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Raman microscopy and spectroscopy: non-invasive techniques to evaluate skin penetration and free radical formation of cosmetic formulations

Grant number: 19/12452-0
Support Opportunities:Scholarships abroad - Research Internship - Doctorate (Direct)
Effective date (Start): October 02, 2019
Effective date (End): October 01, 2020
Field of knowledge:Health Sciences - Pharmacy
Principal Investigator:Patrícia Maria Berardo Gonçalves Maia Campos
Grantee:Victor Hugo Pacagnelli Infante
Supervisor: Jurgen Lademann
Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Research place: Charité - Universitätsmedizin Berlin, Germany  
Associated to the scholarship:16/13705-0 - Research and development of cosmetic products for the male audience with essential oils: characterization of skin, clinical efficacy, consumer profile and influence of advertising, BP.DD


As Brazilian men, in general, do not have the habit of use of skin care products and/or sunscreens frequently, and their skin health can be affected. The development of multifunctional formulations with sun protection, antipollution, antiacne and antioxidant properties could be a strategy to improve men's skin, since these protections are important to avoid the extrinsic ageing process. Thus, it is important to understand the penetration profile of cosmetic products since can present different pathways, such as intracellular, intercellular and/or follicular. Confocal Raman microscopy (CRM) is employed to study the skin physiology,drug permeation and skin disease monitoring. The in vivo resonance Raman spectroscopy can monitor the changes of cutaneous betacarotene and lycopene non invasively. The method is quick, painless and can be repeated easily. This way, free essential oils and/or nanoemulsions of these active substances can be good alternatives to prevent the free radical formation and alternative acne treatment. In this context, the objectives of this study are to utilize these noninvasive techniques to analyze the penetration of active substances (essential oils, nanoemulsion and UV filters) in the skin and the capacity to reduce free radical formation in cosmetic formulation. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
INFANTE, V. H. P.; MAIA CAMPOS, P. M. B. G.; CALIXTO, L. S.; DARVIN, M. E.; KROEGER, M.; SCHANZER, S.; LOHAN, S. B.; LADEMANN, J.; MEINKE, M. C.. Influence of physical-mechanical properties on SPF in sunscreen formulations on ex vivo and in vivo skin. International Journal of Pharmaceutics, v. 598, . (19/12452-0, 16/13705-0)
INFANTE, VICTOR H. P.; MAIA CAMPOS, PATRICIA M. B. G.; GASPAR, LORENA RIGO; DARVIN, MAXIM E.; SCHLEUSENER, JOHANNES; RANGEL, KAREN C.; MEINKE, MARTINA C.; LADEMANN, JUERGEN. afety and efficacy of combined essential oils for the skin barrier properties: In vitro, ex vivo and clinical studie. International Journal of Cosmetic Science, v. 44, n. 1, p. 118-130, . (19/12452-0, 16/13705-0)
INFANTE, VICTOR HUGO PACAGNELLI; LOHAN, SILKE B.; SCHANZER, SABINE; CAMPOS, PATRICIA MARIA BERARDO GONSALVES MAIA; LADEMANN, JUERGEN; MEINKE, MARTINA C.. Eco-friendly sunscreen formulation based on starches and PEG-75 lanolin increases the antioxidant capacity and the light scattering activity in the visible light. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, v. 222, . (16/13705-0, 19/12452-0)
INFANTE, VICTOR HUGO; MAIA CAMPOS, PATRICIA MARIA; DARVIN, MAXIM; LOHAN, SILKE; SCHLEUSENER, JOHANNES; SCHANZER, SABINE; LADEMANN, JUERGEN; MEINKE, MARTINA. Cosmetic Formulations with Melaleuca alternifolia Essential Oil for the Improvement of Photoaged Skin: A Double-Blind, Randomized, Placebo-Controlled Clinical Study. Photochemistry and Photobiology, v. N/A, p. 8-pg., . (19/12452-0, 16/13705-0)

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