Determination of chemical composition, bioaccessibility and evaluation of antidiabetic and prebiotic activities from Xique-Xique (Pilosocereus gounellei) and Mandacaru (Cereus jamacaru) fruits

• Grant number: 20/15163-6
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: September 01, 2021
• End date: August 31, 2025
• Field of knowledge: Agronomical Sciences - Food Science and Technology - Food Science
• Principal Investigator: Alexandra Christine Helena Frankland Sawaya
• Grantee: Fábio Fernandes de Araújo
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated scholarship(s): 22/04530-3 - Antidiabetic potential of xique-xique (Pilosocereus gounellei) and mandacaru (Cereus jamacaru) fruits after colonic fermentation, BE.EP.PD

Abstract

Type 2 Diabetes is a chronic noncommunicable disease that has raised major concerns in global health. Currently, this disease is controlled through the use of conventional drugs and dietary restrictions. However, the search for new agents capable of helping to reduce glycemia as well as damage to the body resulting from Diabetes is increasing. Phenolic compounds are secondary metabolites of the plants, commonly found in fruits and vegetables that are gaining more and more prominence in the scientific community due to their functional potential in the control of several diseases, including Type 2 Diabetes. Native species from the Caatinga region such as Xique-Xique and Mandacaru are of great importance for the subsistence of the regional population and can be considered good sources of nutrients and bioactive compounds, such as phenolics. However, little information is available in the literature about their potential functional and biological properties. Thus, the objective of this study will be to evaluate the chemical composition, bioaccessibility and in vitro anti-diabetic and prebiotic activities of Xique-Xique and Mandacaru fruits. The results of this study will provide important information about the nutritional and functional potential of these fruits, in order to encourage their production, commercial exploitation and application in the development of new products and as agents with beneficial properties for health. (AU)

Scientific publications

(11)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PAULINO, BRUNO N.; SILVA, GLORIA N. S.; ARAUJO, FABIO F.; NERI-NUMA, IRAMAIA A.; PASTORE, GLAUCIA M.; BICAS, JULIANO L.; MOLINA, GUSTAVO. Beyond natural aromas: The bioactive and technological potential of monoterpenes. TRENDS IN FOOD SCIENCE & TECHNOLOGY, v. 128, p. 14-pg., 2022-08-26. (16/21619-7, 20/06814-3, 20/15163-6)

DE SOUZA, FLORISVALDO GAMA; DE ARAUJO, FABIO FERNANDES; ORLANDO, EDUARDO ADILSON; RODRIGUES, FERNANDO MORAIS; HIDALGO CHAVEZ, DAVY WILLIAM; LIMA PALLONE, JULIANA AZEVEDO; NERI-NUMA, IRAMAIA ANGELICA; HELENA FRANKLAND SAWAYA, ALEXANDRA CHRISTINE; PASTORE, GLAUCIA MARIA. Characterization of Buritirana (Mauritiella armata) Fruits from the Brazilian Cerrado: Biometric and Physicochemical Attributes, Chemical Composition and Antioxidant and Antibacterial Potential. FOODS, v. 11, n. 6, p. 16-pg., 2022-03-01. (15/50333-1, 20/15163-6)

BORSOI, FELIPE TECCHIO; NERI-NUMA, IRAMAIA ANGELICA; DE OLIVEIRA, WILLIARA QUEIROZ; DE ARAUJO, FABIO FERNANDES; PASTORE, GLAUCIA MARIA. Dietary polyphenols and their relationship to the modulation of non-communicable chronic diseases and epigenetic mechanisms: A mini-review. FOOD CHEMISTRY: MOLECULAR SCIENCES, v. 6, p. 14-pg., 2022-12-20. (20/15163-6, 20/08761-4)

FARIAS, DAVID DE PAULO; DE ARAUJO, FABIO FERNANDES; NERI-NUMA, IRAMAIA ANGELICA; DIAS-AUDIBERT, FLAVIA LUISA; DELAFIORI, JEANY; CATHARINO, RODRIGO RAMOS; PASTORE, GLAUCIA MARIA. Effect of in vitro digestion on the bioaccessibility and bioactivity of phenolic compounds in fractions of Eugenia pyriformis fruit. Food Research International, v. 150, n. A, DEC 2021. (20/00225-6, 19/05718-3, 20/15163-6, 15/50333-1)

DE OLIVEIRA, WILLIARA QUEIROZ; NUMA, IRAMAIA ANGELICA NERI; ALVIM, IZABELA D.; AZEREDO, HENRIETTE M. C.; SANTOS, LETICIA B.; BORSOI, FELIPE T.; DE ARAUJO, FABIO F.; SAWAYA, ALEXANDRA C. H. F.; DO NASCIMENTO, GUSTAVO C.; CLERICI, MARIA TERESA P. S.; et al. Multilayer microparticles for programmed sequential release of phenolic compounds from Eugenia stipitata: Stability and bioavailability. Food Chemistry, v. 443, p. 12-pg., 2024-01-31. (20/08761-4, 20/15163-6, 22/04530-3)

FARIAS, DAVID DE PAULO; DE ARAUJO, FABIO FERNANDES; SAWAYA, ALEXANDRA C. H. F.; NERI-NUMA, IRAMAIA ANGELICA; PASTORE, GLAUCIA MARIA. Impacts of in vitro gastrointestinal digestion on phenolic compounds bioaccessibility and biological activities of uvaia (Eugenia pyriformis Cambess) fractions. Process Biochemistry, v. 153, p. 11-pg., 2025-06-01. (20/00225-6, 20/15163-6, 22/05242-1, 15/50333-1, 22/04530-3)

FARIAS, DAVID DE PAULO; DE ARAUJO, FABIO FERNANDES; HUYAN, ZONGYAO; VILLASANTE, JULIANA; RANPATABENDI, THISUN; FOGLIANO, VINCENZO; PASTORE, GLAUCIA MARIA. Effect of colonic fermentation of uvaia (Eugenia pyriformis Cambess) fractions on phenolic compounds and gut microbiota composition: An vitro study using the Simulator of the Human Intestinal Microbial Ecosystem (SHIME®). Food Chemistry, v. 488, p. 11-pg., 2025-10-01. (22/04530-3, 22/05242-1, 20/00225-6, 15/50333-1, 20/15163-6)

FARIAS, DAVID DE PAULO; ARAUJO, FABIO FERNANDES DE; VILLASANTE, JULIANA; FOGLIANO, VINCENZO; PASTORE, GLAUCIA MARIA. In vitro gastrointestinal digestion and gut microbiota fermentation of phenolic compounds from uvaia. Food Chemistry, v. 477, p. 10-pg., 2025-03-04. (22/04530-3, 22/05242-1, 15/50333-1, 20/15163-6, 20/00225-6)

DE ARAUJO, FABIO FERNANDES; FARIAS, DAVID DE PAULO; NERI-NUMA, IRAMAIA ANGELICA; PASTORE, GLAUCIA MARIA; SAWAYA, ALEXANDRA CHRISTINE HELENA FRANKLAND. Bioaccessibility and Antidiabetic Potential of xique-xique and mandacaru Fruits in a Simulated Gastrointestinal Tract Model. FOODS, v. 13, n. 20, p. 12-pg., 2024-10-01. (20/00225-6, 20/15163-6, 22/04530-3)

DE ARAUJO, FABIO FERNANDES; FARIAS, DAVID DE PAULO; RANPATABENDI, THISUN; NERI-NUMA, IRAMAIA ANGELICA; PASTORE, GLAUCIA MARIA; SAWAYA, ALEXANDRA CHRISTINE HELENA FRANKLAND. Comparative assessment of nutritional composition, phenolic compounds, antioxidative and antidiabetic properties of pilosocereus gounellei and Cereus Jamacaru: two unexplored cactus fruits from the Brazilian semi-arid. CYTA-JOURNAL OF FOOD, v. 22, n. 1, p. 8-pg., 2024-12-31. (20/00225-6, 20/15163-6, 15/50333-1)

BORGHI, ALEXANDRE AUGUSTO; MINATEL, ELAINE; MIZOBUTI, DANIELA SAYURI; DE LOURENCO, CAROLINE CARAMANO; DE ARAUJO, FABIO FERNANDES; PASTORE, GLAUCIA MARIA; HEWITSON, PETER; IGNATOVA, SVETLANA; SAWAYA, ALEXANDRA C. H. F.. Antioxidant and Anti-inflammatory Activity of Mikania glomerata and Mikania laevigata Extracts. PHARMACOGNOSY RESEARCH, v. 15, n. 1, p. 10-pg., 2023-01-01. (15/50333-1, 20/09733-4, 20/15163-6)