Performance evaluation of two different surface texturing in the peri-implant osteogenesis in spontaneously hypertensive rats (SHR) and treated with losartan

• Grant number: 17/16912-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: November 01, 2017
• End date: June 30, 2021
• Field of knowledge: Health Sciences - Dentistry - Oral and Maxillofacial Surgery
• Principal Investigator: Roberta Okamoto
• Grantee: Jaqueline Silva dos Santos
• Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil

Abstract

The aim of this study will be to investigate the bone metabolism dynamics of bone / implant interface in SHR rats that will have the implant placement and analyze what the influences that losartan treatment may lead to peri-implant bone. Forty-eight male rats will be used, 24 (SHR) and normotensive 24 (Wistar). Surgery will be performed to install an implant textured surface, or Neoporos and Acqua in each animal tibia, that is, two implants of surfaces per animal. The analysis will be divided according into groups and subgroups: Analysis I- the tibia (n = 6) will be used for MicroCT analysis; Analysis II- the tibia (n = 6), shall be submitted to decalcification process for paraffin embedding, and the cut with semi-serial sections will be mounted and will be used for immunohistochemical analysis with antibodies VEGF, OPG, RANKL and OC; tibia will be used for histological analysis, where the quality of the bone tissue maturation, inflammation and cell morphology will be assessed. All quantitative results will be statistically analyzed adopting a 5% significance level. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GABRIEL MULINARI-SANTOS; JAQUELINE SILVA DOS SANTOS; LETÍCIA PITOL PALIN; ANA CLÁUDIA ERVOLINO DA SILVA; CRISTINA ANTONIALI; LEONARDO PEREZ FAVERANI; ROBERTA OKAMOTO. Losartan improves alveolar bone dynamics in normotensive rats but not in hypertensive rats. Journal of Applied Oral Science, v. 27, 2019-10-07. (17/23082-3, 17/16912-0, 16/03245-2)

MULINARI-SANTOS, GABRIEL; DOS SANTOS, JAQUELINE SILVA; KITAGAWA, IGOR LEBEDENCO; BATISTA, FABIO ROBERTO DE SOUZA; BOTACIN, PAULO ROBERTO; ANTONIALI, CRISTINA; LISBOA-FILHO, PAULO NORONHA; OKAMOTO, ROBERTA. Estrogen Deficiency Impairs Osseointegration in Hypertensive Rats Even Treated with Alendronate Coated on the Implant Surface. JOURNAL OF FUNCTIONAL BIOMATERIALS, v. 14, n. 9, p. 13-pg., 2023-09-01. (17/16912-0, 17/23082-3)