Synthesis and Characterization of Cationic Derivatives of Chitosan and their interaction with Vesicles of DPPC.

• Grant number: 09/11707-2
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: October 01, 2009
• End date: December 31, 2010
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
• Principal Investigator: Marcio José Tiera
• Grantee: Fábio Domingues Nasário
• Host Institution: Instituto de Biociências, Letras e Ciências Exatas (IBILCE). Universidade Estadual Paulista (UNESP). Campus de São José do Rio Preto. São José do Rio Preto , SP, Brazil

Abstract

The main purpose of this project is to study the interaction between cationic derivatives of chitosan and DPPC. The synthesis will be carried out employing low molecular weight chitosans to obtain derivatives containing different hydrophilic and hydrophobic contents. The self association study of these derivatives in aqueous solution will be carried out in the second step as well as the study of interaction between the derivatives and of DPPC/ PG membrane models.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MARTINS, DANUBIA BATISTA; NASARIO, FABIO DOMINGUES; SILVA-GONCALVES, LAIZ COSTA; DE OLIVEIRA TIERA, VERA APARECIDA; ARCISIO-MIRANDA, MANOEL; TIERA, MARCIO JOSE; DOS SANTOS CABRERA, MARCIA PEREZ. Chitosan derivatives targeting lipid bilayers: Synthesis, biological activity and interaction with model membranes. Carbohydrate Polymers, v. 181, p. 1213-1223, FEB 1 2018. (12/02065-0, 09/11707-2, 10/11823-0, 12/24259-0, 12/03619-9, 14/08372-7)