Advanced search
Start date
Betweenand

Poly(vinyl alcohol) effect on the micellar packing and photochemical nitric oxide release from S-nitrosoglutathione in Pluronic F-127 solutions

Grant number: 19/00913-2
Support type:Scholarships abroad - Research Internship - Scientific Initiation
Effective date (Start): March 15, 2019
Effective date (End): July 14, 2019
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
Principal researcher:Marcelo Ganzarolli de Oliveira
Grantee:Giovanna Jardim Vieira Pereira dos Santos
Supervisor abroad: Cecile Ayako Dreiss
Home Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Research place: King's College London, England  
Associated to the scholarship:17/04615-0 - Nitric oxide releasing collagen membranes for bone regeneration, BP.IC

Abstract

The main aim of this project is to characterize the influence of poly(vinyl alcohol) (PVA) on the phase behavior of Pluronic F127 hydrogels by Small Angle Neutron Scattering (SANS) and Differential Scanning Calorimetry (DSC). SANS experiments will be performed at the ISIS facility, Rutherford Appleton Laboratory, UK. DSC thermograms will be obtained in a Q10 calorimeter (TA Instruments) at the Institute of Pharmaceutical Science, King's College, London UK. The microphases of these hydrogels will be further correlated with the kinetics of photochemical nitric oxide (NO) release from S-nitrosoglutathione (GSNO) incorporated into these hydrogels in Brazil. The potential biomedical applications of the F127/PVA/GSNO for the topical delivery of NO will be evaluated. (AU)