparticulate (1100 0.5% HMPnano). The cariogenic challenge will be produced by using a sucrose 30% solution. In enamel blocks will be determined the hardness of the end surface (SHF) for calculating the surface hardness loss percentage (%SH). the most appropriate statistical test to the distribution of the data will be used by the statistical program Sigmaplot© software for Windows version 12.0, with a significance level of 5%. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GONZALES GARCIA, LUHANA SANTOS; BOTAZZO DELBEM, ALBERTO CARLOS; PESSAN, JULIANO PELIM; SILVA, MATHEUS DOS PASSOS; SOUZA NETO, FRANCISCO NUNES; GORUP, LUIZ FERNANDO; DE CAMARGO, EMERSON RODRIGUES; DANELON, MARCELLE. Anticaries effect of toothpaste with nano-sized sodium hexametaphosphate. CLINICAL ORAL INVESTIGATIONS, v. 23, n. 9, p. 3535-3542, SEP 2019. (16/03148-7)