Poly(vinyl alcohol) effect on the micellar packing and photochemical nitric oxide release from S-nitrosoglutathione in Pluronic F-127 solutions

• Grant number: 19/00913-2
• Support Opportunities: Scholarships abroad - Research Internship - Scientific Initiation
• Effective date (Start): March 15, 2019
• Effective date (End): July 14, 2019
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
• Principal Investigator: Marcelo Ganzarolli de Oliveira
• Grantee: Giovanna Jardim Vieira Pereira dos Santos
• Supervisor: Cecile Ayako Dreiss
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Research place: King's College London, England
• Associated to the scholarship: 17/04615-0 - Nitric oxide releasing collagen membranes for bone regeneration, BP.IC

Abstract

The main aim of this project is to characterize the influence of poly(vinyl alcohol) (PVA) on the phase behavior of Pluronic F127 hydrogels by Small Angle Neutron Scattering (SANS) and Differential Scanning Calorimetry (DSC). SANS experiments will be performed at the ISIS facility, Rutherford Appleton Laboratory, UK. DSC thermograms will be obtained in a Q10 calorimeter (TA Instruments) at the Institute of Pharmaceutical Science, King's College, London UK. The microphases of these hydrogels will be further correlated with the kinetics of photochemical nitric oxide (NO) release from S-nitrosoglutathione (GSNO) incorporated into these hydrogels in Brazil. The potential biomedical applications of the F127/PVA/GSNO for the topical delivery of NO will be evaluated. (AU)