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| Author(s): |
Leonardo Mendes de Souza Mesquita
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | São Vicente. 2017-05-17. |
| Institution: | Universidade Estadual Paulista (Unesp). Instituto de Biociências. São Vicente |
| Defense date: | 2017-01-13 |
| Advisor: | Wagner Vilegas |
| Abstract | |
Plant species containing bioactive compounds are continuously being investigated, in order to search for alternative therapeutic treatments. These studies can reveal substances that can be explored in order to produce new drugs. Investigation of plants are of great importance, because of the large amounts of secondary metabolites that can be found. They have increasingly attracted the attention of the society, proving to be an alternative source to the high costs of allopathic medicines. However, multidisciplinary studies are necessary to ensure that plants are used with effectively and safety. The National Sanitary Surveillance Agency and the Ministry of Health have approved 71 medicinal plants to be used against diabetes, ulcers, inflammation and other chronic diseases. However, this list is still limited because several species are not available year-round and/or in the various regions of Brazil. In contrast, Rhizophora mangle (Rhizophoraceae, popularly known as red mangrove) is a Brazilian species that occurs from Pará to Santa Catarina. It is commonly used by traditional coastal populations, mainly for the treatment of diabetes, hemorrhoids, analgesia and stomach pains. Recently, our research group verified that the acetone extract of R. mangle barks has antioxidant and antiulcerogenic activities and it is also effective in the treatment of the experimental colitis. However, only a preliminary evaluation of the chemical composition of the barks was previously carried out. Thus, this work deals with the chemical study of R. mangle, emphasizing the study of barks. We developed analytical strategies based on Electrospray- Ion trap mass spectrometry as well as MALTI-TOF techniques that allowed the qualitative standardization of the active extract. As a result, we could identify a sequence of condensed tannins with polymerization degree from 2 to 12. Besides, we tested this extract to treat obesity and as anti-inflammatory, with promising results.These results allowed us to better understant the farmacological activities observed. (AU) | |
| FAPESP's process: | 14/23951-3 - Standardized phytotherapics for the treatment of chronicle diseases: Rhizophora mangle |
| Grantee: | Leonardo Mendes de Souza Mesquita |
| Support Opportunities: | Scholarships in Brazil - Master |