Evaluation of metabolic parameters of experimental animal models in response to dietary interesterified fat: underlaying molecular mechanisms

• Grant number: 16/24768-3
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: December 01, 2018
• End date: April 30, 2023
• Field of knowledge: Health Sciences - Nutrition - Nutrition Biochemistry
• Principal Investigator: Marciane Milanski Ferreira
• Grantee: Josiane Érica Miyamoto
• Host Institution: Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil
• Associated research grant: 13/07607-8 - OCRC - Obesity and Comorbidities Research Center, AP.CEPID
• Associated scholarship(s): 20/16040-5 - Metabolic effects of interesterified fat and its metabolites on glucose and lipid homeostasis, BE.EP.DR

Abstract

The actual dietary pattern is characterized by high consumption of processed food which contains high content of lipids, including trans fatty acids. The excess of these type of fatty acids in the diet can rise LDL-c levels and is related to coronary diseases and diabetes. Nowadays, interesterified fats have been used as an alternative to substitute the trans fat once this was proved to be able to modulate the lipid profile and then predisposing to cardiovascular disease. The chemical process of interestrification of oils and fat rearranges fatty acids in triglycerides and promote changes in its structure, this process allows the food industry to produce plastic fats. Lipids are known to be involved in many process of regulation of homeostasis and in several cellular activities and there is well established that the excess of this dietary component can lead to development of obese phenotype and it consequences, but the role of interesterified fat in metabolism is not elucidated. Therefore, the aim of this work is to evaluate the dietary sources of lipids and their role on metabolic parameters and underlying molecular mechanisms that are involved in response of dietary interesterified fat obtained from chemical randomization in animal models. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MIYAMOTO, JOSIANE ERICA; REGINATO, ANDRESSA; PORTOVEDO, MARIANA; DOS SANTOS, RAISA MAGNO; STAHL, MARCELLA APARECIDA; LE STUNFF, HERVE; LATORRACA, MARCIA QUEIROZ; DE BARROS REIS, MARISE AUXILIADORA; ARANTES, VANESSA CRISTINA; DONEDA, DIEGO LUIZ; et al. Interesterified palm oil impairs glucose homeostasis and induces deleterious effects in liver of Swiss mice. METABOLISM-CLINICAL AND EXPERIMENTAL, v. 112, NOV 2020. (16/24768-3)

LORIZOLA, ISABELA MICHELETTI; MIYAMOTO, JOSIANE ERICA; FIGUEIREDO VIEIRA, ANA LUIZA; SUMERE, BEATRIZ ROCCHETTI; NEVES BEZERRA, ROSANGELA MARIA; TORSONI, MARCIO ALBERTO; TORSONI, ADRIANA SOUZA; ROSTAGNO, MAURICIO ARIEL; MILANSKI, MARCIANE; CAPITANI, CAROLINE DARIO. Beet (Beta vulgaris L.) stalk and leaf supplementation changes the glucose homeostasis and inflammatory markers in the liver of mice exposed to a high-fat diet. FOOD CHEMISTRY: MOLECULAR SCIENCES, v. 2, p. 10-pg., 2021-07-30. (13/04304-4, 13/18498-5, 16/24768-3, 15/15035-0)

MIYAMOTO, J. E.; SANTOS, R. M. A.; SIQUEIRA, B. P.; REGINATO, A.; GUITTON, J.; MENTA, P. L. R.; RAMALHEIRA, T. G.; TORSONI, A. S.; IGNACIO-SOUZA, L. M.; TORSONI, M. A.; et al. Effect of interesterified fat and its metabolites on inflammation and insulin resistance in hypothalamus. Diabetologia, v. 65, n. SUPPL 1, p. 2-pg., 2022-09-01. (16/24768-3, 17/15925-0, 20/16040-5, 19/26538-3)