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Bioinformatic analysis of QTLs mapping by high-throughput sequencing to identification of robustness mechanisms of industrial yeast

Grant number: 14/26905-2
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): August 01, 2016
Effective date (End): March 31, 2017
Field of knowledge:Biological Sciences - Genetics
Principal Investigator:Marcelo Falsarella Carazzolle
Grantee:Sheila Tiemi Nagamatsu
Home Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Besides the fact that Brazil is one of the most important world producers of first generation ethanol and it has hundreds plants in its national territory, this process present technological limitations which have encouraged the pursuit for new alternatives, the main one is second generation ethanol that aim use biomass as feedstock. Both first and second generation production present limiting factors to fermentation stage, among them temperature variation, pH alterations, inhibitory molecules and high ethanol concentration. Thus, industrial yeast development to robustness of this factor is an essential step to increase the competitiveness. The genomic study of ethanol industrial yeast have had great importance in gene identification and metabolic pathway associated to robustness, furthermore, this methodology could be useful to select more efficient wild strain to a desirable feature. In this context, the objective of this study is developing a bioinformatics methodology to analyze QTL maps in industrial yeast using ISA (Individual Segregant Analysis) to detect genomic regions linked to the phenotypes of interest. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE CARVALHO, L. M.; BORELLI, G.; CAMARGO, A. P.; DE ASSIS, M. A.; DE FERRAZ, S. M. F.; FIAMENGHI, M. B.; JOSE, J.; MOFATTO, L. S.; NAGAMATSU, S. T.; PERSINOTI, G. F.; SILVA, N. V.; VASCONCELOS, A. A.; PEREIRA, G. A. G.; CARAZZOLLE, M. F. Bioinformatics applied to biotechnology: A review towards bioenergy research. BIOMASS & BIOENERGY, v. 123, p. 195-224, APR 2019. Web of Science Citations: 1.
NAGAMATSU, SHEILA TIEMI; TEIXEIRA, GLEIDSON SILVA; BEZERRA DE MELLO, FELLIPE DA SILVEIRA; GALVAO TIZEI, PEDRO AUGUSTO; GRICHOSWSKI NAKAGAWA, BRUNA TATSUE; DE CARVALHO, LUCAS MIGUEL; GUIMARAES PEREIRA, GONCALO AMARANTE; CARAZZOLLE, MARCELO FALSARELLA. Genome Assembly of a Highly Aldehyde-Resistant Saccharomyces cerevisiae SA1-Derived Industrial Strain. MICROBIOLOGY RESOURCE ANNOUNCEMENTS, v. 8, n. 13 MAR 2019. Web of Science Citations: 1.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.
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